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Minooee S.,Reproductive Endocrinology Research Center | Ramezani T.F.,Reproductive Endocrinology Research Center | Mirmiran P.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in reproductive aged women. The association of early-life factors such as fetal adipose tissue and birth weight with adulthood outcomes like obesity, body fat mass (BFM) and body lean mass (BLM) is not clearly understood. We aimed to compare the association between birth weight and body composition in women with PCOS and normal controls. Materials and Methods: For this study we enrolled a total of 70 reproductive aged women with PCOS diagnosis, referring to the Reproductive Endocrinology Research Center and the same number of healthy women without polycystic ovaries by ultrasonography or hirsutism and/or anyovulatory other dysfunction were enrolled. Their birth weights were documented and their body composition was assessed, using standard measuring devices. Results: Cases were younger than the controls (29.7±4.9 versus 30.8±5.9 years) and had the same BMI (24.6±2.4 versus 24.8±4.5 kg/m2). Our study demonstrated that BFM and BLM are increased in adult PCOS women born underweight, compared to their normal counterparts (16± 4.7 versus 12.2± 4.1, P= 0.06 and 46.4±5.8 versus 41.1±5.8, P=0.07). Conclusion: The impact of fetal adipose tissue and birth weight on the occurrence adulthood obesity, BFM and BLM vary between women with and without PCOS. © 2015, Endocrine Research Center. All rights reserved. Source


Hosseini-Esfahani F.,Nutrition and Endocrine Research Center | Daneshpour M.,Research Institute for Endocrine science | Hedayati M.,Research Institute for Endocrine science | Mirmiran P.,National Nutrition and Food Technology Research Institute | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: The aim of this study was to evaluate the interaction between dietary fatty acids and the genetic variant of APOC3 rs5128 3238C>G in relation to metabolic syndrome (MetS) components in adults. Materials and Methods: In this matched nested case-control study, 755 MetS subjects and 755 controls were selected from among participants of the Tehran Lipid and Glucose Study. Dietary intake was determined using a valid and reliable food frequency questionnaire. APOC3 was genotyped by the conventional polymerase chain reaction and restriction fragment length polymorphism. Results: Mean ages of men and women were not different in cases and controls. The frequency of C allele was 81%, which did not differ in cases and controls or in men and women. Compared to CC genotype, low HDL-C risk was increased in women with the CG+GG genotypes and with cholesterol intakes 8208 mg/day (OR: 1.93). In men with the CG+GG genotypes and saturated fatty acid (SFA) intakes 89.8% of energy, OR of high diastolic blood pressure (BP) was 2.15(1-1.46), compared to individuals with SFA intake <9.8% of energy and CC genotype. Compared to the CC genotype, the risk of high diastolic BP was higher in men carrying the G allele and consuming mono-unsaturated fatty acid (MUFA) intakes 89.4% of energy. Conclusions: Results demonstrate a nutri-genetic interaction between rs5128 and fat intakes in relation to components of MetS; individuals with G allele carriers and higher intakes of cholesterol, MUFA or SFA had higher risk of low HDL-C and hypertension than the CC genotype. © 2015 Iranian Journal of Endocrinology and Metabolism. All rights received. Source


Mottaghi A.,Obesity Research Center | Mirmiran P.,Shahid Beheshti University of Medical Sciences | Delshad H.,Obesity Research Center | Azizi F.,Nutrition and Endocrine Research Center
Journal of the American College of Nutrition | Year: 2015

