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Razjouyan J.,Islamic Azad University at Garmsar | Zolata H.,Amirkabir University of Technology | Khayat O.,Islamic Azad University at Tehran | Nowshiravan F.,Islamic Azad University at Tehran | And 2 more authors.
Nukleonika | Year: 2015

To design a potent agent for positron emission tomography/magnetic resonance imaging (PET/MRI) imaging and targeted magnetic hyperthermia-radioisotope cancer therapy radiolabeled surface modified superparamagnetic iron oxide nanoparticles (SPIONs) were used as nanocarriers. Folic acid was conjugated for increasing selective cellular binding and internalization through receptor-mediated endocytosis. SPIONs were synthesized by the thermal decomposition of tris (acetylacetonato) iron (III) to achieve narrow and uniform nanoparticles. To increase the biocompatibility of SPIONs, they were coated with (3-aminopropyl) triethoxysilane (APTES), and then conjugated with synthesized folic acid-polyethylene glycol (FA-PEG) through amine group of (3-aminopropyl) triethoxysilane. Finally, the particles were labeled with 64Cu (t1/2 = 12.7 h) using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxy succinimide ester) DOTA-NHS chelator. After the characterization of SPIONs, their cellular internalization was evaluated in folate receptor (FR) overexpressing KB (established from a HeLa cell contamination) and mouse fibroblast cell (MFB) lines. Eventually, active and passive targeting effects of complex were assessed in KB tumor-bearing Balb/C mice through biodistribution studies. Synthesized bare SPIONs had low toxicity effect on healthy cells, but surface modification increased their biocompatibility. Moreover, KB cells viability was reduced when using folate conjugated SPIONs due to FR-mediated endocytosis, while having little effect on healthy cells (MFB). Moreover, this radiotracer had tolerable in vivo characteristics and tumor uptake. In the receptor blocked case, tumor uptake was decreased, indicating FR-specific uptake in tumor tissue while enhanced permeability and retention effect was major mechanism for tumor uptake. Source


Hassani Bidaroni H.,Islamic Azad University at Tehran | Mirzaii M.,Nuclear Medicine Research Group
Heat and Mass Transfer/Waerme- und Stoffuebertragung | Year: 2014

The lattice Boltzmann equation method in three dimensions used to analyze compressible thermal flow in 30 MeV cyclotrons. Cyclotron produced radionuclides have diagnostic applications in nuclear medicine. This cyclotron has horizontal conically shaped and window air cooling in the front and water cooling of the body. Gas heated by irradiation. This scheme is a new type of simulation method for solving the time dependent Navier-Stokes equations in a compressible flow regime. The improved model is convenient to compromise the high accuracy and stability. The included dispersion term can effectively reduce the numerical oscillation at discontinuity. The lattice Boltzmann scheme with uniform mesh resolution is applied as a numerical research tool. © 2014 Springer-Verlag Berlin Heidelberg. Source


Hassani Bidaroni H.,Islamic Azad University at Tehran | Sardari D.,Islamic Azad University at Tehran | Mirzaee M.,Nuclear Medicine Research Group | Moattar F.,Islamic Azad University at Tehran
Life Science Journal | Year: 2012

We have studied the effect of beam intensity on physical properties of gas target. The high-energy proton beam (12 μA) which was produced in cyclotron of nuclear medicine research group at the Agricultural, Medical and Industrial Research School (AMIRS) entered a conical stainless steel target chamber through a titanium double window. CFD has been used for numerical study of thermal field inside the gas target for three different cases of helium, nitrogen and krypton. The results of both numerical and experimental investigations reveal that target pressure and temperature increase with increasing the beam intensity. Target pressure increasing rate, raises with increasing of gas molecular weight (Kr>N2>He). Source


Fazaeli Y.,Nuclear Medicine Research Group | Fazaeli Y.,Shahid Beheshti University | Jalilian A.R.,Nuclear Science and Technology Research Institute, Iran | Amini M.M.,Shahid Beheshti University | And 4 more authors.
Journal of Radioanalytical and Nuclear Chemistry | Year: 2013

Cu-64 was produced via the 68Zn (p,αn)64Cu nuclear reaction (≈200 mCi, >95 % chemical yield at 180 μA for 1.1 h irradiation, (radionuclidic purity >96 %, copper-67 as impurity) followed by purification with amino functionalized nano magnetic oxide, Fe3O 4 aiming to remove trace amount of heavy metal ions from aqueous media due to achieve ultra pure [64Cu] CuCl2 for labeling step. [64Cu] labeled 5,10,15,20-tetrakis(penta fluoro phenyl) porphyrin ([64Cu]-TFPP) was prepared using freshly prepared [ 64Cu] CuCl2 (Cu-64; T 1/2 = 12.7 h) and 5,10,15,20-tetrakis(penta fluoro phenyl)porphyrin (H2TFPP) for 60 min at 100 °C under reflux condition (radiochemical purity: >97 % ITLC, >98 % HPLC, specific activity: 14-16 GBq/mmol). Stability of the complex was checked in final formulation and human serum for 24 h. The partition coefficient was calculated for the compound (log P = 0.73). The biodistribution of the labeled compound in vital organs of wild-type rats was studied using scarification studies and PET imaging up in 2 and 4 h after injection. A detailed comparative pharmacokinetic study performed for 64Cu cation and [64Cu]-TFPP. The complex is mostly washed out from the circulation through kidneys and liver and can be an interesting tumor imaging/targeting agent due to high specific uptake and rapid excretion through the urinary tract. © 2012 Akadémiai Kiadó, Budapest, Hungary. Source


Aboudzadeh M.,Nuclear Medicine Research Group | Fazaeli Y.,Nuclear Medicine Research Group | Khodaverdi H.,University of Tehran | Afarideh H.,University of Tehran
Journal of Radioanalytical and Nuclear Chemistry | Year: 2013

[140Nd] labeled 5,10,15,20-tetraphenylporphyrin ([ 140Nd]-TPP) as a tumor-avid complex with a β-emitting radionuclide for evaluating its potential for target tumor therapy is reported. This complex was prepared using freshly prepared [140Nd] NdCl 3 (purified by amino functionalized MCM-41 nano resin and commercial cation exchanger resins) and 5,10,15,20-tetraphenylporphyrin (H 2TPP).Stability of the complex was investigated in final formulation and human serum for 24 h and the partition coefficient was calculated. The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibro sarcoma tumor was studied using scarification studies and positron emission tomography imaging up to 4 h. © 2012 Akadémiai Kiadó, Budapest, Hungary. Source

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