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Pompey, France

Rabiller-Baudry M.,French National Center for Scientific Research | Nasser G.,French National Center for Scientific Research | Delaunay D.,French National Center for Scientific Research | Keraani A.,French National Center for Scientific Research | And 6 more authors.
WIT Transactions on Ecology and the Environment | Year: 2011

The development of chemical reactions catalysed by homogeneous organometallic complexes has allowed a significant breakthrough in synthesis chemistry, but now research axes must integrate catalysts recycling at the early stage of their conception. Catalyst recycling by nanofiltration in organic solvent (OSN) may represent an innovative route since this separation process at a molecular level is a low energy consumer. Challenges for OSN are membrane stability in organic solvents and the mastering of filtration conditions. Molecular engineering of catalysts based on slight structural modifications is also proposed to associate activity and high retention for OSN recycling. This paper deals with the integration of OSN within the homogeneous catalytic olefin metathesis reaction. © 2012 WIT Press. Source


Trademark
Novasep Process and Novasep | Date: 2006-10-17

LABORATORY APPARATUS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, COLUMNS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY; EVAPORATORS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY; LABORATORY STORAGE DEVICES FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, LABORATORY STORAGE TUBES. [ APPARATUS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, DRYERS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY ].


Ng C.,University College London | Osuna-Sanchez H.,Novasep Process | Valery E.,Novasep Process | Bracewell D.,University College London | Sorensen E.,University College London
Computer Aided Chemical Engineering | Year: 2012

Productivity and buffer consumption of protein A chromatography are important process attributes for antibody capture, driven by industry's need to handle increasing upstream titer and market demand economically. In this work, a model-based optimization approach is presented which evaluates the productivity and buffer consumption of protein A chromatography for antibody capture. The approach offers great potential time and costs savings during process development compared with the traditional experimental approach. To demonstrate the application of the proposed model-based optimization approach, the approach is applied to a case study of antibody capture by a novel industrial silica-based protein A adsorbent. © 2012 Elsevier B.V. Source


Ng C.K.S.,University College London | Rousset F.,Novasep Process | Valery E.,Novasep Process | Bracewell D.G.,University College London | Sorensen E.,University College London
Food and Bioproducts Processing | Year: 2014

An integrated experimental and modeling approach for the design of sequential multi-column chromatography (SMCC) is presented to maximize productivity in bioprocessing. The approach consists of three steps: (1) single-column model development and validation, (2) multi-column model development and validation, and (3) productivity optimization. The integrated use of process experimentation and modeling enables sufficient process understanding to be gained during process development such that the optimal SMCC design is found even with limited time and materials. The application of the approach is demonstrated by determining the optimal SMCC design that maximizes the capture of human IgG by a silica-based protein A adsorbent named AbSolute. For this example, the optimum productivity was found to increase from 2.9 kg L-1 day-1 for batch operation to 4.0 kg L-1 day-1 for SMCC operation with three columns. A second case study considering a hypothetical adsorbent of larger particle size and slower mass transfer is also presented, to further demonstrate the applicability of the integrated approach. The case studies clearly illustrate the capabilities of the integrated approach in quickly determining the optimal design and operation for an SMCC arrangement and with minimal, carefully targeted, experimentation. © 2013 The Institution of Chemical Engineers. Source


Ng C.K.S.,University College London | Osuna-Sanchez H.,Novasep Process | Valery E.,Novasep Process | Sorensen E.,University College London | Bracewell D.G.,University College London
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | Year: 2012

An integrated experimental and modeling approach for the design of high productivity protein A chromatography is presented to maximize productivity in bioproduct manufacture. The approach consists of four steps: (1) small-scale experimentation, (2) model parameter estimation, (3) productivity optimization and (4) model validation with process verification. The integrated use of process experimentation and modeling enables fewer experiments to be performed, and thus minimizes the time and materials required in order to gain process understanding, which is of key importance during process development. The application of the approach is demonstrated for the capture of antibody by a novel silica-based high performance protein A adsorbent named AbSolute. In the example, a series of pulse injections and breakthrough experiments were performed to develop a lumped parameter model, which was then used to find the best design that optimizes the productivity of a batch protein A chromatographic process for human IgG capture. An optimum productivity of 2.9kgL -1day -1 for a column of 5mm diameter and 8.5cm length was predicted, and subsequently verified experimentally, completing the whole process design approach in only 75 person-hours (or approximately 2 weeks). © 2012 Elsevier B.V. Source

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