Background: The aim of this community-based study is to ascertain the effect of different obesity phenotypes on the incidence of chronic kidney disease in Iranian adults. Study Design: A prospective cohort study, the Tehran Lipid Glucose Study (TLGS). Setting and Participants: Adults aged ≥ 20 years with a mean age of 40.38 years (54.8% female) who were free from chronic kidney disease (CKD) at baseline (phase 1) and were followed up at 3 time stages (phases 2, 3, and 4) for a mean duration of 9.4 years to assess the risk for CKD. Predictor: Obesity phenotypes. Outcome: Incidence of chronic kidney disease. Measurements: Glomerular filtration rate (GFR) was estimated from the simplified equation developed using data from the Modification of Diet in Renal Disease (MDRD) Study. Results: CKD events occurred in 1162 participants. The prevalence of the 2 known obesity phenotypes (metabolically obese normal weight [MONW] and metabolically healthy but obese [MHO]) in the overall population was 3.5% and 8.8%, respectively. According to Kaplan-Meier curves, rates of freedom from CKD in the MHO and MONW obesity phenotypes were 75.3% and 60.6%, respectively (p < 0.0001). Age- and sex-adjusted (model 1) hazard ratios for participants with MHO or MONW obesity phenotype were 1.14 (95% confidence interval [CI], 0.91–1.43) and 1.43 (95% CI, 1.09–1.88), respectively. After further adjustment for confounder variables (model 2), multivariate-adjusted hazard ratios for CKD for participants with MHO or MONW obesity phenotypes were 1.23 (95% CI, 0.93–1.62) and 1.43 (95% CI, 1.08–1.90), respectively. Conclusion: Adults with the MONW obesity phenotype compared to those with MHO obesity phenotype have a higher risk for incidence of CKD. The results indicate that having a normal weight is not the only factor to protect against incidence of CKD. 2015 © American College of Nutrition Source


Ghasemi A.,Research Institute for Endocrine science | Zahediasl S.,Research Institute for Endocrine science | Hosseini-Esfahani F.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Annals of Human Biology | Year: 2014

Background: Zinc, a co-factor of antioxidant enzymes, may be involved in the pathophysiology of metabolic syndrome (MetS). Aim: To determine the association between serum zinc concentration and MetS in a population-based study. Subjects and methods: In the Tehran Lipid and Glucose Study, serum zinc concentration was measured by flame atomic absorption spectrometry in 2626 adult participants. After removal of outliers, usable data was available for 2401 participants. Dietary zinc was assessed by a validated semi-quantitative food frequency questionnaire. Results: Compared to those without the MetS, serum zinc concentration was significantly higher in men with syndrome (17.1±4.9 vs 16.5±4.6μmol/L, p=0.035); however, values were comparable in females (16.1±4.8 vs 15.8±4.4, p=0.460). Men in tertile 3 of serum zinc had significantly higher chances of having MetS, even after multivariate adjustment (OR=1.48, 95% confidence interval (CI)=1.07-2.06, p=0.020). Women in tertile 2 of serum zinc had significantly lower chances of having MetS, which remained significant after multivariate adjustment (OR=0.68, 95% CI=0.47-0.99, p=0.046). Conclusion: This study observed a gender difference between serum zinc and MetS, with higher levels being positively associated with MetS in men and having a protective effect in women. Further studies are needed to elucidate the role of zinc status in the development of MetS. © 2014 Informa UK Ltd. All rights reserved. Source


Hadi S.,National Nutrition and Food Technology Research Institute | Mirmiran P.,Nutrition and Endocrine Research Center | Hosseinpour-Niazi S.,Nutrition and Endocrine Research Center | Hedayati M.,Cellular and Molecular Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Improvement of lipid abnormalities are important in the prevention of diabetes complications. The study aimed to determine the effect of nigella sativa oil extract oil on blood lipid abnormalities in patients with type 2 diabetes. Materials and Methods: In this double blind randomized clinical trial, 43 men and women with type 2 diabetes who were randomized to the intervention (n=23) and placebo (n=20) groups were studied and compared. The intervention group received 2 capsules daily, (500 mg extract of Black Seed Oil) while the control group took 2 capsules (500 mg, placebo daily) for 8 weeks, respectively. Lipid profiles were measured at the beginning and end of the intervention. Result: Mean age and body mass index of participants was 53.7±6.0 y and 28.6±5.4 kg/m2, respectively. At the end of the eighth week, the concentrations of serum triglycerides, LDL cholesterol, total cholesterol and LDL to HDL cholesterol of the intervention group were compared to the placebo group, and a significant reduction (P<0.05) was found. However concentrations of HDL cholesterol and total cholesterol to HDL cholesterol ratio, at the of the end eighth week in the intervention group and the control group showed no significant difference. Conclusion: Black Seed Oil extract improves lipid profiles in type 2 diabetic patients. © 2015, Endocrine Research Center. All rights reserved. Source

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