NRI Institute of Pharmaceutical science

Bhopal, India

NRI Institute of Pharmaceutical science

Bhopal, India
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Darveshwar Jagdeep D.,NRI Institute of Pharmaceutical Science
Asian Journal of Pharmaceutical Research and Health Care | Year: 2012

The present study was aimed towards development and evaluation of tablet as a floating-Mucoadhesive drug delivery system, which can provide sustained release of the model drug. The work also was aimed to study various parameters affecting the behavior of floating-mucoadhesive tablet in oral dosage form. Formulation of Gastro-Retentive Dosage Forms (GRDFs) containing suitable drug candidate which would remain in stomach and/or upper part of GIT for prolonged period of time thereby is maximizing the drug release at desired site within the time before GRDFs leave the stomach and or upper part of GIT. Dipyridamole is BCS class II drug having low solubility and high permeability. It is soluble at low pH but insoluble in high pH (i.e. alkaline ph of small intestine)its oral bioavailability is 37-66% & biological half life is also short (40 min). In this study the bioavailability of the dipyridamole increase by using various concentration of HPMC, Carbapol and Sodium bicarbonate for swelling, mucoadhesive and floating behavior respectively. Bioadhesive strength depends upon carbapol as concentration of polymer increases bioadhesive strength also increases. HPMC is water Swealable but Carbapol is hydrogel in nature it restricts movement of polymer and affect the swelling index.


Malik J.K.,P.A. College | Sharma A.,P.A. College | Singh S.,P.A. College | Jain S.,NRI Institute of Pharmaceutical science
Drug Invention Today | Year: 2013

Objective: Vasicine the major alkaloid found in Adhatoda vasica shows better potent bronchodilation response compared to theophylline, despite extensive research, this compound not yet been approved or used as a single therapeutic molecule. The major problem associated with vasicine is its low bioavailability and stability hence no single formulation of vasicine alone is available in market. Method: The present study on isolation of vasicine from A. vasica and characterize by various phytochemical test the isolated vasicine is an attempt foris better formulation which may be useful as a novel drug delivery system. In the present study, vasicine nanosuspension was prepared by the solvent/anti-solvent method and stabilized by a surface active agent. Result & discussion: The average particle size of the obtained nanoparticles, as estimated by field emission scanning electron microscope (FESEM) micrographs, is observed to be about 60-80nm and the particle had spherical morphology. Particle size analysis results shows that about 50% of particle in nanosuspension were found to be in the range of 8-10nm and while the other half is in the range of 210-230nm. The average particle size distribution is found to be ~115nm and zeta potential is -6.91mV. © 2013 JPR Solutions. Published by Reed Elsevier India Pvt. Ltd.


Rathi J.C.,NRI Institute of Pharmaceutical science
Indian Drugs | Year: 2016

The objective of the present investigation is to attain optimized floating drug delivery system for aceclofenac by determining the effects of some important factors for the prolongation of gastric residence time. Floating microspheres were prepared by solvent diffusion-evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A central composite design was applied to optimize the formulation. An appropriate balance between the levels of the polymer and stirring speed was imperative to acquire maximum drug entrapment efficiency, sustained release of the drug, floating ability and adequate particle size.


Milind P.,NRI Institute of Pharmaceutical science | Anupam P.,Barkatullah University
Journal of Global Pharma Technology | Year: 2010

Homeopathic formulations do not have much more of standardization in our country. Even the pharmacopoeial standards for mother tinctures are far from complete. The objective of this work was to provide some additional parameters to test the mother tincture so as to determine the identity and quality. For this purpose the mother tincture of leaves of Chenopodium album Linn (Chinopodiaceae) was selected as a model tincture and investigated for the following parameters. Viz. organoleptic properties, physical properties, and chemical properties, HPTLC finger printing studies and quantification of active constituents. © 2009, JGPT.


Pande M.,NRI Institute of Pharmaceutical science | Pathak A.,Barkatullah University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

The roots of Mimosa pudica Linn (Mimosae) are reported to have great medicinal value. Pharmacognostic evaluation including examinations of morphological and microscopic characters, ash value, powder analysis, and extractive values were carried out. Phytochemical screening including qualitative chemical examinations was also carried out.


Singh H.,NRI Institute of Pharmaceutical science | Mishra S.K.,NRI Institute of Pharmaceutical science | Pande M.,NRI Institute of Pharmaceutical science
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

Ayurveda is the oldest surviving complete medical system in the world. Its origins go back nearly 5000 years. Arjunarishta (Parthadyarishta) is an important Ayurvedic formulation used for cardiovascular disorders and is prepared by fermenting the decoction of specified plant materials using flowers of Woodfordia fruticosa. The objective of this study was to determine the level of alcohol, acidity and pH in commercially available Arjunarishth to establish a routine procedure for standardization of these Ayurvedic preparations. In present communication, a TLC- method was developed for the standardization of Arjunarishta by quantitative estimation of major antioxidant compounds, ellagic acid, as markers. The developed method was validated with respect to linearity, precision, accuracy, and robustness. Arjunolic acid and arjunic acid were not detected in the formulation.


