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News Article | May 11, 2017
Site: www.eurekalert.org

Tumors, inflammation and circulatory disorders locally disturb the body's acid-base balance. These changes in pH value could be used for example to verify the success of cancer treatments. Up to now, however, there has been no imaging method to render such changes visible in patients. Now a team from the Technical University of Munich (TUM) has developed a pH sensor that renders pH values visible through magnetic resonance imaging (MRI) - in a non-invasive, radiation-free manner. Four years ago, during a magnetic resonance experiment with tumor cells, TUM physicist Dr. Franz Schilling found signals from a molecule that was highly sensitive towards pH changes. The molecule, which was identified as zymonic acid in subsequent investigations, could play an important role in the future of medical imaging. As a biosensor for pH values, it could provide insights into the body which had been impossible in the past. "An appropriate pH imaging method would make it possible to visualize abnormal changes in tissue and specifically metabolic processes of tumors," explains Franz Schilling. Areas surrounding tumors and inflammations are usually slightly more acidic than areas surrounding healthy tissue, a phenomenon possibly linked to the aggressiveness of tumors. Schilling sees further potential uses in treatment prognoses: "pH values are also interesting when it comes to evaluating the efficacy of tumor treatments. Even before a successfully treated tumor starts to shrink, its metabolism and thus the pH value of the surrounding area could change. An appropriate pH imaging method would indicate at a much earlier stage whether or not the right approach has been selected." Schilling is now Director of the working group for Preclinical Imaging and Medical Physics at the Clinic and Polyclinic for Nuclear Medicine in the TUM Klinikum rechts der Isar. In past years, he has joined together with colleagues from the departments of Physics, Chemistry and Medicine to research zymonic acid as a biosensor. In the journal Nature Communications the team describes how it can be used to reliably represent pH values in the bodies of small animals. In order to make pH values visible using zymonic acid, the molecule is injected into the body and then a magnetic resonance imaging (MRI) investigation is made of the object tissue. In greatly simplified terms: In a strong magnetic field, radiowaves excite the nuclear spins of the zymonic acid to oscillation. The reactions of the nuclei are then recorded. This data is used to calculate frequency spectra that in turn provide information about the chemical properties of the molecular surroundings of the nuclei. Ultimately, the pH value at any examined location in the tissue can be represented based on pH-dependent molecular changes in the zymonic acid. Zymonic acid has to be marked with carbon 13 in order to be visible in MRI images. This means that the molecules contain carbon 13 atoms (13C) instead of "normal" carbon 12 atoms. But zymonic acid marked in this manner is still not measurable: its MRI signal is too weak. "We therefore use a relatively new method, hyperpolarization," explains Stephan Düwel, physicist and first author of the study. "We use a special device to transfer the polarization of electrons to the 13C atomic nuclei using microwaves at very low temperatures, which results in an MRI signal up to 100,000 times stronger." A hot liquid is then used to quickly return the zymonic acid to room temperature. After this, the scientists need to act quickly. The biosensor is injected intravenously into the organism, then the MRI scan has to be made immediately: It only takes 60 seconds for the signal-amplifying effect of the hyperpolarization to wear off again. "We're currently working on expanding this time window," says Düwel. "On the one hand, we're trying to improve the MRI properties of zymonic acid with appropriate modifications to the molecule; On the other hand, we're looking for other pH-sensitive molecules," explains biochemist Christian Hundshammer, second author of the study. Franz Schilling and his team have succeeded in showing that their method is sensitive enough to represent medically relevant pH value changes in the organism. Using zymonic acid it is furthermore possible to specifically investigate the pH value outside of the cell membrane: With other biosensors it is often not clear whether measured changes take place inside or outside of the cell (intracellular or extracellular). This is important because the intracellular value is usually stable, while changes in metabolism have a much greater impact on the extracellular value. In contrast to optical methods, which are limited to superficial penetration into the body because of the low transparency of tissue, there are no limitations to the depth of penetration for MRI. It has furthermore been demonstrated that zymonic acid is not toxic in the concentrations used with small animals and is also created in low concentrations as a by-product of the metabolite pyruvic acid which is present in the body. "We believe zymonic acid is a highly promising biosensor for patient applications," says Franz Schilling. For the time being, however, additional pre-clinical studies are planned in order to ascertain the advantages of this new imaging biomarker compared to conventional methods and to further improve the spatial resolution of pH imaging. The research project was funded by the Collaborative Research Centre 824 (SFB824) "Imaging for Selection, Monitoring and Individualization of Cancer Therapies" led by Prof. Markus Schwaiger. S. Düwel, C. Hundshammer, M. Gersch, B. Feuerecker, K. Steiger, A. Buck, A. Walch, A. Haase, S. J. Glaser, M. Schwaiger, F. Schilling, "Imaging of pH in vivo using hyperpolarized 13C-labeled zymonic acid". Nature Communications (2017). Doi: 10.1038/NCOMMS15126 F. Schilling, S. Düwel, U. Köllisch, M. Durst, R.F. Schulte, S.J. Glaser, A. Haase, A.M. Otto, M.I. menzel. "Diffusion of hyperpolarized 13C-metabolites in tumor cell spheroids using real-time NMR spectroscopy". NMR Biomed., 26:5 (2013) 557-568. doi:10.1002/nbm.2892


