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Girard V.,Novasep Belgium | Hilbold N.-J.,Novasep Process SAS | Ng C.K.S.,Circle Inc. | Pegon L.,Novasep Process SAS | And 3 more authors.
Journal of Biotechnology | Year: 2015

The development and optimization of a purification process of monoclonal antibodies based on two continuous chromatography steps for capture and intermediate purification are presented. The two chromatography steps were individually optimized using either batch chromatography or sequential multicolumn chromatography (SMCC). Proprietary simulation software was used to optimize SMCC and to evaluate the potential gains compared with batch chromatography. The SMCC recipes provided by the simulation software were evaluated experimentally. A good correlation was found between the simulated results and experimental observations. Significant gains were observed on the productivity, buffer consumption and the volume of resin required for SMCC over batch chromatography. Based on these results, a chained process from the capture to polishing steps was implemented. This chained process demonstrated significantly better performance compared with the batch equivalent while satisfying the specifications. The expected positive impact provided by implementing continuous chromatography is also discussed. © 2015 Elsevier B.V.


Ruland Y.,NOVASEP ASIA Co. | Colin H.,ULYSSE CONSULT | David L.,NOVASEP PROCESS SAS
Russian Journal of Biopharmaceuticals | Year: 2011

Preparative chromatography processes already implemented at large scale or considered as a first choice technology for the near future are discussed. Bulk antibiotics, amino acids, peptides and proteins, sugars and oligosaccharides, chiral and non chiral API's are the products taken as application examples.


In the present world economics, the prices of sugar are significantly influenced by large cane sugar producers/exporters like Brazil, and sustainable domestic sugar production in other cane producing countries. In comparison, cereals whose prices have been very volatile since 2008, are now considered a more questionable raw material for the production of liquid sugars such as high fructose syrups. The production of liquid sugars (sucrose or medium invert) at the Cane Sugar Refinery is now gaining new recognition for several reasons: (i) the raw material is available in large quantities at competitive prices, (ii) because of the proximity of the Sugar Refinery to the Food Industry there is the possibility to build large-scale efficient central units for liquid sugars, and (iii) energy usage can be saved by avoiding the costs of crystallization, when supplying directly a liquid product ready to use. This book chapter describes various production systems, starting from different types of raw material and using a combination of purification technologies, to produce high quality liquid sugars suitable for the market. Copyright. © 2010 American Chemical Society.


Patent
Novasep Process Sas | Date: 2014-10-22

A method for purification of a first polyunsaturated fatty acid from an initial mixture is provided where the initial mixture comprises at least one second fatty acid in addition to the first polyunsaturated fatty acid. The method may comprise: The disclosure also provides a system suitably adapted for the implementation of this method.

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