Bellocchio L.,NSERM U862 |
Bellocchio L.,University of Bordeaux 1 |
Lafentre P.,NSERM U862 |
Lafentre P.,University of Bordeaux 1 |
And 12 more authors.
Nature Neuroscience | Year: 2010
Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB 1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids. © 2010 Nature America, Inc. All rights reserved.