News Article | May 11, 2017
Site: phys.org

Four years ago, during a magnetic resonance experiment with tumor cells, TUM physicist Dr. Franz Schilling found signals from a molecule that was highly sensitive towards pH changes. The molecule, which was identified as zymonic acid in subsequent investigations, could play an important role in the future of medical imaging. As a biosensor for pH values, it could provide insights into the body which had been impossible in the past. "An appropriate pH imaging method would make it possible to visualize abnormal changes in tissue and specifically metabolic processes of tumors," explains Franz Schilling. Areas surrounding tumors and inflammations are usually slightly more acidic than areas surrounding healthy tissue, a phenomenon possibly linked to the aggressiveness of tumors. Schilling sees further potential uses in treatment prognoses: "pH values are also interesting when it comes to evaluating the efficacy of tumor treatments. Even before a successfully treated tumor starts to shrink, its metabolism and thus the pH value of the surrounding area could change. An appropriate pH imaging method would indicate at a much earlier stage whether or not the right approach has been selected." Schilling is now Director of the working group for Preclinical Imaging and Medical Physics at the Clinic and Polyclinic for Nuclear Medicine in the TUM Klinikum rechts der Isar. In past years, he has joined together with colleagues from the departments of Physics, Chemistry and Medicine to research zymonic acid as a biosensor. In the journal Nature Communications the team describes how it can be used to reliably represent pH values in the bodies of small animals. In order to make pH values visible using zymonic acid, the molecule is injected into the body and then a magnetic resonance imaging (MRI) investigation is made of the object tissue. In greatly simplified terms: In a strong magnetic field, radiowaves excite the nuclear spins of the zymonic acid to oscillation. The reactions of the nuclei are then recorded. This data is used to calculate frequency spectra that in turn provide information about the chemical properties of the molecular surroundings of the nuclei. Ultimately, the pH value at any examined location in the tissue can be represented based on pH-dependent molecular changes in the zymonic acid. Zymonic acid has to be marked with carbon 13 in order to be visible in MRI images. This means that the molecules contain carbon 13 atoms (13C) instead of "normal" carbon 12 atoms. But zymonic acid marked in this manner is still not measurable: its MRI signal is too weak. "We therefore use a relatively new method, hyperpolarization," explains Stephan Düwel, physicist and first author of the study. "We use a special device to transfer the polarization of electrons to the 13C atomic nuclei using microwaves at very low temperatures, which results in an MRI signal up to 100,000 times stronger." A hot liquid is then used to quickly return the zymonic acid to room temperature. After this, the scientists need to act quickly. The biosensor is injected intravenously into the organism, then the MRI scan has to be made immediately: It only takes 60 seconds for the signal-amplifying effect of the hyperpolarization to wear off again. "We're currently working on expanding this time window," says Düwel. "On the one hand, we're trying to improve the MRI properties of zymonic acid with appropriate modifications to the molecule; On the other hand, we're looking for other pH-sensitive molecules," explains biochemist Christian Hundshammer, second author of the study. Franz Schilling and his team have succeeded in showing that their method is sensitive enough to represent medically relevant pH value changes in the organism. Using zymonic acid it is furthermore possible to specifically investigate the pH value outside of the cell membrane: With other biosensors it is often not clear whether measured changes take place inside or outside of the cell (intracellular or extracellular). This is important because the intracellular value is usually stable, while changes in metabolism have a much greater impact on the extracellular value. In contrast to optical methods, which are limited to superficial penetration into the body because of the low transparency of tissue, there are no limitations to the depth of penetration for MRI. It has furthermore been demonstrated that zymonic acid is not toxic in the concentrations used with small animals and is also created in low concentrations as a by-product of the metabolite pyruvic acid which is present in the body. "We believe zymonic acid is a highly promising biosensor for patient applications," says Franz Schilling. For the time being, however, additional pre-clinical studies are planned in order to ascertain the advantages of this new imaging biomarker compared to conventional methods and to further improve the spatial resolution of pH imaging. More information: S. Düwel, C. Hundshammer, M. Gersch, B. Feuerecker, K. Steiger, A. Buck, A. Walch, A. Haase, S. J. Glaser, M. Schwaiger, F. Schilling, "Imaging of pH in vivo using hyperpolarized 13C-labeled zymonic acid". Nature Communications (2017). DOI: 10.1038/NCOMMS15126 F. Schilling, S. Düwel, U. Köllisch, M. Durst, R.F. Schulte, S.J. Glaser, A. Haase, A.M. Otto, M.I. menzel. "Diffusion of hyperpolarized 13C-metabolites in tumor cell spheroids using real-time NMR spectroscopy". NMR Biomed., 26:5 (2013) 557–568. DOI: 10.1002/nbm.2892


