University Nova

Vila Nova de Famalicão, Portugal

University Nova

Vila Nova de Famalicão, Portugal
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Popovic A.,University of Ljubljana | Popovic A.,University NOVA | Hackney R.,Brunel University | Coelho P.S.,University NOVA | And 2 more authors.
Journal of Strategic Information Systems | Year: 2014

Although the constituents of information systems (IS) success and their relationships have been well documented in the business value of information technology (IT) and strategic IS literature, our understanding of how information-sharing values affect the relationships among IS success dimensions is limited. In response, we conduct a quantitative study of 146 medium and large firms that have implemented a business intelligence system in their operations. Our results highlight that in the business intelligence systems context information- sharing values are not directly linked to IT-enabled information use, yet they act as significant moderators of information systems success dimensions relationships. Copyright © 2014 Published by Elsevier B.V. All rights reserved.

Popovic A.,University of Ljubljana | Popovic A.,University Nova | Hackney R.,Brunel University | Coelho P.S.,University Nova | Jaklic J.,University of Ljubljana
Decision Support Systems | Year: 2012

The information systems (IS) literature has long emphasized the positive impact of information provided by business intelligence systems (BIS) on decision-making, particularly when organizations operate in highly competitive environments. Evaluating the effectiveness of BIS is vital to our understanding of the value and efficacy of management actions and investments. Yet, while IS success has been well-researched, our understanding of how BIS dimensions are interrelated and how they affect BIS use is limited. In response, we conduct a quantitative survey-based study to examine the relationships between maturity, information quality, analytical decision-making culture, and the use of information for decision-making as significant elements of the success of BIS. Statistical analysis of data collected from 181 medium and large organizations is combined with the use of descriptive statistics and structural equation modeling. Empirical results link BIS maturity to two segments of information quality, namely content and access quality. We therefore propose a model that contributes to understanding of the interrelationships between BIS success dimensions. Specifically, we find that BIS maturity has a stronger impact on information access quality. In addition, only information content quality is relevant for the use of information while the impact of the information access quality is non-significant. We find that an analytical decision-making culture necessarily improves the use of information but it may suppress the direct impact of the quality of the information content.

Sozio P.,University of Chieti Pescara | Cerasa L.S.,University of Chieti Pescara | Laserra S.,University of Chieti Pescara | Cacciatore I.,University of Chieti Pescara | And 8 more authors.
European Journal of Pharmaceutical Sciences | Year: 2013

The approved treatments for Alzheimer's disease (AD) exploit mainly a symptomatic approach based on the use of cholinesterase inhibitors or N-methyl-d-aspartate (NMDA) receptor antagonists. Natural antioxidant compounds, able to pass through the blood-brain barrier (BBB), have been extensively studied as useful neuroprotective agents. A novel approach towards excitotoxicity protection and oxidative stress associated with excess β amyloid (Aβ) preservation in AD is represented by selective glutamatergic antagonists that possess as well antioxidant capabilities. In the present work, GSH (1) or (R)-α-lipoic acid (LA) (2) have been covalently linked with the NMDA receptor antagonists memantine (MEM). The new conjugates, proposed as potential antialzheimer drugs, should act both as glutamate receptor antagonists and radical scavenging agents. The physico-chemical properties and "in vitro" membrane permeability, the enzymatic and chemical stability, the demonstrated "in vitro" antioxidant activity associated to the capacity to inhibit Aβ(1-42) aggregation makes at least compound 2 a promising candidate for treatment of AD patients. © 2013 Elsevier B.V. All rights reserved.

Lobo L.S.,University Nova | Carabineiro S.A.C.,University of Porto
Fuel | Year: 2016

The evidence of the carbon bulk diffusion mechanism, operating in catalytic carbon gasification, is summarized. Linking visual and structural observations (transmission electron microscopy and X-ray diffraction) with comprehensive kinetic studies offers a good basis to understand the details of the phenomenological behavior. The role of the catalyst nanoparticles in catalytic coal/coke gasification and in graphene reactions is briefly reviewed. Knowledge of the solid-state phases operating under steady-state reaction and of the “sintering like” catalyst-carbon contact is essential to understand the most likely reaction sequence: 1st step - carbon dissolution; 2nd step - C bulk diffusion; 3rd step - surface reaction of emerging C atoms with the reactant gas. Kinetics and preliminary solid-state changes observed in graphite gasification and in coke/coal gasification leads to the conclusion that they follow the same mechanism. Using an analogy with proton exchange membranes in fuel cells: catalytic carbon gasification is promoted by carbon exchange moving nanoparticles. A better understanding of the mechanism may lead to improvements in industrial processes. © 2016 Elsevier Ltd

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