Norwegian Environment Agency
Norwegian Environment Agency
Ahmed S.,University of Toronto |
Wang A.,University of Toronto |
Celius T.,Norwegian Environment Agency |
Matthews J.,King's College
Toxicological Sciences | Year: 2014
In this study, we used zinc finger nucleas2-mediated knockout of the aryl hydrocarbon receptor (AHR) or AHR nuclear translocator (ARNT) in MCF7 and AHR knockout in MDA-MB-231 human breast cancer cells to investigate cross talk among AHR, ARNT, and estrogen receptor α (ERα). Knockout of AHR or ARNT prevented the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-dependent induction of all AHR target genes examined. Knockout of AHR or ARNT also significantly reduced basal cytochrome P4501B1 (CYP1B1) expression levels, which were restored with overexpression of either protein but not with a DNA binding-deficient AHR mutant. Basal and TCDD-, 17β-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERα, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHRko and MDA-MB-231 AHRko cells. However, reduced but significant E2-dependent recruitment of ERα, NCoA3, and RNA polymerase II to CYP1B1 and weak increases in CYP1B1 mRNA levels were observed in MCF7 ARNTko cells. Interestingly, E2-dependent increases in trefoil factor 1, but not growth regulation by estrogen in breast cancer 1 (GREB1) mRNA levels, were dependent on ARNT expression. Moreover, the TCDD-dependent increases in the proteolytic degradation of ERα were prevented by the loss of AHR or ARNT. Our data show that AHR and ARNT play critical roles in the basal, TCDD, and E2-induced regulation of CYP1B1 but also reveal distinct roles for both proteins in ERα transactivation. © The Author 2013. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.
News Article | November 18, 2016
Production at Norwegian pharmaceutical company Vistin Pharma ASA's metformin plant in Kragerø, Norway has been temporarily halted due to an unscheduled maintenance stop to repair one of the reactors. The maintenance team at the plant has discovered a fracture in a reactor, which will have to be replaced before normal production can resume. Vistin Pharma estimates that production downtime will last for approximately five weeks and will result in a lowered production volume in the fourth quarter of approximately 300 metric tonnes. Despite this unforeseen event, the Company does not expect any major negative consequences or problems in supplying existing orders, as customers will be supplied from the Company's existing inventory. Vistin Pharma estimates a negative EBITDA-impact in the fourth quarter of NOK 4-5 million from this incident. "We have uncovered a fracture in our metformin reactor which needs to be repaired. Unfortunately, this will take approximately five weeks to resolve. However, we have a good overview of the situation and measures needed to resume production. I can assure all our stakeholders that we are working as hard as we can to repair the component with the goal to resume production as soon as possible," said Kjell-Erik Nordby, CEO of Vistin Pharma. As a consequence of the reactor defect, a discharge of butanol and metformin to water, which exceeded the current permit levels, occurred. The incident has been reported to the Norwegian Environment Agency. The reactor was last inspected during a scheduled inspection by the equipment manufacturer in October 2016, and certified for another five years. Vistin Pharma's metformin plant has been running at full capacity throughout 2016. Earlier this year, the Company decided to invest in a major expansion of the plant, effectively doubling the annual production capacity to in excess of 6 000 metric tonnes. Vistin has a pipeline of new business development opportunities across its metformin business and continues to grow its premium customer base. For further information, please contact: This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act.
Brooks S.J.,Norwegian Institute for Water Research |
Farmen E.,Norwegian Institute for Water Research |
Farmen E.,Norwegian Environment Agency |
Heier L.S.,Norwegian University of Life Sciences |
And 2 more authors.
Aquatic Toxicology | Year: 2015
Mytilus species are important organisms in marine systems being highly abundant and widely distributed along the coast of Europe and worldwide. They are typically used in biological effects studies and have a suite of biological effects endpoints that are frequently measured and evaluated for stress effects in laboratory experiments and field monitoring programmes. Differences in bioaccumulation and biological responses of the three Mytilus species following exposure to copper (Cu) were investigated. A laboratory controlled exposure study was performed with three genetically confirmed Mytilus species; M. galloprovincialis, M. edulis and M. trossulus. Chemical bioaccumulation and biomarkers were assessed in all three Mytilus species following a 4 day and a 21 day exposure to waterborne copper concentrations (0, 10, 100 and 500. μg/L). Differences in copper bioaccumulation were measured after both 4 and 21 days, which suggests some physiological differences between the species. Furthermore, differences in response for some of the biological effects endpoints were also found to occur following exposure. These differences were discussed in relation to either real physiological differences between the species or merely confounding factors relating to the species natural habitat and seasonal cycles. Overall the study demonstrated that differences in chemical bioaccumulation and biomarker responses between the Mytilus spp. occur with potential consequences for mussel exposure studies and biological effects monitoring programmes. Consequently, the study highlights the importance of identifying the correct species when using Mytilus in biological effects studies. © 2014 Elsevier B.V.
