Evanston, IL, United States
Evanston, IL, United States

Northwestern University is a private research university with campuses in Evanston and Chicago in Illinois, United States. Home to twelve schools and colleges, Northwestern offers 124 undergraduate degrees and 145 graduate and professional degrees.Northwestern was founded in 1851 by John Evans, for whom the City of Evanston is named, and eight other lawyers, businessmen and Methodist leaders. Its founding purpose was to serve the Northwest Territory, an area that today includes the states of Ohio, Indiana, Illinois, Michigan, Wisconsin and parts of Minnesota. Instruction began in 1855; women were admitted in 1869. Today, the main campus is a 240-acre parcel in Evanston, along the shores of Lake Michigan just 12 miles north of downtown Chicago. The university's law and medical schools are located on a 25-acre campus in Chicago's Streeterville neighborhood. In 2008, the university opened a campus in Education City, Doha, Qatar with programs in journalism and communication.Consistently ranked as a major national and global university, Northwestern is classified as a leading research institution, attracting over $550 million in sponsored research each year. In addition, Northwestern has one of the largest university endowments in the United States, currently valued at $9.8 billion. In 2014, the university accepted 12.9% of undergraduate applicants, making Northwestern one of the most selective universities in the country.Northwestern is a founding member of the Big Ten Conference and remains the only private university in the conference. The Northwestern Wildcats compete in 19 intercollegiate sports in the NCAA's Division I Big Ten Conference. Wikipedia.


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Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.


Patent
Northwestern University | Date: 2016-10-31

Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake. Methods of analyzing, imaging and modulating vesicles and cellular vesicles processes are also provided.


Patent
Northwestern University | Date: 2016-07-29

This invention relates to method and system for forming a film. The method including providing a trough containing water defining an air-water interface between air and the water; providing a solution containing a material of interest; and electrospraying the solution onto the air-water interface of water to form a film of the material of interest at the air-water interface. The system includes a trough containing water defining an air-water interface between air and the water; and means for spreading a solution containing a material of interest onto the air-water interface of water by electrospray, to form a film of the material of interest at the air-water interface. The spreading means comprises an electrospraying device.


Patent
Northwestern University | Date: 2016-10-12

Disclosed herein are conjugates that include a ligand, and a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Z^(1 )is N; Z^(2 )is O or S; L^(1 )and L^(2 )are independently C(O), CR^(1 )or CR^(2); X is a Lewis base; Y^(1 )and Y^(2 )are independently selected from OR^(3), OR^(4), SR^(3 )and SR^(4), wherein R^(1 )and R^(2 )are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C_(1)-C_(10 )alkyl, C_(1)-C_(10 )alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C_(3)-C_(15 )cycloalkyl, heteroaryl, and C_(3)-C_(15 )heterocycloalkyl; and R^(3 )and R^(4 )are independently selected from hydrogen, C_(1)-C_(10 )alkyl, C_(1)-C_(10 )alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C_(3)-C_(15 )cycloalkyl, heteroaryl, and C_(3)-C_(15 )heterocycloalkyl.


Patent
Northwestern University | Date: 2016-08-17

Provided herein are anti-inflammatory nanofibers and methods of use thereof. In particular methods are provided for the use of anti-inflammatory nanofibers in the promotion of tissue (e.g., urinary bladder tissue) regeneration.


The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.


Patent
Northwestern University and The General Hospital Corporation | Date: 2016-06-20

Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntingtons disease.


Patent
Cambria Pharmaceuticals Inc. and Northwestern University | Date: 2017-03-22

The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) of formula (I) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.


Patent
Northwestern University | Date: 2017-02-01

Methods of synthesizing a DOPA-melanin (DM) polymer are disclosed, as well as compositions comprising the DM polymer and uses thereof. The method comprises contacting a reactant such as 3,4-dihydroxyphenylalanine (DOPA) with a high concentration aqueous salt solution under oxidative conditions. The resulting DM polymer may form as insoluble particles or as a coating on a substrate surface. Exemplary uses for the DM polymers include removing heavy metal ions from contaminated solutions or capturing and delivering cationic drugs such as gentamicin.


Patent
Glaxosmithkline and Northwestern University | Date: 2017-01-25

Disclosed are methods for treating cancer such as a myeloid malignancy such as multiple myeloma in a human using EZH2 inhibitors in human populations having a translocation MMSET or a decreased level of a functional UTX protein or both.

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