News Article | May 22, 2017
Site: www.businesswire.com

INDIANAPOLIS--(BUSINESS WIRE)--Zotec Partners (Zotec), the industry leader in radiology revenue cycle and practice management services, announces a renewed revenue cycle management agreement with Georgetown Radiology out of South Carolina. In the continued arrangement, Zotec will provide ongoing coding, documentation training and revenue cycle management processes that optimize the group’s collections. Georgetown Radiology serves three outpatient imaging centers and two Georgetown, South Carolina hospitals: Tidelands Georgetown Memorial Hospital and Tidelands Waccamaw Community Hospital. If offers sophisticated imaging technology including Bone Density, Computed Tomography, Mammography, Magnetic Resonance Imaging, Nuclear Medicine, Ultrasound and Digital X-ray. Robert T. Whitehead III, MD, managing partner of Georgetown Radiology, says the group has seen positive results over a long-term relationship with Zotec. He notes, “For nearly three decades, we’ve depended on our revenue cycle management team for coding education and documentation knowledge that has helped us succeed.” Dr. Whitehead goes on to say that Zotec’s insights about the radiology industry, with updates to documentation changes, have been instrumental to the group’s success, stating, “Zotec constantly educates our group on changing radiology regulations that impact our business. Our radiologists rely on their support in this area, and they continue to give us guidance on the best ways to optimize our reimbursement.” Zotec’s Founder and CEO, T. Scott Law, agrees that Zotec works to ensure reports are correctly coded and documented, and that physicians are continually educated on both techniques to optimize their reimbursement. He says, “Our client services team is constantly monitoring the submission of claims for accuracy and minimized risk, and they alert Georgetown’s physicians of every claim issue in order to alleviate errors moving forward.” Mr. Law also points out that Zotec focuses on service first and foremost. “Our expert people work closely with practices to provide education, advice and information needed for correct documentation and ultimately, optimized reimbursement. This is one of the ways we are able to continue to delight our clients and make a difference,” he adds. Zotec is the largest radiology revenue cycle and practice management provider in the country, with more than 20 years in the radiology industry. Zotec integrates the best people, processes and technology for fast, accurate and compliant radiology reimbursement solutions. Zotec’s proprietary processes and technology manage in excess of 80 million medical encounters across all 50 states. Zotec Partners is the largest privately-held provider of healthcare revenue cycle management services in the United States. The company is committed to the continual pursuit of excellence in the physician revenue cycle management industry by delivering effective solutions through its proprietary technology, personalized service and measurable client results. Currently, Zotec serves more than 8,000 physicians in all 50 states. For media inquiries, contact Tara Rowland at trowland@zotecpartners.com. For more information about Zotec Partners, visit http://www.zotecpartners.com.