Holmern T.,Norwegian University of Science and Technology |
Holmern T.,Norwegian Environment Agency |
Roskaft E.,Norwegian University of Science and Technology
African Journal of Ecology | Year: 2014
Improving the understanding of human-carnivore conflicts is fundamental for the effective management of interventions. However, earlier research has largely focused on conflicts caused by top carnivores, and there is a general lack of knowledge about the drivers behind conflicts caused by smaller carnivores. Here, we investigated the characteristics and spatial patterns of perceived predators that caused losses of poultry. We used a structured interview of 481 households across seven villages outside Serengeti National Park, Tanzania. Most households kept poultry and livestock, and 48.4% of all households perceived to have lost poultry to predators, but it was unrelated to perceived livestock depredation. On average, predators killed almost one-third of the poultry kept by each household, which is equivalent to an average annual economic loss of US $14.5 ± 18.6, or 10.4% of the cash income. Economic dependency did not influence the likelihood of perceiving depredation. The most parsimonious linear mixed-effects model showed that the probability of claiming losses to predators increased with increasing flock sizes and distance to the nearest protected area. We discuss our findings in relation to the current interest in rural poultry production shown by conservation programmes in Africa. © 2013 John Wiley & Sons Ltd.
Olsen S.A.,Norwegian Institute of Marine Research |
Hansen P.K.,Norwegian Institute of Marine Research |
Givskud H.,Norwegian Institute of Marine Research |
Givskud H.,Norwegian Environment Agency |
And 3 more authors.
Aquaculture | Year: 2015
The aquaculture industry supplies coastal waters with large amounts of particulate organic material from the fish cages, which is a source of food for several pelagic and benthic invertebrates and fish. Particularly gadoids, such as cod (Gadus morhua) and saithe (Pollachius virens), are known to aggregate at fish farms in boreal areas. As a step on the way to investigate the influence of organic fish farm waste on wild fish, we conducted a diet-switch study to determine the extent to which fatty acid composition and stable isotopes (δ13C and δ15N) of various tissues could be used to trace diet alterations in cod. Initial analysis of the feeds showed that δ13C results were non-significant and this tracer was not further pursued. Groups of cultivated cod fry (125-200g) were fed either salmon feed, herring fillet or cod feed as control feed and sampling was conducted after 26, 41, 69, 106 and 121days. Fatty acids and stable isotope δ15N were analyzed in the various diets and muscle tissue, and δ15N was determined in the plasma, liver and heart. All fish groups displayed the fatty acid composition of their diets. The salmon feed group had a significant increase of FAs 18:2n6, 18:3n3 and 18:1n9 by the third sampling (day 69). These FAs are found in rich concentrations in vegetable oils used in salmon feed production. The δ15N values showed no significant change in the salmon feed group throughout the experiment whereas the herring group had an increase in all tissues. Linear Discriminant Analysis (LDA) sample distribution plots were identical when FA alone and in combination with the δ15N values were analyzed, and both tests correctly classified more than 96% of the samples. Muscle fatty acids were a more precise tracer than δ15N since specific FAs could be traced and a combination of fatty acid and stable nitrogen analyses did not improve the robustness of the result. © 2014 Elsevier B.V.
News Article | August 29, 2016
Some 323 wild reindeer lie dead after being struck by lightning on a hill side on Hardangervidda mountain plateau in southern Norway on August 27, 2016 (AFP Photo/Haavard Kjontvedt) Oslo (AFP) - More than 300 wild reindeer have been killed by lightning in southern Norway, officials said Monday, in the largest such incident known to date. The 323 reindeer, including 70 young, were found on Friday by a gamekeeper on the Hardangervidda plateau, a national park where Europe's largest herd of some 10,000 wild reindeer roam freely. Television footage showed the animals' dead bodies lying close together on the ground. "There were very strong storms in the area on Friday. The animals stay close together in bad weather and these ones were hit by lightning," an official from the Norwegian Environment Agency, Kjartan Knutsen, told AFP. Reindeer are social creatures and usually move in packs. "It's unusual. We've never seen anything like this on this scale," Knutsen said. Norwegian authorities have yet to decide what to do with the animals. "We're going to decide soon whether to let nature run its own course or whether we will do something," he said. Of the 323 reindeer killed, five had to be put down due to their injuries. Thee are some 25,000 wild tundra reindeer in Norway, located in the southern mountain ranges, according to experts.
News Article | August 29, 2016
A lightning strike that touched down during a severe storm on Friday killed more than 300 reindeer in Norway’s largest national park, according to officials. The herd of 323 animals, 70 of which were calves, was found over the weekend by park officials who were overseeing reindeer hunting season activity in Hardangervidda National Park. According to an official statement, four of the reindeer had to be euthanized due to injuries. The herd was spread out among an area 54 to 84 yards in diameter. As experts explained to the Associated Press, reindeer tend to huddle close together while enduring strong storms. Officials have taken samples from the dead animals as part of a health survey to test for diseases, specifically chronic wasting disease (CWD). CWD is fairly common in North America among elk, white-tailed deer and moose, but the first case in Europe was just reported in April 2016 in a reindeer. The test results may determine if the Norwegian Environment Agency will dispose of the deceased animals, or let nature take its course on the carcasses. The Hardangervidda National Park is the country’s largest national park, covering more than 3,000 square miles. It is also home to the largest herd of freely-roaming reindeer in Europe. In total, there are about 25,000 wild tundra reindeer in Norway, 10,000 of which are located within the park.
