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La Roquette-sur-Siagne, France

Lefranc-Millot C.,Nutrition Direction | Guerin-Deremaux L.,Nutrition Direction | Wils D.,Nutrition Direction | Neut C.,College de France | And 2 more authors.
Journal of International Medical Research | Year: 2012

Objectives: The prebiotic potential of NUTRIOSE® - a sugar-free, digestionresistant dextrin - was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. Methods: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis. Results: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased b-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose. Conclusion: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort. © 2012 Field House Publishing LLP. Source

Lefranc-Millot C.,Nutrition Direction | Chanson-Rolle A.,VAB nutrition | MacIoce V.,Nutrition Direction | Azdis-Braesco V.,VAB nutrition
CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources | Year: 2011

The beneficial role of dietary fibre in general health is well recognized, and recommended intakes are usually 21-38 g/day, depending on age, gender and country. However, actual dietary fibre intakes are below these recommendations in most Western countries. In order to improve the dietary fibre intakes of the population, national dietary guidelines encourage the consumption of fibre-rich foods, including naturally rich foods and fortified foods. Non-viscous soluble fibres have been widely used to fortify foods, and several physiological and health effects have been proposed to be associated with their consumption. The current article aims at reviewing the available scientific evidence to support these effects, with specific references to polydextrose, resistant dextrins and resistant maltodextrins, and focusing on benefits related to intestinal well-being, prebiotic effects, weight management and satiety. Recent findings obtained in humans and animals are highlighted, and when permitted, the level of evidence available for each type of fibre is compared. Although the degree of evidence, and thus conclusion of the scientific evaluation, varies according to the considered benefit and fibre type, the review of available data suggests that the soluble fibres highlighted in this paper may exert several benefits in relation to intestinal wellbeing, control of satiety and weight management, and to a lower extent, prebiotic properties. Nevertheless, more data from good-quality human trials are clearly needed to draw conclusions on the specific beneficial impacts associated with the consumption of these types of soluble fibres. Source

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