Nutrition and Endocrine Research Center

Iran

Nutrition and Endocrine Research Center

Iran
SEARCH FILTERS
Time filter
Source Type

Hosseini-Esfahani F.,Nutrition and Endocrine Research Center | Daneshpour M.,Research Institute for Endocrine science | Hedayati M.,Research Institute for Endocrine science | Mirmiran P.,National Nutrition and Food Technology Research Institute | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: The aim of this study was to evaluate the interaction between dietary fatty acids and the genetic variant of APOC3 rs5128 3238C>G in relation to metabolic syndrome (MetS) components in adults. Materials and Methods: In this matched nested case-control study, 755 MetS subjects and 755 controls were selected from among participants of the Tehran Lipid and Glucose Study. Dietary intake was determined using a valid and reliable food frequency questionnaire. APOC3 was genotyped by the conventional polymerase chain reaction and restriction fragment length polymorphism. Results: Mean ages of men and women were not different in cases and controls. The frequency of C allele was 81%, which did not differ in cases and controls or in men and women. Compared to CC genotype, low HDL-C risk was increased in women with the CG+GG genotypes and with cholesterol intakes 8208 mg/day (OR: 1.93). In men with the CG+GG genotypes and saturated fatty acid (SFA) intakes 89.8% of energy, OR of high diastolic blood pressure (BP) was 2.15(1-1.46), compared to individuals with SFA intake <9.8% of energy and CC genotype. Compared to the CC genotype, the risk of high diastolic BP was higher in men carrying the G allele and consuming mono-unsaturated fatty acid (MUFA) intakes 89.4% of energy. Conclusions: Results demonstrate a nutri-genetic interaction between rs5128 and fat intakes in relation to components of MetS; individuals with G allele carriers and higher intakes of cholesterol, MUFA or SFA had higher risk of low HDL-C and hypertension than the CC genotype. © 2015 Iranian Journal of Endocrinology and Metabolism. All rights received.


Mohseni-Takalloo S.,Shahid Beheshti University of Medical Sciences | Mirmiran P.,National Nutrition and Food Technology Research Institute | Mirmiran P.,Nutrition and Endocrine Research Center | Hosseini-Esfahani F.,Nutrition and Endocrine Research Center | And 2 more authors.
Iranian Journal of Endocrinology and Metabolism | Year: 2013

Introduction: The "Dietary Guidelines for Americans Adherence Index (DGAI)" was developed based on the adherence to the dietary recommendations of the Dietary Guidelines for Americans 2005 (DGA-2005) to assess the contribution of dietary patterns to chronic diseases. The objective of this study was to evaluate the association of dietary patterns as measured by the modified DGAI with the prevalence of metabolic syndrome (MetS) and its components in Tehranian adolescents. Materials and Methods: In this cross-sectional study, 706 adolescents aged 10 to 19 years, participated from the fourth phase of the Tehran Lipid and Glucose Study. Usual dietary intake was assessed using a valid food frequency questionnaire, and the DGAI score was calculated for all participants. MetS was defined according to de Ferranti criteria. Results: The most prevalent risk factor for MetS was high waist circumference (51.8%). After adjusting for confounding variables, those in the highest quartile category of DGAI had a 36% lower risk of low HDL-C (odds ratio=64%, 95% CI: 0.41-0.98 and P for trend=0.03) and 50% lower risk of hypertension (odds ratio=50%, 95% CI:0.25-0.99 and P for trend=0.02), compared with the lowest quartile. Increasing adherence to DGAI showed no significant difference in risk of hypertriglyceridemia, hyperglycemia, high waist circumference, MetS, mean body mass index (BMI) or physical activity scores. Conclusion: In adolescents, increasing adherence to Dietary Guidelines for Americans 2005 (DGA-2005) had only an inverse association with low HDL-C and hypertension, but had no relationship with the risk of MetS and its other components.


Minooee S.,Reproductive Endocrinology Research Center | Ramezani T.F.,Reproductive Endocrinology Research Center | Mirmiran P.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in reproductive aged women. The association of early-life factors such as fetal adipose tissue and birth weight with adulthood outcomes like obesity, body fat mass (BFM) and body lean mass (BLM) is not clearly understood. We aimed to compare the association between birth weight and body composition in women with PCOS and normal controls. Materials and Methods: For this study we enrolled a total of 70 reproductive aged women with PCOS diagnosis, referring to the Reproductive Endocrinology Research Center and the same number of healthy women without polycystic ovaries by ultrasonography or hirsutism and/or anyovulatory other dysfunction were enrolled. Their birth weights were documented and their body composition was assessed, using standard measuring devices. Results: Cases were younger than the controls (29.7±4.9 versus 30.8±5.9 years) and had the same BMI (24.6±2.4 versus 24.8±4.5 kg/m2). Our study demonstrated that BFM and BLM are increased in adult PCOS women born underweight, compared to their normal counterparts (16± 4.7 versus 12.2± 4.1, P= 0.06 and 46.4±5.8 versus 41.1±5.8, P=0.07). Conclusion: The impact of fetal adipose tissue and birth weight on the occurrence adulthood obesity, BFM and BLM vary between women with and without PCOS. © 2015, Endocrine Research Center. All rights reserved.


