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Le Grazie di Ancona, Italy

Giuli C.,Geriatrics Operative Unit | Fattoretti P.,Center for Neurobiology of Aging | Mocchegiani E.,Nutrition and Aging Center | Venarucci D.,Biochemical Operative Unit | And 7 more authors.
Aging Clinical and Experimental Research

Background: Cognitive decline and dementia represent a key problem for public health as they heavily impair social functioning and independent living. The development of new strategies to support recommendations for patients and their caregivers may represent an outstanding step forward. Aims: To describe the study protocol and methods of “My Mind Project: the effect of cognitive training for elderly” (Grant No. 154/GR-2009-1584108), which investigates, by the use of a multidisciplinary approach, the effects of a comprehensive cognitive training programme on performances in aged subjects with mild–moderate Alzheimer’s disease, mild cognitive impairment and normal cognitive functioning. Methods: The study is a prospective randomized intervention for the assessment of cognitive training effects in three groups of elderly subjects with different cognitive status. A total of 321 elderly people were enrolled in Marche Region, Italy. Each subject was randomly assigned to an experimental group or to a control group. Cognitive performances and biochemical blood markers have also been analysed before cognitive training (baseline), immediately after termination (follow-up 1), after 6 months (follow-up 2) and after 2 years (follow-up 3). Discussion: The results will be useful to identify some efficient programmes for the enhancement of cognitive performance in elderly with and without cognitive decline. Conclusion: The application of a non-pharmacological approach in the treatment of elderly with cognitive disorders could have a profound impact on National Health Service. © 2016 The Author(s) Source

Malavolta M.,Nutrition and Aging Center | Basso A.,Nutrition and Aging Center | Piacenza F.,Nutrition and Aging Center | Giacconi R.,Nutrition and Aging Center | And 3 more authors.
Rejuvenation Research

The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice. © 2012 Mary Ann Liebert, Inc. Source

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