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Khurja, India

Saxena A.,Swami Keshvanand Institute of Technology | Upadhyay R.,NREC College
Oriental Journal of Chemistry | Year: 2012

Mixed ligand complexes of zinc (II) involving either mercaptyl thiazolidinone (1) [2-(2-hydroxy benzoyl)-3-N-(2-mercaptyl)-1-Thiazolidin-4-one] or pyridine thiazolidinone (2) [ 2-(2-hydroxy benzoyl-3-N-(2-Pyridinyl)-1- Thiazolidin-4-one] alone and along with thiourea have been obtained by partial or complete replacement of the strongly coordinated ammonia of ammine complex. All the products have been characterized by elemental analysis, molar conductance, magnetic susceptibility and IR and electronic spectral measurements for their bonding and structures. Source


Singh V.,University of Delhi | Kaushik N.K.,NREC College
Oriental Journal of Chemistry | Year: 2011

The microwave-enhanced synthesis of sulphaguanidine is achieved rapidly and in good yield via the step-wise reaction of cyanamide with sulphonamide in the presence of acidic alumina or montmorillonite clays (KSF and K10). Source


Mohapatra S.C.,University of Delhi | Tiwari H.K.,NREC College | Singla M.,University of Delhi | Rathi B.,University of Delhi | And 5 more authors.
Journal of Biological Inorganic Chemistry | Year: 2010

A new class of copper(II) nanohybrid solids, LCu(CH3COO) 2 and LCuCl2, have been synthesized and characterized by transmission electron microscopy, dynamic light scattering, and IR spectroscopy, and have been found to be capped by a bis(benzimidazole) diamide ligand (L). The particle sizes of these nanohybrid solids were found to be in the ranges 5-10 and 60-70 nm, respectively. These nanohybrid solids were evaluated for their in vitro antimalarial activity against a chloroquine-sensitive isolate of Plasmodium falciparum (MRC 2). The interactions between these nanohybrid solids and plasmepsin II (an aspartic protease and a plausible novel target for antimalarial drug development), which is believed to be essential for hemoglobin degradation by the parasite, have been assayed by UV-vis spectroscopy and inhibition kinetics using Lineweaver-Burk plots. Our results suggest that these two compounds have antimalarial activities, and the IC50 values (0.025-0.032 μg/ml) are similar to the IC50 value of the standard drug chloroquine used in the bioassay. Lineweaver-Burk plots for inhibition of plasmepsin II by LCu(CH3COO)2 and LCuCl2 show that the inhibition is competitive with respect to the substrate. The inhibition constants of LCu(CH3COO)2 and LCuCl2 were found to be 10 and 13 μM, respectively. The IC50 values for inhibition of plasmepsin II by LCu(CH3COO)2 and LCuCl 2 were found to be 14 and 17 μM, respectively. Copper(II) metal capped by a benzimidazole group, which resembles the histidine group of copper proteins (galactose oxidase, β-hydroxylase), could provide a suitable anchoring site on the nanosurface and thus could be useful for inhibition of target enzymes via binding to the S1/S3 pocket of the enzyme hydrophobically. Both copper(II) nanohybrid solids were found to be nontoxic against human hepatocellular carcinoma cells and were highly selective for plasmepsin II versus human cathepsin D. The pivotal mechanism of antimalarial activity of these compounds via plasmepsin II inhibition in the P. falciparum malaria parasite is demonstrated. © 2009 SBIC. Source


Saxena A.,Swami Keshvanand Institute of Technology | Upadhyay R.,NREC College
Oriental Journal of Chemistry | Year: 2014

Mixed ligand complexes of copper (II), involving either Mercaptyl thiazolidinone (1) [2-(2-hydroxy benzoyl)-3-N-(2-mercaptyl)-1-Thiazolidin-4-one] or Pyridine thiazolidinone (2) [2-(2-hydroxy benzoyl-3-N-(2-Pyridinyl)-1-Thiazolidin-4-one] alone and along with Thiourea were synthesized by partial or complete replacement of the strongly coordinated ammonia of ammine complex. All the products have been characterized by elemental analysis, molar conductance, magnetic susceptibility, IR and electronic spectral measurements for their bonding and structures. © Oriental Scientific Publishing Company. All rights reserved. Source


Kumar R.,Bareilly College | Bharati K.A.,NREC College
Indian Journal of Natural Products and Resources | Year: 2012

This study aims to document folk medicinal knowledge of plants used for the treatment of livestock in the Sitapur district of Uttar Pradesh. Information on these veterinary practices was gathered from June 2009 to April 2010 by interviewing residents using the "Transect walks" method of the Participatory Rural Appraisal (PRA) technique. The method was based on semi-structured interviews and discussions with key research participants. A total of fifty-seven medicinal formulas were recorded for use in the treatment of different livestock diseases. These formulations are not reported in earlier published literature. Source

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