NU eco Engineering Co.

Miyoshi, Japan

NU eco Engineering Co.

Miyoshi, Japan
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Iseki S.,Nagoya University | Ohta T.,Wakayama University | Aomatsu A.,Wakayama University | Ito M.,Meijo University | And 3 more authors.
Applied Physics Letters | Year: 2010

A promising, environmentally safe method for inactivating fungal spores of Penicillium digitatum, a difficult-to-inactivate food spoilage microorganism, was developed using a high-density nonequilibrium atmospheric pressure plasma (NEAPP). The NEAPP employing Ar gas had a high electron density on the order of 1015 cm-3. The spores were successfully and rapidly inactivated using the NEAPP, with a decimal reduction time in spores (D value) of 1.7 min. The contributions of ozone and UV radiation on the inactivation of the spores were evaluated and concluded to be not dominant, which was fundamentally different from the conventional sterilizations. © 2010 American Institute of Physics.


Patent
Nagoya University, NU Eco Engineering Co. and Katagiri Engineering Co. | Date: 2013-07-03

[Object] To provide a radical generator which can produce radicals at higher density. [Means for Solution] The radical generator includes a supply tube 10 made of SUS, a hollow cylindrical plasma-generating tube 11 which is connected to the supply tube 10 and which is made of pyrolytic boron nitride (PBN). A cylindrical CCP electrode 13 is disposed outside the plasma-generating tube 11. A coil 12 is provided so as to wind about the outer circumference of the plasma-generating tube at the downstream end of the CCP electrode 13. A parasitic-plasma-preventing tube 15 made of a ceramic material is inserted into an opening of the supply tube 10 at the connection site between the supply tube 10 and the plasma-generating tube 11.


Patent
Nagoya University, NU ECO Engineering Co. and Katagiri Engineering Co. | Date: 2016-08-19

A molecular beam epitaxy apparatus includes a radical generator for generating a radical species, a molecular beam cell for generating a molecular beam or an atomic beam, and a vacuum chamber for accommodating a substrate therein, in use, the substrate being irradiated with the radical species and the molecular beam or the atomic beam in vacuum, to thereby form, on the substrate, a crystal of a compound derived from the element of the radical species and the element of the molecular beam or the atomic beam.


Patent
KATAGIRI Engineering Co and NU Eco Engineering Co. | Date: 2011-08-24

[Object] To provide a radical generator which can produce radicals at higher density. [Means for Solution] The radical generator includes a supply tube 10 made of SUS, a hollow cylindrical plasma-generating tube 11 which is connected to the supply tube 10 and which is made of pyrolytic boron nitride (PBN). A cylindrical CCP electrode 13 is disposed outside the plasma-generating tube 11. A coil 12 is provided so as to wind about the outer circumference of the plasma-generating tube at the downstream end of the CCP electrode 13. A parasitic-plasma-preventing tube 15 made of a ceramic material is inserted into an opening of the supply tube 10 at the connection site between the supply tube 10 and the plasma-generating tube 11.


Mase K.,Nagoya University | Kondo H.,Nagoya University | Kondo S.,Nagoya University | Hori M.,Nagoya University | And 2 more authors.
Applied Physics Letters | Year: 2011

An ultrahigh density over 1013 cm-2 of 2 nm diameter Pt nanoparticles was obtained by metal-organic chemical supercritical fluid deposition over the entire surface of vertically standing stacked graphene sheets (carbon nanowalls) on a substrate. The correlation between the surface defect density of graphene sheets and the density of Pt nanoparticles were investigated to clarify the support mechanism. The density of Pt nanoparticles increased with increase in the surface defect density. In addition, the semispherical cross-sectional shape of the nanoparticles indicated nucleation at the surface defects on the graphene sheets (98/100). © 2011 American Institute of Physics.


Iseki S.,Nagoya University | Nakamura K.,Nagoya University | Hayashi M.,Nagoya University | Tanaka H.,Nagoya University | And 5 more authors.
Applied Physics Letters | Year: 2012

Two independent ovarian cancer cell lines and fibroblast controls were treated with nonequilibrium atmospheric pressure plasma (NEAPP). Most ovarian cancer cells were detached from the culture dish by continuous plasma treatment to a single spot on the dish. Next, the plasma source was applied over the whole dish using a robot arm. In vitro cell proliferation assays showed that plasma treatments significantly decreased proliferation rates of ovarian cancer cells compared to fibroblast cells. Flow cytometry and western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis. NEAPP could be a promising tool for therapy for ovarian cancers. © 2012 American Institute of Physics.


