Evanston, IL, United States
Evanston, IL, United States

Northwestern University is a private research university with campuses in Evanston and Chicago in Illinois, United States. Home to twelve schools and colleges, Northwestern offers 124 undergraduate degrees and 145 graduate and professional degrees.Northwestern was founded in 1851 by John Evans, for whom the City of Evanston is named, and eight other lawyers, businessmen and Methodist leaders. Its founding purpose was to serve the Northwest Territory, an area that today includes the states of Ohio, Indiana, Illinois, Michigan, Wisconsin and parts of Minnesota. Instruction began in 1855; women were admitted in 1869. Today, the main campus is a 240-acre parcel in Evanston, along the shores of Lake Michigan just 12 miles north of downtown Chicago. The university's law and medical schools are located on a 25-acre campus in Chicago's Streeterville neighborhood. In 2008, the university opened a campus in Education City, Doha, Qatar with programs in journalism and communication.Consistently ranked as a major national and global university, Northwestern is classified as a leading research institution, attracting over $550 million in sponsored research each year. In addition, Northwestern has one of the largest university endowments in the United States, currently valued at $9.8 billion. In 2014, the university accepted 12.9% of undergraduate applicants, making Northwestern one of the most selective universities in the country.Northwestern is a founding member of the Big Ten Conference and remains the only private university in the conference. The Northwestern Wildcats compete in 19 intercollegiate sports in the NCAA's Division I Big Ten Conference. Wikipedia.


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Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.


Patent
Northwestern University | Date: 2016-10-31

Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake. Methods of analyzing, imaging and modulating vesicles and cellular vesicles processes are also provided.


Patent
Northwestern University | Date: 2015-05-06

This disclosure features combinations of NMDAR modulating compounds. This disclosure features combinations that include one or more NMDAR antagonists and GLYX-13 (each of which is sometimes referred to herein as a component). The beneficial effects of the combination are based, in part, on the finding that administration of GLYX-13 (e.g., a single dose) can reverse and/or prevent NMDAR antagonist-induced cognitive impairment (e.g., NMDAR antagonist-induced impairment in novel object recognition; e.g., induced through repeated dosing of the NMDAR antagonist).


Patent
Northwestern University | Date: 2016-08-19

The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or an inhibitor of the Na_(x)/SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating skin conditions (e.g., dermatitis, psoriasis, or other skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a gene or protein selected from: ENac, COX-2, PGE2, PI3K, PKB, Na_(x )Prss8, IL-1, IL-8, SAPK, Erk gene, p38 gene, PAR2, S100A8, S100A9, S100A12.


3D printable ink compositions for forming objects, films and coatings are provided. Also provided are methods of printing the ink compositions and methods for making the ink compositions. The ink compositions include an elastic polymer binder and may have high loadings of solid particles.


Patent
Northwestern University and President And Fellows Of Harvard College | Date: 2015-08-24

A rapid, scalable methodology for graphene dispersion and concentration with a polymer-organic solvent medium, as can be utilized without centrifugation, to enhance graphene concentration.


Patent
Northwestern University | Date: 2016-10-28

Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain is a sequence of nucleobases or phosphate groups, such as a poly thymidine (polyT) sequence or a phosphate polymer (C3 residue) and may be located 5 to the oligonucleotide 3 to the oligonucleotide, within, or colinear with the oligonucleotide. Usage of the nanoparticles including modulating gene regulation is contemplated.


Patent
Northwestern University | Date: 2016-09-28

Provided herein are compositions comprising covalent and supramolecular polymers, and methods of preparation and use thereof.


Patent
Northwestern University | Date: 2016-07-29

This invention relates to method and system for forming a film. The method including providing a trough containing water defining an air-water interface between air and the water; providing a solution containing a material of interest; and electrospraying the solution onto the air-water interface of water to form a film of the material of interest at the air-water interface. The system includes a trough containing water defining an air-water interface between air and the water; and means for spreading a solution containing a material of interest onto the air-water interface of water by electrospray, to form a film of the material of interest at the air-water interface. The spreading means comprises an electrospraying device.


Patent
Northwestern University | Date: 2016-10-12

Disclosed herein are conjugates that include a ligand, and a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Z^(1 )is N; Z^(2 )is O or S; L^(1 )and L^(2 )are independently C(O), CR^(1 )or CR^(2); X is a Lewis base; Y^(1 )and Y^(2 )are independently selected from OR^(3), OR^(4), SR^(3 )and SR^(4), wherein R^(1 )and R^(2 )are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C_(1)-C_(10 )alkyl, C_(1)-C_(10 )alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C_(3)-C_(15 )cycloalkyl, heteroaryl, and C_(3)-C_(15 )heterocycloalkyl; and R^(3 )and R^(4 )are independently selected from hydrogen, C_(1)-C_(10 )alkyl, C_(1)-C_(10 )alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C_(3)-C_(15 )cycloalkyl, heteroaryl, and C_(3)-C_(15 )heterocycloalkyl.


