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Kassin S.A.,Goddard Space Flight Center | Devriendt J.,University of Oxford | Fall S.M.,US Space Telescope Science Institute | de Jong R.S.,Leibniz Institute for Astrophysics Potsdam | And 3 more authors.
Monthly Notices of the Royal Astronomical Society | Year: 2012

In the standard picture of disc galaxy formation, baryons and dark matter receive the same tidal torques, and therefore approximately the same initial specific angular momentum. However, observations indicate that disc galaxies typically have only about half as much specific angular momentum as their dark matter haloes. We argue this does not necessarily imply that baryons lose this much specific angular momentum as they form galaxies. It may instead indicate that galaxies are most directly related to the inner regions of their host haloes, as may be expected in a scenario where baryons in the inner parts of haloes collapse first. A limiting case is examined under the idealized assumption of perfect angular momentum conservation. Namely, we determine the density contrast Δ, with respect to the critical density of the Universe, by which dark matter haloes need to be defined in order to have the same average specific angular momentum as the galaxies they host. Under the assumption that galaxies are related to haloes via their characteristic rotation velocities, the necessary Δ is ∼600. This Δ corresponds to an average halo radius and mass which are ∼60per cent and ∼75per cent, respectively, of the virial values (i.e. for Δ= 200). We refer to this radius as the radius of baryonic collapse R BC, since if specific angular momentum is conserved perfectly, baryons would come from within it. It is not likely a simple step function due to the complex gastrophysics involved; therefore, we regard it as an effective radius. In summary, the difference between the predicted initial and the observed final specific angular momentum of galaxies, which is conventionally attributed solely to angular momentum loss, can more naturally be explained by a preference for collapse of baryons within R BC, with possibly some later angular momentum transfer. © 2012 The Authors Monthly Notices of the Royal Astronomical Society © 2012 RAS.


Klock C.,Stanford University | Jin X.,Stanford University | Choi K.,Stanford University | Khosla C.,Stanford University | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

Inhibitors of human transglutaminase 2 (TG2) are anticipated to be useful in the therapy of a variety of diseases including celiac sprue as well as certain CNS disorders and cancers. A class of 3-acylidene-2-oxoindoles was identified as potent reversible inhibitors of human TG2. Structure-activity relationship analysis of a lead compound led to the generation of several potent, competitive inhibitors. Analogs with significant non-competitive character were also identified, suggesting that the compounds bind at one or more allosteric regulatory sites on this multidomain enzyme. The most active compounds had Ki values below 1.0 μM in two different kinetic assays for human TG2, and may therefore be suitable for investigations into the role of TG2 in physiology and disease in animals. © 2010 Elsevier Ltd. All rights reserved.


A system, method, and computer program product are provided for identifying a first markup document including first numerical values and first tags reflecting first characteristics of the first numerical values associated with a first unit of measure, and a second markup document including second numerical values and second tags reflecting second characteristics of the second numerical values associated with a second unit of measure. The first characteristics of the first numerical values associated with the first unit of measure are different from the second characteristics of the second numerical values associated with the second unit of measure. At least a portion of the numerical values of at least one of the first markup document or the second markup document are automatically transformed, so that the at least some of the first numerical values of the first markup document and at least some of the second numerical values of the second markup document have a common unit of measure. Further, at least a part of the first markup document and at least a part of the second markup document are processed, resulting in a single markup document, for display.


A system, method, and computer program product are provided for use in connection with at least one computer-readable Extensible Markup Language (XML)-compliant data document capable of including: a plurality of line items with a plurality of data values, and a plurality of computer-readable semantic tags that describe a semantic meaning of the data values.


A system, method, and computer program product are provided for use in connection with at least one computer-readable Extensible Markup Language (XML)-compliant data document capable of including: a plurality of line items with a plurality of data values, and a plurality of computer-readable semantic tags that describe a semantic meaning of the data values.


Patent
Numerate | Date: 2012-03-06

Methods and articles of manufacture for modeling molecular properties using data regarding the partial orderings of compound properties, or by considering measurements of compound properties in terms of partial orderings are disclosed. One embodiment provides for constructing such partial orderings from data that is not already in an ordered form by processing training data to produce a partial ordering of the compounds with respect to a property of interest. Another embodiment of the invention may process the modified training data to construct a model that predicts the property of interest for arbitrary compounds.


A system, method, and computer program product are provided for use in connection with at least one computer-readable Extensible Markup Language (XML)-compliant data document capable of including: a plurality offline items with a plurality of data values, and a plurality of computer-readable semantic tags that describe a semantic meaning of the data values.


Patent
Numerate | Date: 2010-03-03

Methods and articles of manufacture for modeling molecular properties using data regarding the partial orderings of compound properties, or by considering measurements of compound properties in terms of partial orderings are disclosed. One embodiment provides for constructing such partial orderings from data that is not already in an ordered form by processing training data to produce a partial ordering of the compounds with respect to a property of interest. Another embodiment of the invention may process the modified training data to construct a model that predicts the property of interest for arbitrary compounds.


News Article | June 24, 2014
Site: www.finsmes.com

The round was co-led by Atlas Venture and Lilly Ventures, with participation from existing investors. In conjunction with the funding, Bruce Booth, Ph.D, Partner at Atlas Venture, and Steve Hall, Ph.D., Venture Partner at Lilly Ventures, joined Numerate’s Board of Directors. The company intends to use the funds to advance its lead programs. Led by Guido Lanza, president and chief executive officer, Numerate has developed a drug design platform that uses all relevant data (SAR, patents, phenotypic data, etc.) to treat cardiovascular, metabolic and neurodegenerative diseases. In metabolic disease, the company is targeting the free fatty acid receptors to address diabetes, obesity and related co-morbidities, while in cardiovascular disease they are targeting the Ryanodine receptor 2 to discover improved drugs for heart failure and arrhythmia.

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