Northwestern University is a private research university with campuses in Evanston and Chicago in Illinois, United States. Home to twelve schools and colleges, Northwestern offers 124 undergraduate degrees and 145 graduate and professional degrees.Northwestern was founded in 1851 by John Evans, for whom the City of Evanston is named, and eight other lawyers, businessmen and Methodist leaders. Its founding purpose was to serve the Northwest Territory, an area that today includes the states of Ohio, Indiana, Illinois, Michigan, Wisconsin and parts of Minnesota. Instruction began in 1855; women were admitted in 1869. Today, the main campus is a 240-acre parcel in Evanston, along the shores of Lake Michigan just 12 miles north of downtown Chicago. The university's law and medical schools are located on a 25-acre campus in Chicago's Streeterville neighborhood. In 2008, the university opened a campus in Education City, Doha, Qatar with programs in journalism and communication.Consistently ranked as a major national and global university, Northwestern is classified as a leading research institution, attracting over $550 million in sponsored research each year. In addition, Northwestern has one of the largest university endowments in the United States, currently valued at $9.8 billion. In 2014, the university accepted 12.9% of undergraduate applicants, making Northwestern one of the most selective universities in the country.Northwestern is a founding member of the Big Ten Conference and remains the only private university in the conference. The Northwestern Wildcats compete in 19 intercollegiate sports in the NCAA's Division I Big Ten Conference. Wikipedia.
Cambria Pharmaceuticals Inc. and Northwestern University | Date: 2017-03-22
The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) of formula (I) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
Northwestern University and University of Minnesota | Date: 2017-02-20
A method of fabricating a CMOS logic device with SWCNTs includes forming a plurality of local metallic gate structures on a substrate by depositing a metal on the substrate; forming a plurality of contacts on the substrate; and depositing the SWCNTs on the substrate, and doping a certain area of the SWCNTs to form the CMOS logic device having at least one NMOS transistor and at least one PMOS transistor. Each of the NMOS and PMOS transistors has a gate formed by one of the local metallic gate structures, and a source and a drain formed by two of the contacts respectively. The gate of each PMOS transistor and the gate of each NMOS transistor are configured to alternatively receive at least one input voltage. At least one of the drain of the PMOS transistor and the drain of the NMOS transistor is configured to output an output voltage.
Baxter International, Baxter Healthcare Sa and Northwestern University | Date: 2017-03-03
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
Northwestern University and Resonance Medical Llc | Date: 2017-03-06
A cochlear implant includes electrodes and a processor for generating frequency-modulated electrical pulse trains in one or more of the electrodes responsive to dividing data representing audio spanning frequency-bands into bins associated with each frequency-band, each bin representing an energy level of the data within the frequency-band within a time-period; associating each frequency-band with a phase probability that starts at an initial phase probability value (PPV), resets to a minimum PPV after generating a pulse, and increases from the minimum PPV to a maximum PPV over a time-period; for each bin, assigning a power probability as a normalized intensity being a number between a minimum power probability and a maximum power probability representing the energy level of the bin, and generating a pulse in an electrode associated with the frequency-band associated with the bin when a random number generated is less than the power probability divided by the phase probability.
Northwestern University | Date: 2017-03-09
The invention relates generally to methods of detecting reactive oxygen species (ROS) in cardiac tissue and treatment modalities for ablating ROS-associated tissue in cardiac disease. The methods rely upon targeting ROS-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded atrial EGMs for a tissue to assess ROS content and underlying AF organization as a function of ROS blockade conditions.
Northwestern University | Date: 2017-06-14
Disclosed are methods for isolating, cultivating, and/or cells including regulatory T cells (Tregs). The methods typicaily include cultivating cells including Trees in a culture media comprising a ligand for programmed cell death receptor (PD-1) conjugated to a solid support. Suitable ligands may include PD-L1 and suitable solid supports may include magnetic or paramagnetic beads where the methods further include removing the PD-L1/ bead conjugates after the Tregs have been isolated, cultured, and/or expanded.
Northwestern University | Date: 2017-02-09
Disclosed are methods for preparing and screening for an inhibitor of the activity of a biological molecule having a catalytic or non-catalytic cysteine residue. The methods including preparing a library of candidate inhibitor molecules by conjugating an electrophile to a plurality of drug molecules where the library of candidate inhibitor molecules thus formed react with cysteine residues. The library of candidate inhibitor molecules then may be reacted with the biological molecule to identify those inhibitor molecule that react with the catalytic or non-catalytic cysteine residue of the biological molecule in order to identify an inhibitor of the biological molecule.
Northwestern University | Date: 2017-04-05
Motion contrast depth scanning is disclosed herein. A disclosed example apparatus includes an illumination source that is to provide at least one of spatial or temporal changes to light emitted from the illumination source to a scene. The example apparatus also includes a motion contrast sensor, where pixels of the motion contrast sensor are to detect changes corresponding to the scene, and where the motion contrast sensor is to report measurements when a pixel change exceeds a threshold. The example apparatus further includes a processor to determine at least one of a reflectance, a depth, or movement of the scene based on the reported measurements by the motion contrast sensor.
Scripps Research Institute and Northwestern University | Date: 2017-03-29
By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
Northwestern University | Date: 2017-01-09
Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.