Reorganizable or reprocessable cross-linked polymer networks with alkoxyamine dynamic covalent bonds and methods for preparation.


Patent
Northwestern University | Date: 2016-08-17

Provided herein are anti-inflammatory nanofibers and methods of use thereof. In particular methods are provided for the use of anti-inflammatory nanofibers in the promotion of tissue (e.g., urinary bladder tissue) regeneration.


Patent
Northwestern University | Date: 2016-11-29

An engineered ribosome that includes a tethered subunit arrangement is disclosed, in which the engineered ribosome supports translation of a sequence defined polymer. Methods for making and using the engineered ribosome are also disclosed, including a method for preparing a sequence defined polymer using the engineered ribosome and a method for preparing a sequence defined polymer using the engineered ribosome in a two-protein translation system. The engineered ribosomes may be utilized in methods for incorporating unnatural amino acids into a sequence defined polymer. Also disclosed are optimized polynucleotide sequences for use as tethers and Shine-Dalgarno/anti-Shine-Dalgarno sequences.


The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.


Patent
Northwestern University and The General Hospital Corporation | Date: 2016-06-20

Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntingtons disease.


Patent
Johns Hopkins University and Northwestern University | Date: 2015-05-06

Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.


Nanostructured carbon electrode usable for electrochemical devices and methods of fabricating the same. The method of fabricating a nanostructured carbon electrode includes providing a carbon material of polyaromatic hydrocarbon (PAH), mixing the carbon material of PAH with a surfactant in a solution to form a suspension thereof; depositing the suspension onto a substrate to form a layered structure; and sintering the layered structure at a temperature for a period of time to form a nanostructured carbon electrode having a film of PAH.


A method for forming a lubrication material using self-dispersed crumpled graphene balls as additives in a lubricant base fluid for friction and wear reduction. The lubricant base fluid may be, for example, a polyalphaolefin type-4 (PAO4) oil. After the crumpled graphene balls are added as additives in the lubricant base fluid, the lubricant base fluid with the additives are sonicated for a sonicating time period, so that the crumpled graphene balls are self-dispersed in the lubricant base fluid to improve friction and wear properties of the lubricant base fluid. In some cases, a dispersing agent, such as Triethoxysilane, may be added in the lubricant base fluid to enhance stability of dispersion of the crumpled graphene balls in the lubricant base fluid. The crumpled graphene balls may stay stably dispersed in the lubricant base fluid between a lower temperature (such as 15 C.) to a higher temperature (such as 90 C.).


Patent
Northwestern University | Date: 2016-08-30

Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.


Polymeric compositions comprising as-received organic waste materials comprising an antioxidant component for enhanced thermal stability.


Patent
NanoAl LLC and Northwestern University | Date: 2016-09-12

Aluminum-zirconium and aluminum-zirconium-lanthanide superalloys are described that can be used in high temperature, high stress and a variety of other applications. The lanthanide is preferably holmium, erbium, thulium or ytterbium, most preferably erbium. Also, methods of making the aforementioned alloys are disclosed. The superalloys, which have commercially-suitable hardness at temperatures above about 220 C., include nanoscale Al_(3)Zr precipitates and optionally nanoscale Al_(3)Er precipitates and nanoscale Al_(3)(Zr,Er) precipitates that create a high-strength alloy capable of withstanding intense heat conditions. These nanoscale precipitates have a L1_(2)-structure in -Al(f.c.c.) matrix, an average diameter of less than about 20 nanometers (nm), preferably less than about 10 nm, and more preferably about 4-6 nm and a high number density, which for example, is larger than about 10^(21 )m^(3), of the nanoscale precipitates. The formation of the high number density of nanoscale precipitates is thought to be due to the addition of inoculant, such as a Group 3A, 4A, and 5A metal or metalloid. Additionally, methods for increasing the diffusivity of Zr in Al are disclosed.


Patent
Northwestern University | Date: 2015-05-22

Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.


Ferroelectric barium titanate (BaTiO_(3)) epitaxial films grown by metal-organic chemical vapor deposition using a barium precursor having a low melting point and a stable vapor pressure.