SAINT-GENIS-POUILLY, France, May 18, 2017 (GLOBE NEWSWIRE) -- Advanced Accelerator Applications S.A. (NASDAQ:AAAP) (AAA or the Company), an international specialist in Molecular Nuclear Medicine (MNM), today announced that it will receive a 2017 Industry Innovation Award from the National Organization for Rare Disorders (NORD®) for NETSPOT® (gallium Ga 68 dotatate), a diagnostic drug for the localization of neuroendocrine tumors (NETs) using a positron emission tomography (PET) scan, at the NORD Rare Impact Awards ceremony taking place in Washington, D.C. this evening. NORD is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them. Each year, NORD’s Rare Impact Awards program recognizes individuals and organizations that have made a positive impact on patients’ lives. NETs are a group of tumors originating in the neuroendocrine cells of many different organs. NETs can remain clinically silent for years, delaying the diagnosis in many patients. Symptomatology may also vary widely, further complicating accurate diagnosis of NETs. These cancers are rare, but due to their indolent nature and the generally long life expectancy of NET patients, they are the second most common type of gastrointestinal malignancy in the US, and their incidence is increasing.1,2 NETSPOT®, a first-in-class drug, was approved by the US Food and Drug Administration (FDA) in June 2016, 23 months after the pre-Investigational New Drug meeting with the Agency. NETSPOT® has been designated as an orphan drug by the FDA and European Medicines Agency. AAA and its radiopharmacy partners around the US have delivered approximately 1,200 doses of NETSPOT® to patients in the first quarter of 2017, and are currently delivering doses at a rate of approximately 800 per month. Stefano Buono, Chief Executive Officer of AAA stated, “We are honored to be recognized by NORD for the innovation NETSPOT® is bringing to the NET community. We believe NETSPOT® offers superior sensitivity and accuracy compared to previously available diagnostics for NET patients. In a clinical study, NETSPOT® demonstrated the ability to change patient management decisions in 71% of cases imaged with the previously available standard of care.3” In March 2016, NETSPOT® was included in the National Comprehensive Cancer Network® (NCCN) Clinical Practice Guidelines in Oncology update for the evaluation of NETs. In December 2016, the Centers for Medicare & Medicaid Services (CMS) granted NETSPOT® Transitional Pass-Through status under an “A-code” (A9587) for drug reimbursement, effective January 1, 2017. The same Healthcare Common Procedure Coding System (HCPCS) “A Code” may be used on claims to private payers. 1 Dasari A, et al. JAMA Oncol. 2017 2 Yao JC, et al. J Clin Oncol. 2008 3 Srirajaskanthan R, et al. J Nucl Med. 2010 NETSPOT® (gallium Ga 68 dotatate) is a radioactive diagnostic drug indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. There are no Contraindications for use. Warnings and Precautions include gallium Ga 68 dotatate contributing to a patient’s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. The safety of gallium Ga 68 dotatate was evaluated in three single center studies and in a survey of the scientific literature. No serious adverse reactions were identified. NETSPOT® is available in two forms: As a drug kit for reconstitution using a Ga 68 generator, and as a ready-to-use injection delivered from local radiopharmacies in select metropolitan areas. NETSPOT® has