Copenhagen, Denmark
Copenhagen, Denmark

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Patent
Nuevolution | Date: 2017-06-07

Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy.


Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.


Patent
Nuevolution | Date: 2016-10-13

The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.


Patent
Nuevolution | Date: 2014-12-16

The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.


Patent
Nuevolution | Date: 2014-07-24

The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.


Patent
Nuevolution | Date: 2016-09-21

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.


Patent
Nuevolution | Date: 2015-09-22

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.


Patent
Nuevolution | Date: 2013-12-06

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.


The present invention is in the field of split-and-mix library synthesis and is directed to a method for splitting a library synthesized by a split-and-mix synthesis strategy. The splitting of the library is performed based on nucleic acid tag sequence hybridization post library synthesis. In a first library synthesis step, nascent bifunctional complexes are dispensed in separate compartments and exposed to a different reactant in each compartment. Then, in each compartment, a different reactant reacts with at least one reactive group of a chemical reaction site of a nascent bifunctional complex, and a nucleic acid tag identifying the reactant is added by enzymatic action at a priming site of the nascent bifunctional complex. The library is then split by nucleic acid hybridization based on the sequence of different synthesis directing nucleic acid tags attached to the split-and-mix library members. The present invention combines split-and-mix library synthesis with an amplification of the synthesized library.


Patent
Nuevolution | Date: 2015-07-08

Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.

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