Patent
Northwestern University | Date: 2016-10-18

The present invention relates generally to the detection or diagnosis of depressive disorders, and provides methods and compositions useful for this purpose. In particular, the present invention provides biomarkers for the detection or diagnosis of major depressive disorder, and methods of use thereof.


A system and method include a shield application executing on a processor. The shield application can convert a business application to provide data isolation between the business application and personal applications, and data sharing between the business application and other business applications, e.g., in the bring-your-own-device and enterprise mobility management scenarios.


Patent
Cambria Pharmaceuticals Inc. and Northwestern University | Date: 2017-03-22

The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) of formula (I) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.


Paice J.A.,Northwestern University
CA Cancer Journal for Clinicians | Year: 2011

The experience of pain in cancer is widely accepted as a major threat to quality of life, and the relief of pain has emerged as a priority in oncology care. Pain is associated with both the disease as well as treatment, and management is essential from the onset of early disease through long-term survivorship or end-of-life care. Effective relief of pain is contingent upon a comprehensive assessment to identify physical, psychological, social, and spiritual aspects and as a foundation for multidisciplinary interventions. Fortunately, advances in pain treatment and in the field of palliative care have provided effective treatments encompassing pharmacological, cognitive-behavioral, and other approaches. The field of palliative care has emphasized that attention to symptoms such as pain is integral to quality cancer care. © 2011 American Cancer Society, Inc.


Salvo A.,National University of Singapore | Geiger F.M.,Northwestern University
Nature Geoscience | Year: 2014

Ethanol-based vehicles are thought to generate less pollution than gasoline-based vehicles, because ethanol emissions contain lower concentrations of mono-nitrogen oxides than those from gasoline emissions. However, the predicted effect of various gasoline/ethanol blends on the concentration of atmospheric pollutants such as ozone varies between model and laboratory studies, including those that seek to simulate the same environmental conditions. Here, we report the consequences of a real-world shift in fuel use in the subtropical megacity of São Paulo, Brazil, brought on by large-scale fluctuations in the price of ethanol relative to gasoline between 2009 and 2011. We use highly spatially and temporally resolved observations of road traffic levels, meteorology and pollutant concentrations, together with a consumer demand model, to show that ambient ozone concentrations fell by about 20% as the share of bi-fuel vehicles burning gasoline rose from 14 to 76%. In contrast, nitric oxide and carbon monoxide concentrations increased. We caution that although gasoline use seems to lower ozone levels in the São Paulo metropolitan area relative to ethanol use, strategies to reduce ozone pollution require knowledge of the local chemistry and consideration of other pollutants, particularly fine particles. © 2014 Macmillan Publishers Limited.


Pandolfino J.E.,Northwestern University
The Lancet | Year: 2013

Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options.


Kushner R.F.,Northwestern University | Ryan D.H.,Pennington Biomedical Research Center
JAMA - Journal of the American Medical Association | Year: 2014

IMPORTANCE: Even though one-third of US adults are obese, identification and treatment rates for obesity remain low. Clinician engagement is vital to provide guidance and assistance to patients who are overweight or obese to address the underlying cause of many chronic diseases. OBJECTIVES: To describe current best practices for assessment and lifestyle management of obesity and to demonstrate how the updated Guidelines (2013) for Managing Overweight and Obesity in Adults based on a systematic evidence review sponsored by the National Heart, Lung, and Blood Institute (NHLBI) can be applied to an individual patient. EVIDENCE REVIEW: Systematic evidence review conducted for the Guidelines (2013) for Managing Overweight and Obesity in Adults supports treatment recommendations in 5 areas (risk assessment, weight loss benefits, diets forweight loss, comprehensive lifestyle intervention approaches, and bariatric surgery); for areas outside this scope, recommendations are supported by other guidelines (for obesity, 1998 NHLBI-sponsored obesity guidelines and those from the National Center for Health and Clinical Excellence and Canadian and US professional societies such as the American Association of Clinical Endocrinologists and American Society of Bariatric Physicians; for physical activity recommendations, the 2008 Physical Activity Guidelines for Americans); a PubMed search identified recent systematic reviews covering depression and obesity, motivational interviewing forweight management, metabolic adaptation toweight loss, and obesity pharmacotherapy. FINDINGS: The first step in obesity management is to screen all adults for overweight and obesity. A medical history should be obtained assessing for the multiple determinants of obesity, including dietary and physical activity patterns, psychosocial factors, weight-gaining medications, and familial traits. Emphasis on the complications of obesity to identify patients who will benefit the most from treatment is more useful than using body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) alone for treatment decisions. The Guidelines (2013) recommend that clinicians offer patients who would benefit from weight loss (either BMI of ≥30 with or without comorbidities or ≥25 along with 1 comorbidity or risk factor) intensive, multicomponent behavioral intervention. Some clinicians do this within their primary care practices; others refer patients for these services. Weight loss is achieved by creating a negative energy balance through modification of food and physical activity behaviors. The Guidelines (2013) endorse comprehensive lifestyle treatment by intensive intervention. Treatment can be implemented either in a clinician's office or by referral to a registered dietitian or commercial weight loss program. Weight loss of 5%to 10% is the usual goal. It is not necessary for patients to attain a BMI of less than 25 to achieve a health benefit. CONCLUSIONS AND RELEVANCE Screening and assessment of patients for obesity followed by initiation or referral of treatment should be incorporated into primary care practice settings. If clinicians can identify appropriate patients for weight loss efforts and provide informed advice and assistance on how to achieve and sustain modest weight loss, they will be addressing the underlying driver of many comorbidities and can have a major influence on patients' health status. Copyright 2014 American Medical Association. All rights reserved.