been designated as an orphan drug by the FDA and European Medicines Agency. For full prescribing information for NETSPOT® please refer to: http://go.usa.gov/cSywA. Advanced Accelerator Applications is an innovative radiopharmaceutical company that develops, produces and commercializes Molecular Nuclear Medicine products. AAA’s lead investigational therapeutic candidate, lutetium Lu 177 dotatate (Lutathera®), is a novel MNM compound that AAA is currently developing for the treatment of Neuroendocrine Tumors, a significant unmet medical need. Founded in 2002, AAA has its headquarters in Saint-Genis-Pouilly, France. AAA currently has 21 production and R&D facilities able to manufacture both diagnostics and therapeutic MNM products, and has more than 500 employees in 13 countries (France, Italy, the UK, Germany, Switzerland, Spain, Poland, Portugal, The Netherlands, Belgium, Israel, the US and Canada). AAA reported sales of €109.3 million in 2016 (+23% vs. 2015). AAA is listed on the Nasdaq Global Select Market under the ticker “AAAP”. For more information, please visit: www.adacap.com. This press release may contain forward-looking statements. All statements, other than statements of historical facts, contained in this press release, including statements regarding the Company's strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management, are forward-looking statements. The words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements reflect the Company's current expectation regarding future events. These forward-looking statements involve risks and uncertainties that may cause actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include, but are not limited to, changing market conditions, the successful and timely completion of clinical studies, the timing of our submission of applications for regulatory approvals, EMA, FDA and other regulatory approvals for our product candidates, the occurrence of side effects or serious adverse events caused by or associated with our products and product candidates; our ability to procure adequate quantities of necessary supplies and raw materials for lutetium Lu 177 dotatate (Lutathera®) and other chemical compounds acceptable for use in our manufacturing processes from our suppliers; our ability to organize timely and safe delivery of our products or product candidates by third parties; any problems with the manufacture, quality or performance of our products or product candidates; the rate and degree of market acceptance and the clinical utility of lutetium Lu 177 dotatate (Lutathera®) and our other products or product candidates; our estimates regarding the market opportunity for lutetium Lu 177 dotatate (Lutathera®), our other product candidates and our existing products; our anticipation that we will generate higher sales as we diversify our products; our ability to implement our growth strategy including expansion in the U.S.; our ability to sustain and create additional sales, marketing and distribution capabilities; our intellectual property and licensing position; legislation or regulation in countries where we sell our products that affect product pricing, taxation, reimbursement, access or distribution channels; regulatory actions or litigation; and general economic, political, demographic and business conditions in Europe, the U.S. and elsewhere. Except as required by applicable securities laws, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.


