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News Article | November 2, 2016
Site: www.eurekalert.org

Scientists from the UGR, the CIDAF, and the Richardson Centre for Functional Foods and Nutraceuticals at Canada have proven that the consumption of high oleic canola oil enriched with Omega-3 reduces the concentration of triglycerides in the blood A team of scientists from the University of Granada (UGR), the Research and Development Functional Food Centre (CIDAF, from its abbreviation in Spanish, centre in which the UGR collaborates with other companies and institutions) and the Richardson Centre for Functional Foods and Nutraceuticals at Canada has shown that consuming canola oil (an improved form of rapeseed, with less than 2% erucic acid) enriched with Omega-3 reduces the risk of cardiovascular disease. Researchers have once again proven that the famous Omega-3 is a potent regulator of cholesterol metabolism. This time, scientists analyzed the plasma from 84 volunteer patients, who presented at least one symptom of metabolic syndrome, after eating different types of oils with different fatty acid composition. That way, they found that said fatty acid reduces the PCSK9 concentration in plasma. PCSK9 is a protein associated with high levels of LDL cholesterol in blood and with other cardiovascular diseases. The consumption of high oleic, Omega-3 enriched canola oil not only significantly reduced the concentration of triglycerides, but also resulted in a significant reduction (a 10%) of the PCSK9 protein concentration in plasma, compared to the other dietary treatments. The mechanism of action of this protein is based on the destruction of the receptors of LDL cholesterol, preventing the uptake of LDL by the cells and increasing their plasma concentrations, resulting in an increased risk of atherosclerosis and other related diseases. These results, from the trial called "Canola Oil Multicentre Trial Intervention (COMIT)", represent the first line of scientific evidence on changes in the PCSK9 protein plasma concentration after ingestion of different types of fat from the diet. "In conclusion, we can state that although the mechanism of action for the consumption of different fatty acids on plasma concentrations of PCSK9 is being investigated, we should not forget the importance of dietary fat in the prevention of the risk of cardiovascular diseases" Celia Rodríguez, UGR and CIDAF researcher, lead author of the study, says. The results from this work have been presented at the Conference from International Academy of Nutrition and Aging and the International Experimental Biology Conference, and they have been published in two international journals: Lipids and Vascular Pharmacology.


Giacconi R.,Nutrition and Aging | Kanoni S.,Harokopio University | Mecocci P.,University of Perugia | Malavolta M.,Nutrition and Aging | And 13 more authors.
Journal of Nutritional Biochemistry | Year: 2010

Metallothioneins (MT), the antioxidant zinc-binding proteins, seem to mediate cardioprotection. It has been postulated that zinc homeostasis and MT function may be altered, as a consequence of oxidative stress, in cardiovascular disease (CVD), with a potential implication of MT genetic polymorphisms. The present study explores the role of +647A/C and +1245A/G MT1A polymorphisms on the susceptibility to CVD, zinc status and enzyme antioxidant activity, in the Greek and Italian populations. The country selection was based on the lower zinc status and the reduced zinc dietary intake in Greece than in Italy despite the similar Mediterranean dietary pattern. A total of 464 old, healthy control subjects and 369 old CVD patients more than 70 years of age were studied. Logistic regression model indicated that +1245 MT1A G+ genotype significantly increased the risk of CVD in Greece (34.4% vs 23.2%; odds ratio=1.88, 95% confidence interval=1.14-3.08; P=013) but not in Italy. Haplotype analysis showed an increment of CG haplotype frequency in CVD Greek patients (17.4% vs. 10.6%, P<05). Differential country-related frequency distribution was also recorded. Applying a multivariate regression model, +647/+1245 MT1A haplotype was associated with a modulation of enzyme antioxidant activities in both countries. Decreased plasma zinc and reduced intracellular Zn release, as well as increased enzyme antioxidant activity, were more apparent in Greek healthy donors than in Italy. In conclusion, +1245 MT1A polymorphism and +647/+1245 MT1A haplotype are implicated in CVD in Greece but not in Italy, suggesting a role of gene-diet interaction in the disease predisposition. © 2010 Elsevier Inc.


PubMed | Nutrition and Aging
Type: Comparative Study | Journal: The Journal of nutritional biochemistry | Year: 2010

Metallothioneins (MT), the antioxidant zinc-binding proteins, seem to mediate cardioprotection. It has been postulated that zinc homeostasis and MT function may be altered, as a consequence of oxidative stress, in cardiovascular disease (CVD), with a potential implication of MT genetic polymorphisms. The present study explores the role of +647A/C and +1245A/G MT1A polymorphisms on the susceptibility to CVD, zinc status and enzyme antioxidant activity, in the Greek and Italian populations. The country selection was based on the lower zinc status and the reduced zinc dietary intake in Greece than in Italy despite the similar Mediterranean dietary pattern. A total of 464 old, healthy control subjects and 369 old CVD patients more than 70 years of age were studied. Logistic regression model indicated that +1245 MT1A G+ genotype significantly increased the risk of CVD in Greece (34.4% vs. 23.2%; odds ratio=1.88, 95% confidence interval=1.14-3.08; P=.013) but not in Italy. Haplotype analysis showed an increment of CG haplotype frequency in CVD Greek patients (17.4% vs. 10.6%, P<.05). Differential country-related frequency distribution was also recorded. Applying a multivariate regression model, +647/+1245 MT1A haplotype was associated with a modulation of enzyme antioxidant activities in both countries. Decreased plasma zinc and reduced intracellular Zn release, as well as increased enzyme antioxidant activity, were more apparent in Greek healthy donors than in Italy. In conclusion, +1245 MT1A polymorphism and +647/+1245 MT1A haplotype are implicated in CVD in Greece but not in Italy, suggesting a role of gene-diet interaction in the disease predisposition.

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