Patent
Northwestern University and University of Illinois at Urbana - Champaign | Date: 2015-04-02

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subjects stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis).


Patent
University of Illinois at Urbana - Champaign, Trustees Of Tufts College, University of Pennsylvania and Northwestern University | Date: 2016-01-20

Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2014-10-22

Disclosed herein are stretchable, foldable and optionally printable, processes for making devices and devices such as semiconductors, electronic circuits and components thereof that are capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Strain isolation layers provide good strain isolation to functional device layers. Multilayer devices are constructed to position a neutral mechanical surface coincident or proximate to a functional layer having a material that is susceptible to strain-induced failure. Neutral mechanical surfaces are positioned by one or more layers having a property that is spatially inhomogeneous, such as by patterning any of the layers of the multilayer device.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2015-05-07

Disclosed herein are stretchable, foldable and optionally printable, processes for making devices and devices such as semiconductors, electronic circuits and components thereof that are capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Strain isolation layers provide good strain isolation to functional device layers. Multilayer devices are constructed to position a neutral mechanical surface coincident or proximate to a functional layer having a material that is susceptible to strain-induced failure. Neutral mechanical surfaces are positioned by one or more layers having a property that is spatially inhomogeneous, such as by patterning any of the layers of the multilayer device.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2014-02-05

The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.


Patent
Northwestern University and University of Illinois at Urbana - Champaign | Date: 2015-01-28

The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.


Grant
Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase II | Award Amount: 374.99K | Year: 2013

Detecting light at the single photon level is a fundamental measurement function that is useful in a wide variety of applications, including such diverse fields as quantum communications, laser ranging, and biological spectroscopy. Avalanche photodiode based single-photon detectors are convenient solid-state devices that do not require cryogenic cooling. We will build avalanche photodiode based single-photon-detection systems that make use of advanced gating techniques to improve their count rate. The single-photon detectors will be used in quantum measurement, such as entanglement distribution, and lidar applications. We will also use nonlinear frequency conversion to enable improved single-photon detectors in the telecom-wavelength bands around 1.3 and 1.5 microns.


Patent
University of Illinois at Urbana - Champaign, Northwestern University and University of Miami | Date: 2014-04-03

The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2016-01-06

Disclosed herein is an electronic device comprising a substrate, a plurality of device islands supported by said substrate; and a serpentine electrical interconnect having a first end electrically connected to a first device island and a second end electrically connected to a second device island.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2014-02-05

The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in a configuration allowing for elastic deformations to occur in a repeatable and well-defined way. The stretchable device geometries and hard-soft materials integration approaches of the invention provide a combination of advance electronic function and compliant mechanics supporting a broad range of device applications including sensing, actuation, power storage and communications.


Patent
University of Illinois at Urbana - Champaign and Northwestern University | Date: 2015-11-17

Origami- and Kirigami-inspired assembly of predetermined three-dimensional forms is presented in comprehensive theoretical and experimental studies, with examples of a broad range of topologies and material compositions. The resulting engineering options in the construction of functional 3D structures have important implications for advanced microsystem technologies.


Patent
Northwestern University, University of Strasbourg and French National Center for Scientific Research | Date: 2014-12-03

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimers disease), for research, drug screening, and therapeutic applications.


Patent
Northwestern University and Ann & Robert H Lurie Childrens Hospital Of Chicago | Date: 2015-02-18

Provided herein are populations of bone marrow mesenchymal stem cells (MSCs) and CD34+ hematopoietic stem/progenitor cells (HSPCs), and methods of isolation and co-administration thereof. In particular, cell populations and methods of co-administration thereof are provided for enhancing tissue (e.g., bladder) regeneration.


