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Visen P.K.S.,Nutra Canada | Visen P.K.S.,University of Toronto | Visen A.S.,St. Matthews University | Visen S.S.,University of Toronto | And 2 more authors.
World Heart Journal | Year: 2015

Background: Recent epidemiological studies predict that the worldwide incidence of type 2 diabetes, atherosclerosis, and cardiovascular diseases are increasing at an alarming rate. Currently, limited cures are available to prevent or cure diabetes and related postprandial glycemia, atherosclerosis and cardiovascular diseases. Insufficiency of current therapies for the treatment of type 2 diabetes and atherosclerosis, combined with both the lack of patient trust in conventional medical treatment and inability of the economy to absorb the cost of synthetic pharmaceuticals, have created a growing public interest in the use of Complementary and Alternative Medicines (CAM). Especially dietary and herbal remedies have become more popular because of their therapeutic effectiveness, relatively lesser or no side effects and low cost. Methods: Our publications, internet search of research articles from Pub Med and University of Toronto library, as well as discussions with nutritional scientists and basic researchers. Results: Unfortunately, the vast majority of herbal remedies lack quality control, standardization, and clinical scrutiny for treatment of ailments. Thus patients continue self-medicating with herbal products with little or no evidence of their safety and efficacy. WHO study groups strongly emphasize the optimal and rational uses of traditional medicines. Regulatory agencies like Food Trade Commission, Food & Drug Administration of USA, and Health Canada are deeply concerned about the effectiveness and safety of natural health products and alternative therapies. The increasingly high demand of CAM, in the absence of evidence-based safety and efficacy, adequate regulatory standards, patient disclosures to physicians and physician education, have prompted a unified call from the medical and scientific community for randomized controlled clinical trials of herbal medicines, dietary supplements and functional foods, in order to understand their therapeutic potential and to provide a valid basis for legitimate health promotion claims. Several researchers have developed and standardized scientific models (randomized, double blind, crossover, placebo-controlled clinical trials) for faster and cost-effective clinical validation of medicinal herbs and functional foods for their application in the management of type 2 diabetes using 2-hour oral glucose tolerance test. This scientific approach has been strongly recommended in this communication. The management and prevention of atherosclerosis, diabetes-linked cardiovascular diseases, and metabolic syndrome should be done by following healthy life styles, dietary interventions, nutraceutical therapies, and alternative medicines as discussed in this review. Conclusion: The reviewed information may not only provide the rationale of proposing the scientific models for clinical testing of CAM therapies, but would also be beneficial in managing type 2 diabetes and atherosclerosis effectively. © 2015 Nova Science Publishers, Inc. Source

Heim K.C.,Pure Encapsulations Inc | Angers P.,Laval University | Leonhart S.,Nutra Canada | Ritz B.W.,Atrium Innovations
Journal of Medicinal Food | Year: 2012

Epidemiological evidence supports inverse associations between fruit and vegetable intake and incidence of cardiovascular disease and neurodegeneration. Dietary botanicals with salient health benefits include berries and leafy vegetables. Molecular pharmacology research has ascribed these benefits primarily to phenolic constituents and antioxidant activity. The current investigation sought to eluicidate pharmacologic activity of two novel preparations of berry and spinach extracts in vitro. Blueberry and cranberry exhibited the greatest antioxidant activity. In a dose-dependent manner, a proprietary mixture of cranberry and blueberry extracts inhibited inhibitor of κB kinase β, a central node in inflammatory signal transduction. A proprietary mixture of blueberry, strawberry, and spinach extracts inhibited prolyl endopeptidase, a regulator of central neuropeptide stability and an emerging therapeutic target in neurology and psychiatry. These results indicate specific molecular targets of blended dietary plants with potential relevance to inflammation and neurological health. © Copyright 2012, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2012. Source

Nutra Canada | Date: 2013-10-02

Concentrated extracts, in dry or liquid form, of cranberries and plant rich in polyphenols and other bioactive molecules used for the treatment, promotion and maintenance of urinary tract health and other mucosa for human and animal use.

Nutra Canada | Date: 2013-10-02

Concentrated extracts, in dry or liquid form, of grapes, blueberries and plant rich in polyphenols and other bioactive molecules used for the treatment, promotion and maintenance of cognitive and mental health for human and animal use.


Nutra Canada | Date: 2013-10-03

Dietary and nutritional supplements for human or animal general health and well-being namely, dietary and nutritional supplements in the form of powdered drink mixes, tablets, bars, powders, nutritional drinks, and liquid drink mixes; Dietary supplements for treatment and prevention of human or pet/animal diseases, disorders and conditions, namely, allergic diseases, cognitive, autoimmune and inflammatory diseases; Dietary supplements for human or animal consumption and maintain good health; Nutraceuticals for use as a dietary supplement for human or animal; Dietary supplements adapted for medical or veterinarian purposes; High concentrated extracts from fruits and vegetables for use as a dietary supplements for human or animal; Food ingredients consisting primarily of extracts of fruits vegetables and plant and extracts; Active cosmetic components made from extracts of fruits, vegetables and plant extracts. Consulting services regarding research and development, formulation development, quality control, clinical evaluation, regulatory registration, manufacture, marketing, and sales in the field of natural health products, cosmetics ingredients, nutritional extracts and pharmaceuticals; Scientific research and development in the field of plant and fruit nutritional science, natural products science, food science and human and animal food nutrition; Nutraceutical, cosmetic, dietary and nutritional supplements research services; Biological research; Scientific research and development of high quality extracts from fruits and vegetables; Production of high quality extracts from fruits and vegetables for others; Research and development of new products and technologies for others in the field of biotechnology; Technical and scientific consultancy in relation to extraction of high concentrated extracts of fruits and vegetables.

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