Hadi S.,National Nutrition and Food Technology Research Institute | Mirmiran P.,Nutrition and Endocrine Research Center | Hosseinpour-Niazi S.,Nutrition and Endocrine Research Center | Hedayati M.,Cellular and Molecular Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Improvement of lipid abnormalities are important in the prevention of diabetes complications. The study aimed to determine the effect of nigella sativa oil extract oil on blood lipid abnormalities in patients with type 2 diabetes. Materials and Methods: In this double blind randomized clinical trial, 43 men and women with type 2 diabetes who were randomized to the intervention (n=23) and placebo (n=20) groups were studied and compared. The intervention group received 2 capsules daily, (500 mg extract of Black Seed Oil) while the control group took 2 capsules (500 mg, placebo daily) for 8 weeks, respectively. Lipid profiles were measured at the beginning and end of the intervention. Result: Mean age and body mass index of participants was 53.7±6.0 y and 28.6±5.4 kg/m2, respectively. At the end of the eighth week, the concentrations of serum triglycerides, LDL cholesterol, total cholesterol and LDL to HDL cholesterol of the intervention group were compared to the placebo group, and a significant reduction (P<0.05) was found. However concentrations of HDL cholesterol and total cholesterol to HDL cholesterol ratio, at the of the end eighth week in the intervention group and the control group showed no significant difference. Conclusion: Black Seed Oil extract improves lipid profiles in type 2 diabetic patients. © 2015, Endocrine Research Center. All rights reserved.


Mottaghi A.,Obesity Research Center | Mirmiran P.,Shahid Beheshti University of Medical Sciences | Delshad H.,Obesity Research Center | Azizi F.,Nutrition and Endocrine Research Center
Journal of the American College of Nutrition | Year: 2015

Background: The aim of this community-based study is to ascertain the effect of different obesity phenotypes on the incidence of chronic kidney disease in Iranian adults. Study Design: A prospective cohort study, the Tehran Lipid Glucose Study (TLGS). Setting and Participants: Adults aged ≥ 20 years with a mean age of 40.38 years (54.8% female) who were free from chronic kidney disease (CKD) at baseline (phase 1) and were followed up at 3 time stages (phases 2, 3, and 4) for a mean duration of 9.4 years to assess the risk for CKD. Predictor: Obesity phenotypes. Outcome: Incidence of chronic kidney disease. Measurements: Glomerular filtration rate (GFR) was estimated from the simplified equation developed using data from the Modification of Diet in Renal Disease (MDRD) Study. Results: CKD events occurred in 1162 participants. The prevalence of the 2 known obesity phenotypes (metabolically obese normal weight [MONW] and metabolically healthy but obese [MHO]) in the overall population was 3.5% and 8.8%, respectively. According to Kaplan-Meier curves, rates of freedom from CKD in the MHO and MONW obesity phenotypes were 75.3% and 60.6%, respectively (p < 0.0001). Age- and sex-adjusted (model 1) hazard ratios for participants with MHO or MONW obesity phenotype were 1.14 (95% confidence interval [CI], 0.91–1.43) and 1.43 (95% CI, 1.09–1.88), respectively. After further adjustment for confounder variables (model 2), multivariate-adjusted hazard ratios for CKD for participants with MHO or MONW obesity phenotypes were 1.23 (95% CI, 0.93–1.62) and 1.43 (95% CI, 1.08–1.90), respectively. Conclusion: Adults with the MONW obesity phenotype compared to those with MHO obesity phenotype have a higher risk for incidence of CKD. The results indicate that having a normal weight is not the only factor to protect against incidence of CKD. 2015 © American College of Nutrition


Mirmiran P.,Nutrition and Endocrine Research Center | Bahadoran Z.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Endocrinology and Metabolism | Year: 2014

