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Vasquez S.X.,Numira Biosciences | Gao F.,University of California at Los Angeles | Su F.,University of California at Los Angeles | Grijalva V.,University of California at Los Angeles | And 8 more authors.
PLoS ONE | Year: 2011

Vascular networks within a living organism are complex, multi-dimensional, and challenging to image capture. Radio-angiographic studies in live animals require a high level of infrastructure and technical investment in order to administer costly perfusion mediums whose signals metabolize and degrade relatively rapidly, diminishing within a few hours or days. Additionally, live animal specimens must not be subject to long duration scans, which can cause high levels of radiation exposure to the specimen, limiting the quality of images that can be captured. Lastly, despite technological advances in live-animal specimen imaging, it is quite difficult to minimize or prevent movement of a live animal, which can cause motion artifacts in the final data output. It is demonstrated here that through the use of postmortem perfusion protocols of radiopaque silicone polymer mediums and ex-vivo organ harvest, it is possible to acquire a high level of vascular signal in preclinical specimens through the use of micro-computed tomographic (microCT) imaging. Additionally, utilizing high-order rendering algorithms, it is possible to further derive vessel morphometrics for qualitative and quantitative analysis. © 2011 Vasquez et al.


Vasquez S.X.,Numira Biosciences | Shah N.,Numira Biosciences | Hoberman A.M.,Charles River Laboratories
Methods in Molecular Biology | Year: 2013

Micro-computed tomography imaging technology allows for the whole-mount investigation of skeletal structures in preclinical specimens at both fetal and postnatal time points. The imaging process is nondestructive to the specimen and can be performed at various resolutions to derive the region of interest information most relevant to individual researchers. In addition to qualitative imaging of skeletal samples, accurate and desirable metrics such as bone mineral density (BMD), discrete cortical and trabecular bone analysis, and milligrams hydroxyapatite per unit volume (mgHA/cc) are also achievable depending upon scanner platform. Additional benefits to the method include digitally archivable files, in vivo and ex vivo scanning options, and volumetric or slice-thru presentation of data in standard histological or oblique orientations. Some drawbacks to the method include long scan times at higher spatial resolutions, large file sizes, and limitation to imaging of highly dense biological structures (i.e., bone), though several groups have attempted to expand the modality to include soft tissue imaging in ex vivo specimens. © 2013 Springer Science+Business Media, LLC.


Patent
Numira Biosciences | Date: 2013-09-06

The present disclosure relates in general to methods for staining and imaging lung specimens for the purpose of quantifying fibrotic areas of the lung. Images according to the present invention include images obtained from X-ray microcomputed tomography.


System and methods for software evaluation in a cloud computing environment are disclosed. In some implementations, a method includes: at a computer system, maintaining session information for a plurality of remote user sessions between one or more users and the computer system and formatting for display a plurality of graphical representations corresponding to the plurality of remote user sessions. A respective graphical representation in the plurality of graphical representations indicates a current or historical state of a corresponding remote user session, in the plurality of remote user sessions. The method further includes obtaining a user selection of a graphical representation in the plurality of graphical representations. In response to user selection of the graphical representation, a session is established between a client device associated with the user and the computer system and the session is initiated in the state as indicated in the graphical representation.


A method for project collaboration includes: at a computer system, hosting a collaboration software application and a plurality of data sets associated with the collaboration software application; establishing a first remote user session between the computer system and a first client device running on a first operating system; wherein the first client device is associated with a first user; establishing a second remote user session between the computer system and a second client device running on a second operation system, distinct from the first operating system; wherein the second client device is associated with a second user distinct from the first user; merging the first remote user session and the second remote user session into a single remote user session; and enabling, using the single remote user session, the first user and the second user to concurrently control the collaboration software application and the plurality of data sets.


Patent
Numira Biosciences | Date: 2010-08-02

The near-infrared wavelengths (700 nm-900 nm) are a suitable optical window for light penetration and deep tissue imaging. The present invention provides a near-infrared fluorescent blood pool contrast agent. The agent is of use to detect and quantify pathological capillary leak in live animals, e.g., serially imaging of traumatized tissue (muscle) as well as tumors.


Patent
Numira Biosciences | Date: 2010-01-08

The present invention relates in general to compositions, processes and apparatus for imaging, and in particular for improved preparation, collection and processing of images of specimens that include cartilage, particularly specimens of intact or disarticulated joints. Images of specimens according to the present invention include images obtained from X-ray microscopic computed tomography.


Patent
Numira Biosciences | Date: 2010-01-08

The present invention relates in general to compositions, processes and apparatus for imaging, and in particular for preparation, collection and processing of images of atherosclerotic plaques, including images obtained from X-ray microscopic computed tomography.


Patent
Numira Biosciences | Date: 2012-06-06

The present invention provides an animal toxicity model that can be used to screen agents that may cause or increase the occurrence of a developmental defect. The invention also provides methods and compositions for creating such an animal toxicity model, as well as methods and kits for using these animal models.


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