Utsumi F.,Nagoya University | Kajiyama H.,Nagoya University | Nakamura K.,Nagoya University | Tanaka H.,Nagoya University | And 6 more authors.
PLoS ONE | Year: 2013

Purpose: Nonequilibrium atmospheric pressure plasma (NEAPP) therapy has recently been focused on as a novel medical practice. Using cells with acquired paclitaxel/cisplatin resistance, we elucidated effects of indirect NEAPP-activated medium (NEAPP-AM) exposure on cell viability and tumor growth in vitro and in vivo. Methods: Using chronic paclitaxel/cisplatin-resistant ovarian cancer cells, we applied indirect NEAPP-exposed medium to cells and xenografted tumors in a mouse model. Furthermore, we examined the role of reactive oxygen species (ROS) or their scavengers in the above-mentioned EOC cells. Results: We assessed the viability of NOS2 and NOS3 cells exposed to NEAPP-AM, which was prepared beforehand by irradiation with NEAPP for the indicated time. In NOS2 cells, viability decreased by approximately 30% after NEAPP-AM 120-sec treatment (P<0.01). The growth-inhibitory effects of NEAPP-AM were completely inhibited by N-acetyl cysteine treatment, while L-buthionine-[S, R]-sulfoximine, an inhibitor of the ROS scavenger used with NEAPP-AM, decreased cell viability by 85% after NEAPP-AM 60-sec treatment(P<0.05) and by 52% after 120 sec, compared to the control (P<0.01). In the murine subcutaneous tumor-formation model, NEAPP-AM injection resulted in an average inhibition of the NOS2 cell-inoculated tumor by 66% (P<0.05) and NOS2TR cell-inoculated tumor by 52% (P<0.05), as compared with the control. Conclusion: We demonstrated that plasma-activated medium also had an anti-tumor effect on chemo-resistant cells in vitro and in vivo. Indirect plasma therapy is a promising treatment option for EOC and may contribute to a better patient prognosis in the future. © 2013 Utsumi et al.


Patent
NU Eco Engineering Co. | Date: 2010-10-21

A spectroscopy method, includes guiding pulse laser light to an optical fiber, which mutually reacts with a sample to be measured of a light absorptance characteristic, outputting ring down pulse light obtained through light absorption of the sample, measuring an absorptance characteristic of the sample based on an attenuation characteristic of the ring down pulse light, and setting the pulse laser light as wide-spectrum laser light, setting the optical fiber as a strong dispersive optical fiber, and increasing a pulse width of the ring down pulse light to measure a wavelength absorptance characteristic based on a ring down attenuation constant of a pulse train with respect to a time sequence corresponding to a wavelength.


Patent
NU Eco Engineering Co. | Date: 2010-12-01

To provide a plasma generator having a plasma-generating zone of an increased volume. A plasma generator 100 has a casing 10 made of a sintered ceramic produced from alumina (Al_(2)O_(3)) as a raw material. The casing 10 has a slit-like gas intake section 12, and a gas discharge section 20 in which a plurality of holes are disposed in a line. From the gas intake section 12 to the top of a plasma-generating zone P, the slits have a width of 1 mm. There is provided a second gas discharge section 22 including holes 24 which have a diameter of 0.5 mm and a length of 16 mm and which are arranged in a line along the longitudinal axis of the plasma -generating zone P. The plasma-generating zone P has a cross-section which is a rectangle having a side of 2 to 5 mm. Electrodes 2a, 2b are provided with hollow portions on the surfaces thereof facing each other. A power sources supplies about 9 kV, which is obtained by boosting 100 V (60 Hz) and is applied to the electrodes 2a, 2b with a current of 20 mA. When argon gas is supplied through a gas intake section 18, a plasma was generated, even when the electrodes 2a, 2b were separated at a maximum spacing of 4 cm. No electric discharge was generated between the tips of the holes 24 and a treatment object.


Patent
NU Eco Engineering Co. | Date: 2010-03-12

According to the present invention, a long electric discharge path is formed, and a workpiece is irradiated with an atmospheric plasma of a long rectangular area. An argon flow at a first gas outlet forms argon plasma by high-frequency electric power between the first and second electrodes, and the plasma is jetted as an auxiliary plasma in the longitudinal direction from the left end of a primary plasma-generating zone. Another argon flow at a second gas outlet forms argon plasma by high-frequency electric power between the third and fourth electrodes, and the plasma is jetted as an auxiliary plasma in the longitudinal direction from the right end of the primary plasma-generating zone. When high-frequency electric power is applied to the first and third electrodes, electric discharge occurs between two argon plasmas flowing from both ends of the primary plasma-generating zone. Through the electric discharge, the discharge state is maintained in the entire primary plasma-generating zone. Then, oxygen and argon are supplied through gas mixture (argon and oxygen)-supplying pipes to the plasma-generating zone, oxygen plasma is generated. The oxygen plasma is jetted through 170 second holes disposed at the bottom side wall of the cylindrical section to the outside in a direction normal to the side wall, whereby a workpiece is irradiated with oxygen plasma in a long belt-like area having a length of 50 cm.

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