Parihar S.S.,NRI Institute of Pharmaceutical science | Ku Mishra S.,NRI Institute of Pharmaceutical science | Singh H.,NRI Institute of Pharmaceutical science | Ambrish R.,NRI Institute of Pharmaceutical science
International Journal of PharmTech Research | Year: 2010

Ashokarista is ayurvedic herbal remedy with autogenous fermented alcohol with Ashoka (Saraca indica) as the chief ingredient used for Rejuvenates female reproductive organs & blood. And is prepared by fermenting the decoction of specified plant materials using flowers of Woodfordia fruticosa, Cuminum cyminum, Nigella sativa and Cyperus rotundus. In present communication, a TLC method was developed for the standardization of Ashokarista by quantitative estimation of major compounds, catachin, (+) catechole, (-) epicatechin. Antibacterial Activity of Cuminum cyminum L. Essential Oils as markers. The developed method was validated with respect to linearity, precision, accuracy, and robustness.


Siddique S.,Jadavpur University | Bose A.,NRI Institute of Pharmaceutical science | Khanam J.,Jadavpur University
Drug Development and Industrial Pharmacy | Year: 2011

The objective of this study was to develop sustained release (SR) matrix tablets of metoprolol succinate (MS), by using different polymer combinations and fillers, to optimize by response surface methodology and to evaluate biopharmaceutical parameters of the optimized product. Matrix tablets of various combinations were prepared with cellulose-based polymers: hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC); and lactose and dibasic calcium phosphate dihydrate (DCP) as fillers. Study of pre-compression and post-compression parameters facilitated the screening of a formulation with best characteristics that underwent here optimization study by response surface methodology (Central Composite Design). The optimized tablet was subjected to further study like scanning electron microscopy, swelling study and in vivo study in rabbit model. Both in vitro and in vivo study revealed that combining of HPMC K100M (21.95%) with EC (8.85%), and use of DCP as filler sustained the action up to 12 h. The in vivo study of new SR tablets showed significant improvement in the oral bioavailability of MS in rabbits after a single oral dose of 25 mg. The delayed T max and lower C max indicated a slow and SR of MS from the optimized matrix tablets in comparison with the immediate release dosage form. The developed SR (MS) tablet of improved efficacy can perform therapeutically better than conventional tablet. © 2011 Informa Healthcare USA, Inc.


Mehrotra A.,NRI Institute of Pharmaceutical science | Nagarwal R.C.,Banaras Hindu University | Pandit J.K.,Banaras Hindu University
Chemical and Pharmaceutical Bulletin | Year: 2011

The aim of this work was to prepare chitosan nanoparticles loaded with antineoplastic drug Lomustine (LCNPs), by ionic-gelation method with homogenization. The nanoparticles were characterized for particle size, polydispersity index (PDI), surface morphology, encapsulation efficiency, in-vitro drug release and cytotoxicity on human lung cancer cell line L132 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The particle size, zeta potential and encapsulation efficiency of prepared nanoparticles ranged from 75±1.1 to 637±1.6 nm (PDI from 0.05±0.001 to 0.18±0.007), 37.2±0.21 to 53.8±0.18 mV and 66.74±1.4 to 98.0±1.8% respectively. The particles were spherical in shape with smooth surface in scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. Mechanical shearing by homogenization treatment significantly changed the nanoparticle size. The drug release rate was biphasic and diffusion controlled over the 8 h. LCNPs greatly inhibited the growth of the L132 cancer cell line used in this study in comparison to the native Lomustine (LMT). © 2011 Pharmaceutical Society of Japan.


Singh H.,NRI Institute of Pharmaceutical science | Mishra S.K.,NRI Institute of Pharmaceutical science | Varma R.,NRI Institute of Pharmaceutical science | Parihar S.S.,NRI Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2011

The aim of the present research work was to enhance the solubility of Carvedilol by solid dispersion method and to formulate a mouth dissolving tablet. Drugs are more frequently taken by oral administration. The solubility of Carvedilol enhanced with different ratios of PVP by the solvent evaporation method. In-vitro release profile of solid dispersion obtained in SGF with out enzymes and Ph 6.8 phosphate buffer indicate that 100% drug release found within 20 min. These solid dispersion were directly compressed into tablets using crospovidone, sodium starch glycol ate, croscarmellose sodium and polacrilin potassium in different concentrations as a superdisintgrants. The prepared tablets containing the solid dispersion of Carvedilol having sufficient strength of 2.5-4 kg/cm 2. The disintegranted in the oral cavity with in 21 sec. contain crospovidone (5%) as super disintegrant.

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