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North College Hill, OH, United States

Notre Dame College, also known as Notre Dame College of Ohio or simply NDC, is a Catholic, coeducational, liberal arts college in South Euclid, Ohio, United States. Established in 1922 as a women's college, it has been coeducational since January 2001. Notre Dame College offers 30 majors and individually designed majors and confers undergraduate and graduate degrees through five academic divisions. The college has a current total enrollment of 2,250 students. The 48-acre main academic and residential campus is located 10 miles east of Cleveland in South Euclid.Fielding athletic teams known as the Notre Dame Falcons, the college is a member of the National Collegiate Athletic Association at the Division II level. Notre Dame is a member of the Mountain East Conference , a Division II conference that began playing in the 2013–14 school year. Prior to joining the NCAA, the college competed in the NAIA as a member of the American Mideast Conference. The official school and athletic colors are royal blue and gold.While the majority of Notre Dame's students are from Ohio, the student body represents 38 states and 19 countries. The college offers a large number of extracurricular activities to its students, including athletics, honor societies, clubs and student organizations. Alumni and former students have gone on to prominent careers in government, business, science, medicine, education, sports, and entertainment. Wikipedia.

Weigold I.K.,University of Akron | Porfeli E.J.,Northeast Ohio Medical University | Weigold A.,Notre Dame College
Psychological Assessment | Year: 2013

One promising antecedent of optimal functioning is personal growth initiative (PGI), which is the active and intentional desire to grow as a person. PGI theory and its measure, the Personal Growth Initiative Scale, have consistently shown positive relations with optimal functioning and growth. Recently, the PGI theory and its measure have been revised to account for theoretical advances. Consequently, testing of the revised theory and measure is needed to assess their capacity to predict psychological functioning and growth. The current study examined 2 tenets of PGI theory in a sample of college students. Results indicated that 3 of the 4 factors of PGI were positively related to psychological well-being and negatively related to aspects of psychological distress. In addition, the same 3 factors were related to growth in a salient domain (vocational identity development) and explained variance beyond that accounted for by more stable personality traits. © 2013 American Psychological Association.

Sofuoglu M.,Yale University | Mouratidis M.,Notre Dame College | Mooney M.,University of Minnesota
Psychoneuroendocrinology | Year: 2011

Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400. mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2. h after the medication treatment. Results: Progesterone treatment, 200. mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400. mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation. © 2010 Elsevier Ltd.

Wepasnick K.A.,Johns Hopkins University | Smith B.A.,Johns Hopkins University | Schrote K.E.,Notre Dame College | Wilson H.K.,University of Maryland Baltimore County | And 2 more authors.
Carbon | Year: 2011

Six commonly used wet chemical oxidants (HNO3, KMnO4, H2SO4/HNO3, (NH4)2S 2O8, H2O2, and O3) were evaluated in terms of their effects on the surface chemistry and structure of MWCNTs using a combination of analytical techniques. X-ray photoelectron spectroscopy (XPS) and energy dispersive spectroscopy (EDX) were used to characterize the extent of surface oxidation, while chemical derivatization techniques used in conjunction with XPS allowed the concentration of carboxyl, carbonyl, and hydroxyl groups at the surface to be quantified for each MWCNT sample. Our results indicate that the distribution of oxygen-containing functional groups was insensitive to the reaction conditions (e.g., w/w% of oxidant), but was sensitive to the identity of the oxidant. MWCNTs treated with (NH4)2S2O8, H2O 2, and O3 yielded higher concentrations of carbonyl and hydroxyl functional groups, while more aggressive oxidants (e.g., HNO 3, KMnO4) formed higher fractional concentrations of carboxyl groups. IR spectroscopy was unable to identify oxygen-containing functional groups present on MWCNTs, while Raman spectra highlighted the frequently ambiguous nature of this technique for measuring CNT structural integrity. TEM was able to provide detailed structural information on oxidized MWCNT, including the extent of sidewall damage for different oxidative treatments. © 2010 Elsevier Ltd. All rights reserved.

Culver M.E.,Notre Dame College | Gatesman M.L.,Virginia Commonwealth University | Mancl E.E.,Virginia Commonwealth University | Lowe D.K.,Virginia Commonwealth University
Annals of Pharmacotherapy | Year: 2011

OBJECTIVE: To review the mechanism of action, pharmacokinetics, efficacy, safety, drug interactions, dosing, and economic considerations of ipilimumab. DATA SOURCES: A literature search using MEDLINE (1966-November 2010) was performed using the terms ipilimumab, metastatic melanoma, MDX-010, and MDX-101. Additional data were obtained from meeting abstracts, bibliographies, and media releases. STUDY SELECTION AND DATA EXTRACTION: English-language articles identified from the data sources were reviewed. Selected studies evaluated the pharmacology, pharmacokinetics, efficacy, and safety of ipilimumab for the treatment of metastatic melanoma. DATA SYNTHESIS: The incidence of melanoma in the US is increasing faster than any other type of cancer in men and more than any other type of cancer, except lung cancer, in women. For patients with metastatic melanoma, systemic therapies are limited by low response rates, short durations of response, and a 5-year survival rate <10%. Ipilimumab, a novel CTLA-4 inhibitor, is under investigation for the treatment of metastatic melanoma. Results of a randomized, controlled Phase 3 trial showed a first-ever overall survival benefit for patients with previously treated metastatic melanoma who received ipilimumab compared with the controls. The majority of adverse events reported with ipilimumab administration are considered to be low-grade immune-related events involving the skin and intestine and can be managed medically. Nonetheless, 10-17% of patients have immune-related adverse events of grade 3 or higher severity, with 2-3% of these events resulting in death. CONCLUSIONS: Ipilimumab is a novel CTLA-4 inhibitor that has been evaluated for the treatment of metastatic melanoma. On March 25, 2011, the Food and Drug Administration approved ipilimumab, making it the first agent indicated for unresectable or metastatic melanoma in more than a decade.

Briscoe W.P.,Notre Dame College | Woodgate R.L.,University of Manitoba
Qualitative Health Research | Year: 2010

Long-term mechanical ventilation (LTMV) is used to support growing numbers of children and adults who develop chronic respiratory failure. The purpose of this hermeneutic phenomenological study was to explore the subjective meaning of the experience of transition from spontaneous breathing to reliance on LTMV. In-depth, audiorecorded interviews of 11 ventilated individuals living in a western Canadian province were transcribed and analyzed. The transition journey was revealed to be a time of psychological, physical, and spiritual challenge. "Sustaining self " was revealed as the essence of ventilator users transition experience. Findings underscore the complex nature of transition to technological reliance, illuminating the need for increased health professional knowledge and understanding of the symptom experience and management options for individuals living with chronic respiratory failure. Strategies to support individuals sense of self as they journey to a life reliant on LTMV are required.

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