News Article | May 18, 2017
Site: www.eurekalert.org

Reston, Va. - The Society of Nuclear Medicine and Molecular Imaging's 2017 Annual Meeting will be held in Denver, Colorado, June 10-14. It will bring together more than 5,000 physicians, technologists, scientists and exhibitors from around the globe to share and learn about cutting-edge research, advance their knowledge through continuing education sessions, and network. The focus is on science--improving patients' lives by developing new methods to diagnose earlier and more accurately, delivering the most effective therapy for a specific patient's disease, and monitoring and adjusting treatment to ensure optimum results. There are series of sessions for scientists, physicians, and technologists covering latest advances in the field, including the growing role of nuclear medicine and molecular imaging in precision medicine. The Opening Plenary Session on Sunday, June 11, will feature theranostics. The Henry N. Wagner, Jr., MD, Lecture, titled "Theranostics: Looking Back and Moving Forward," will be given by Richard Baum, MD, PhD. Johannes Czernin, MD, editor-in-chief of The Journal of Nuclear Medicine will then speak on "Imaging with a Purpose: The Future of Nuclear Medicine, Molecular Imaging and Therapy." The Opening Plenary will also introduce the society's new Value Initiative, which addresses five critical domains that will guide the society's strategic plan over the next several years: Quality of Practice, Research and Development, Workforce Pipeline and Lifetime Education, Advocacy, and Outreach. SNMMI is an international organization that relies on collaboration across borders. This year, the annual meeting will highlight Germany's latest advances in research, technology, and clinical practice. The meeting will have more than 700 scientific oral sessions, as well as sessions on new tracers and applications, emerging technologies, a fluciclovine live reader training, updates on appropriate use criteria and coding and reimbursement, and Mo-99 production and availability. Three Meet-the-Author poster sessions will also be held, and the Exhibit Hall will be a one-stop showcase for cutting-edge molecular imaging devices, products, and services. The CT and MRI Case Reviews, presented in collaboration with the University of Colorado Denver, will provide 12 hours of review over two consecutive days and include 52 CT studies and 48 MRI case studies. In nuclear medicine and molecular imaging, the focus is always on the patient, and Patient Education Day, June 11, is an important part of the annual meeting. This year, it will include break-out sessions focusing on neuroendocrine tumors, prostate cancer, thyroid cancer, and Alzheimer's Disease. With many concurrent sessions, it's not possible to attend everything of interest in person. The Virtual Poster Hall and Virtual Meeting will be available after the meeting for further education. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to raising public awareness about nuclear medicine and molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated and helping provide patients with the best health care possible. SNMMI's more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www. .