News Article | August 29, 2016
More than 300 wild reindeer were killed after being struck by lightning in Norway, in what government officials say was an unusually deadly event. It's not uncommon for wildlife to be killed by lightning strikes, but what made this storm so deadly? Most lightning deaths that occur in groups are due to the ground current, John Jensenius, a lightning safety expert from the National Oceanic and Atmospheric Administration, told The Verge. "First, there's a direct strike — this is what most people think of when they think of lightning — that hits the tree or maybe the ground nearby," Jensenius said. "The energy then spreads along the ground surface, and if you're anywhere near that lightning strike, you absorb it and get shocked." [Electric Earth: Stunning Images of Lightning] The lightning current travels up one leg and down another, Jensenius said, so animals are more vulnerable because their legs are more spread out — the ground currents travel more easily in their bodies. A total of 323 reindeer, including 70 calves, were killed during a lightning storm on Friday (Aug. 26), according to the Norwegian Environment Agency. Of the 323 reindeer killed, five were euthanized because of their injuries, agency officials said. The animals were found in Hardangervidda, a national park that is home to an estimated 10,000 wild reindeer, Europe's largest herd. As herd animals, reindeer typically travel together in large groups. Kjartan Knutsen, a spokesman for the Norwegian Environment Agency, told The Associated Press that reindeer tend to stay very close to each other in bad weather, which could explain how so many were killed at once. Though it is not uncommon for reindeer and other wildlife to be killed by lightning strikes, the agency said this is the deadliest known event to date. Samples were collected from the fallen animals as part of a national survey to test for chronic wasting disease (CWD) — a nervous system disease found in deer and elk that results in brain lesions — according to the Norwegian Environment Agency. Normally, the agency would leave the dead animals where they fell and let nature take its course, but given concerns over the spread of CWD, agency officials said they are waiting for the test results before a final decision is made. Copyright 2016 LiveScience, a Purch company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
News Article | August 29, 2016
More than 300 wild reindeer were killed by a lighting strike in central Norway, according to the Norwegian Environment Agency. During the weekend, the agency released startling images showing a mass of reindeer carcasses scattered across a small area on the Hardangervidda mountain plateau. The incident, while rare, is not without precedent in other parts of the world, where lightning bolts have killed large numbers of cattle, elk and other animals that were clustered together during a thunderstorm. SEE ALSO: Heat wave-related anthrax outbreak in Siberia kills young boy, thousands of reindeer The agency says 323 animals were killed, including 70 calves, in the lightning storm on Friday. This area is home to about 2,000 reindeer at this time of the year, the agency said. Agency spokesman Kjartan Knutsen told The Associated Press it's not uncommon for reindeer or other wildlife to be killed by lightning strikes but this was an unusually deadly event. "We have not heard about such numbers before," he said Monday. He said reindeer tend to stay very close to each other in bad weather, which could explain how so many were killed at once. "I don't know if there were several lighting strikes," he said. "But it happened in one moment." Knutsen said the agency is now discussing what to do with the dead animals. Normally, they are just left where they are to let nature take its course, he said. Thousands of reindeer migrate across the barren Hardangervidda plateau as the seasons change. In the U.S., cattle, elk and other animals are far more likely to die from lightning than people are. In May of this year, lightning killed 21 cattle in South Dakota that were feeding around a metal feeding trough during a thunderstorm. In that case, lightning's current of electricity traveled through the trough, into the cattle, and also into the ground. In the Norwegian incident, it's possible the electrical current from a single bolt, or multiple bolts, proved fatal because the animals were in contact with one another, enabling the electrical current to travel through multiple animals. According to the National Oceanic and Atmospheric Administration (NOAA), 32 people have been killed by lightning in the U.S. so far this year.
News Article | August 29, 2016
The Norwegian Environment Agency has released eerie images showing a jumble of reindeer carcasses scattered across a small area on the Hardangervidda mountain plateau. The agency says 323 animals were killed, including 70 calves, in the lightning storm Friday. Agency spokesman Kjartan Knutsen told The Associated Press it's not uncommon for reindeer or other wildlife to be killed by lightning strikes but this was an unusually deadly event. "We have not heard about such numbers before," he said Monday. He said reindeer tend to stay very close to each other in bad weather, which could explain how so many were killed at once. "I don't know if there were several lightning strikes," he said. "But it happened in one moment." Knutsen said the agency is now discussing what to do with the dead animals. Normally, they are just left where they fall to let nature take its course, he said. Thousands of reindeer migrate across the barren Hardangervidda plateau as the seasons change. In this image made available by the Norwegian Environment Agency on Monday Aug. 29 2016, shows some of the more than 300 wild reindeer that were killed by lighting in Hardangervidda, central Norway on Friday Aug. 26, 2016, in what wildlife officials say was a highly unusual massacre by nature. (Havard Kjotvedt /Norwegian Environment Agency, NTB scanpix, via AP) Explore further: Finnish reindeer glow at night to prevent accidents