Background: Lipid accumulation product (LAP) is a novel biomarker of central lipid accumulation related to risk of diabetes and cardiovascular disease. In this study, we assessed the association of LAP with glucose homeostasis, lipid and lipid peroxidation, and subclinical systemic inflammation in diabetic patients. Methods: Thirty-nine male and 47 female type 2 diabetic patients were assessed for anthropometrics and biochemical measurements. LAP was calculated as [waist circumference (cm)-65]×[triglycerides (mmol/L)] in men, and [waist circumference (cm)-58]×[triglycerides (mmol/L)] in women. Associations of LAP with fasting glucose, insulin, insulin resistance index, lipid and lipoprotein levels, malondialdehyde, and high-sensitive C-reactive protein (hs-CRP) were assessed. Results: Mean age and LAP index were 53.6±9.6 and 51.9±31.2 years, respectively. After adjustments for age, sex and body mass index status, a significant positive correlation was observed between LAP index and fasting glucose (r=0.39, P < 0.001), and homeostasis model assessment of insulin resistance (r=0.31, P < 0.05). After additional adjustment for fasting glucose levels, antidiabetic and antilipidemic drugs, the LAP index was also correlated to total cholesterol (r=0.45, P < 0.001), high density lipoprotein cholesterol (HDL-C) levels (r=-0.29, P < 0.05), triglycerides to HDL-C ratio (r=0.89, P < 0.001), malondialdehyde (r=0.65, P < 0.001), and hs-CRP levels (r=0.27, P < 0.05). Conclusion: Higher central lipid accumulation in diabetic patients was related to higher insulin resistance, oxidative stress and systemic inflammation. © 2014 Korean Endocrine Society.


Ghasemi A.,Research Institute for Endocrine science | Zahediasl S.,Research Institute for Endocrine science | Hosseini-Esfahani F.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Annals of Human Biology | Year: 2014

Background: Zinc, a co-factor of antioxidant enzymes, may be involved in the pathophysiology of metabolic syndrome (MetS). Aim: To determine the association between serum zinc concentration and MetS in a population-based study. Subjects and methods: In the Tehran Lipid and Glucose Study, serum zinc concentration was measured by flame atomic absorption spectrometry in 2626 adult participants. After removal of outliers, usable data was available for 2401 participants. Dietary zinc was assessed by a validated semi-quantitative food frequency questionnaire. Results: Compared to those without the MetS, serum zinc concentration was significantly higher in men with syndrome (17.1±4.9 vs 16.5±4.6μmol/L, p=0.035); however, values were comparable in females (16.1±4.8 vs 15.8±4.4, p=0.460). Men in tertile 3 of serum zinc had significantly higher chances of having MetS, even after multivariate adjustment (OR=1.48, 95% confidence interval (CI)=1.07-2.06, p=0.020). Women in tertile 2 of serum zinc had significantly lower chances of having MetS, which remained significant after multivariate adjustment (OR=0.68, 95% CI=0.47-0.99, p=0.046). Conclusion: This study observed a gender difference between serum zinc and MetS, with higher levels being positively associated with MetS in men and having a protective effect in women. Further studies are needed to elucidate the role of zinc status in the development of MetS. © 2014 Informa UK Ltd. All rights reserved.


Mottaghi A.,Nutrition and Endocrine Research Center | Hosseini E.F.,Nutrition and Endocrine Research Center | Mirmiran P.,Shahid Beheshti University of Medical Sciences | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Identifying different food patterns may play a role in reducing the incidence of hypertension. Since most studies in this field have been cross-sectional, studies demonstrating HTN incidence are very limited. Hence we conducted this longitudinal study to determine dietary patterns and their effects on the incidence of hypertension. Materials and Methods: Dietary patterns of 1787 subjects, aged 20-60 yrs, who participated in phase 3 of Tehran Lipid and Glucose Study (TLGS) were determined using factor analysis and the association between dietary patterns and the incidence of hypertension in phase 4 of TLGS was assessed, using logistic regression. Results: Mean age across quartiles of healthy and western dietary patterns differed significantly. Individuals with lowest adherence to healthy dietary pattern and highest adherence to western dietary pattern were younger than others. Participants in the highest quartile of the healthy dietary pattern were physically more active than those in the upper quartile of western dietary pattern, who had the lowest level of physical activity. The healthy dietary pattern was negatively associated with elevated systolic blood pressure in models 2 (adjusted for age, sex, education, smoking and BMI) and 3 (adjusted for age, sex, education, smoking and BMI and physical activity) (odds ratio: 0.74 (95% CI: 0.56-0.98) and 0.74 (95% CI: 0.56-0.97) respectively, P=0.03 for both). Conclusion: Results of this study showed that adherence to the healthy dietary pattern reduced the risk of incidence of hypertension by 26%. © 2015, Endocrine Research Center. All rights reserved.

Loading Nutrition and Endocrine Research Center collaborators
Loading Nutrition and Endocrine Research Center collaborators