SAINT-GENIS-POUILLY, France, May 18, 2017 (GLOBE NEWSWIRE) -- Advanced Accelerator Applications S.A. (NASDAQ:AAAP) (AAA or the Company), an international specialist in Molecular Nuclear Medicine (MNM), today announced that it will receive a 2017 Industry Innovation Award from the National Organization for Rare Disorders (NORD®) for NETSPOT® (gallium Ga 68 dotatate), a diagnostic drug for the localization of neuroendocrine tumors (NETs) using a positron emission tomography (PET) scan, at the NORD Rare Impact Awards ceremony taking place in Washington, D.C. this evening. NORD is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them. Each year, NORD’s Rare Impact Awards program recognizes individuals and organizations that have made a positive impact on patients’ lives. NETs are a group of tumors originating in the neuroendocrine cells of many different organs. NETs can remain clinically silent for years, delaying the diagnosis in many patients. Symptomatology may also vary widely, further complicating accurate diagnosis of NETs. These cancers are rare, but due to their indolent nature and the generally long life expectancy of NET patients, they are the second most common type of gastrointestinal malignancy in the US, and their incidence is increasing.1,2 NETSPOT®, a first-in-class drug, was approved by the US Food and Drug Administration (FDA) in June 2016, 23 months after the pre-Investigational New Drug meeting with the Agency. NETSPOT® has been designated as an orphan drug by the FDA and European Medicines Agency. AAA and its radiopharmacy partners around the US have delivered approximately 1,200 doses of NETSPOT® to patients in the first quarter of 2017, and are currently delivering doses at a rate of approximately 800 per month. Stefano Buono, Chief Executive Officer of AAA stated, “We are honored to be recognized by NORD for the innovation NETSPOT® is bringing to the NET community. We believe NETSPOT® offers superior sensitivity and accuracy compared to previously available diagnostics for NET patients. In a clinical study, NETSPOT® demonstrated the ability to change patient management decisions in 71% of cases imaged with the previously available standard of care.3” In March 2016, NETSPOT® was included in the National Comprehensive Cancer Network® (NCCN) Clinical Practice Guidelines in Oncology update for the evaluation of NETs. In December 2016, the Centers for Medicare & Medicaid Services (CMS) granted NETSPOT® Transitional Pass-Through status under an “A-code” (A9587) for drug reimbursement, effective January 1, 2017. The same Healthcare Common Procedure Coding System (HCPCS) “A Code” may be used on claims to private payers. 1 Dasari A, et al. JAMA Oncol. 2017 2 Yao JC, et al. J Clin Oncol. 2008 3 Srirajaskanthan R, et al. J Nucl Med. 2010 NETSPOT® (gallium Ga 68 dotatate) is a radioactive diagnostic drug indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. There are no Contraindications for use. Warnings and Precautions include gallium Ga 68 dotatate contributing to a patient’s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. The safety of gallium Ga 68 dotatate was evaluated in three single center studies and in a survey of the scientific literature. No serious adverse reactions were identified. NETSPOT® is available in two forms: As a drug kit for reconstitution using a Ga 68 generator, and as a ready-to-use injection delivered from local radiopharmacies in select metropolitan areas. NETSPOT® has been designated as an orphan drug by the FDA and European Medicines Agency. For full prescribing information for NETSPOT® please refer to: http://go.usa.gov/cSywA. Advanced Accelerator Applications is an innovative radiopharmaceutical company that develops, produces and commercializes Molecular Nuclear Medicine products. AAA’s lead investigational therapeutic candidate, lutetium Lu 177 dotatate (Lutathera®), is a novel MNM compound that AAA is currently developing for the treatment of Neuroendocrine Tumors, a significant unmet medical need. Founded in 2002, AAA has its headquarters in Saint-Genis-Pouilly, France. AAA currently has 21 production and R&D facilities able to manufacture both diagnostics and therapeutic MNM products, and has more than 500 employees in 13 countries (France, Italy, the UK, Germany, Switzerland, Spain, Poland, Portugal, The Netherlands, Belgium, Israel, the US and Canada). AAA reported sales of €109.3 million in 2016 (+23% vs. 2015). AAA is listed on the Nasdaq Global Select Market under the ticker “AAAP”. For more information, please visit: www.adacap.com. This press release may contain forward-looking statements. All statements, other than statements of historical facts, contained in this press release, including statements regarding the Company's strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management, are forward-looking statements. The words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements reflect the Company's current expectation regarding future events. These forward-looking statements involve risks and uncertainties that may cause actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include, but are not limited to, changing market conditions, the successful and timely completion of clinical studies, the timing of our submission of applications for regulatory approvals, EMA, FDA and other regulatory approvals for our product candidates, the occurrence of side effects or serious adverse events caused by or associated with our products and product candidates; our ability to procure adequate quantities of necessary supplies and raw materials for lutetium Lu 177 dotatate (Lutathera®) and other chemical compounds acceptable for use in our manufacturing processes from our suppliers; our ability to organize timely and safe delivery of our products or product candidates by third parties; any problems with the manufacture, quality or performance of our products or product candidates; the rate and degree of market acceptance and the clinical utility of lutetium Lu 177 dotatate (Lutathera®) and our other products or product candidates; our estimates regarding the market opportunity for lutetium Lu 177 dotatate (Lutathera®), our other product candidates and our existing products; our anticipation that we will generate higher sales as we diversify our products; our ability to implement our growth strategy including expansion in the U.S.; our ability to sustain and create additional sales, marketing and distribution capabilities; our intellectual property and licensing position; legislation or regulation in countries where we sell our products that affect product pricing, taxation, reimbursement, access or distribution channels; regulatory actions or litigation; and general economic, political, demographic and business conditions in Europe, the U.S. and elsewhere. Except as required by applicable securities laws, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.


News Article | May 16, 2017
Site: www.prnewswire.com

Professor Genese Gibson, formerly the Chair of Radiologic Sciences, has been appointed as the new department's Chair. This September will be Professor Gibson's 30th year with Florida Hospital and Adventist Health System, and she has been with ADU since its inception in 1992. She helped pioneer online learning on the campus, playing an important role in launching the University's first online course. When ADU opened its satellite campus in Denver, Dr. David Greenlaw, ADU's President, chose her program to lead out the expansion. A few other faculty members have stepped into new roles as part of this new transition. Professor Charlotte Henningsen, formerly the Department Chair of Sonography, now holds dual roles as Associate Vice President for Faculty Development in Teaching & Learning and Director of the Center for Advanced Ultrasound Education. Professor Deziree Rada is the new Program Director of Sonography and Professor Kelly Mumbert has been appointed as Online Coordinator for the Sonography Department. Adventist University of Health Sciences (ADU) is a Seventh-day Adventist institution specializing in healthcare education in a faith-affirming environment. Service-oriented and guided by the values of nurture, excellence, spirituality, and stewardship, the University seeks to develop leaders who will practice healthcare as a ministry. ADU fulfills this mission by developing skilled professionals who live the healing values of Christ. ADU offers undergraduate and graduate programs including:  Biomedical Sciences, Diagnostic Medical Sonography, Health Sciences, Radiography, Nuclear Medicine Technology, Nursing (BSN), Nurse Anesthesia, Occupational Therapy, Healthcare Administration, Physician Assistant, and Physical Therapy. The University is associated with Florida Hospital and the Adventist Health System. ADU embraces the benefit of whole person care as demonstrated in the life and ministry of Christ. The University is dedicated to developing skilled professionals who live the healing values of Christ. Graduates who live these values effectively extend the healing ministry of Christ. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/increased-educational-support-with-adus-new-imaging-department-300458528.html


The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. This report analyzes the worldwide markets for Nuclear Medicine Imaging Equipment in US$ Thousand by the following Product Segments: Further, the Global market for PET Systems is analyzed by the following: The report profiles 30 companies including many key and niche players such as For more information about this report visit http://www.researchandmarkets.com/research/r376t6/nuclear_medicine To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/research-and-markets---global-nuclear-medicine-imaging-equipment-market-2015-2022profiles-of-leading-players-including-digirad-ge-healthcare-mediso-medical-imaging-systems-philips-healthcare-positron-and-siemens-300444929.html


Dublin, April 25, 2017 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Nuclear Medicine Imaging Equipment - Global Strategic Business Report" report to their offering. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. This report analyzes the worldwide markets for Nuclear Medicine Imaging Equipment in US$ Thousand by the following Product Segments: Further, the Global market for PET Systems is analyzed by the following: The report profiles 30 companies including many key and niche players such as 8. GLOBAL MARKET PERSPECTIVE For more information about this report visit http://www.researchandmarkets.com/research/mk95p5/nuclear_medicine


Feyer P.,Nuclear Medicine | Jordan K.,Martin Luther University of Halle Wittenberg
Annals of Oncology | Year: 2011

Chemotherapy-induced nausea and vomiting (CINV) continues to be one of the most feared side effects of chemotherapy. Inadequately controlled CINV can have a significant negative impact on quality of life and can in some cases compromise adherence to treatment. However, the repercussions of CINV for patients are often underestimated. Advances in our understanding of the physiology of CINV and the identification of risk factors have greatly contributed towards improvements in the control of CINV. A number of antiemetic agents are currently available for the prophylaxis and treatment of CINV, including 5-hydroxytryptamine 3 receptor antagonists corticosteroids, neurokinin 1 receptor antagonists, dopamine receptor antagonists, benzodiazepines, neuroleptics and cannabinoids. With the correct use of these agents, CINV can be prevented to a great extent; however, adherence to guidelines is disappointingly low. Furthermore, a significant number of patients still experience nausea and vomiting despite optimal treatment. More effective therapies are, therefore, greatly needed, with the ultimate goal of attaining complete control of CINV. This review focuses on the current understanding of CINV, problems associated with its management and the status of promising antiemetic therapies. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

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