Patent
Northwestern University, University of Strasbourg and French National Center for Scientific Research | Date: 2016-06-29

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimers disease), for research, drug screening, and therapeutic applications.


Grant
Agency: Department of Defense | Branch: Air Force | Program: STTR | Phase: Phase I | Award Amount: 149.99K | Year: 2014

ABSTRACT: The secure transmission of digital information is of extreme importance for military and commercial applications. The need for protecting information from hostile eavesdroppers has motivated the search for novel security schemes. This EPR-based Quantum Key Distribution (QKD) approach promises to provide a final solution to the problem by insuring ultimate security based upon the laws of quantum mechanics. Numerous experiments demonstrating QKD have been conducted in both fiber and free space configurations. While the performance of these systems in terms of key rates and distance is below that seen in classical transmission of information, the security promised by QKD makes it an enticing technology. The last frontier for QKD is satellite to ground and satellite to satellite applications, where the need is great to have extremely high secure method for communications. To address this potential, SA Photonics proposes to develop the QE-Sphinx QKD system for ground-LEO applications. The QE-Sphinx system will provide robust, high performance key distribution with increased secure key rates by employing the following techniques: - Innovative QMM and DSS single-photon APD architectures - EPR-based BB84 protocol and - Low loss optical and fiber-optic components BENEFIT: SA Photonics will use our QMM and DSS architectures and EPR-based BB84 protocol to develop a high secure key rate and robust ground-LEO QKD system. There are multiple benefits to the Air Force: - Low development cost - Proven EPR-based BB84 protocol - Improved QoS by increasing secure key rates - Rugged and reliable


Patent
Northwestern University and Resonance Medical Llc | Date: 2016-07-11

A method of generating frequency-modulated pulse trains in a CI includes dividing data representing audio spanning frequency bands into a plurality of bins associated with each frequency band, each bin representing an energy level of the data within the frequency band within a period of time; associating each frequency band with a phase probability that starts at an initial phase probability value (PPV), resets to a minimum PPV after generating a pulse, and increases from the minimum PPV to a maximum PPV over a period of time; for each bin, assigning a power probability as a normalized intensity being a number between a minimum power probability and a maximum power probability representing the energy level of the bin, and generating a pulse in an electrode associated with the frequency band associated with the bin when a random number generated is less than the power probability divided by the phase probability.


Patent
Northwestern University, Ann & Robert H Lurie Childrens Hospital Of Chica and University of Maryland, Baltimore | Date: 2016-03-29

The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.


Mauvais-Jarvis F.,Northwestern University | Clegg D.J.,University of Texas Southwestern Medical Center | Hevener A.L.,University of California at Los Angeles
Endocrine Reviews | Year: 2013

Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular, skeletal, and central nervous systems. In this report, we review the literature in both rodents and humans on the role of estrogens and their receptors in the control of energy homeostasis and glucose metabolism in health and metabolic diseases. Estrogen actions in hypothalamic nuclei differentially control food intake, energy expenditure, and white adipose tissue distribution. Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity as well as prevention of lipid accumulation and inflammation. Estrogen actions in pancreatic islet β-cells also regulate insulin secretion, nutrient homeostasis, and survival. Estrogen deficiency promotes metabolic dysfunction predisposing to obesity, the metabolic syndrome, and type 2 diabetes. We also discuss the effect of selective estrogen receptor modulators on metabolic disorders. © 2013 by The Endocrine Society.


Bostwick J.B.,Northwestern University | Steen P.H.,Cornell University
Annual Review of Fluid Mechanics | Year: 2015

A capillary surface is an interface between two fluids whose shape is determined primarily by surface tension. Sessile drops, liquid bridges, rivulets, and liquid drops on fibers are all examples of capillary shapes influenced by contact with a solid. Capillary shapes can reconfigure spontaneously or exhibit natural oscillations, reflecting static or dynamic instabilities, respectively. Both instabilities are related, and a review of static stability precedes the dynamic case. The focus of the dynamic case here is the hydrodynamic stability of capillary surfaces subject to constraints of (a) volume conservation, (b) contact-line boundary conditions, and (c) the geometry of the supporting surface. Copyright © 2015 by Annual Reviews. All rights reserved.


Patent
Baxter International, Baxter Healthcare SA and Northwestern University | Date: 2015-01-27

Systems and methods for automated detection and classification of objects in a fluid of a receptacle such as, for example, a soft-sided receptacle such as a flexible container. The automated detection may include initiating movement of the receptacle to move objects in the fluid contained by the receptacle. Sequential frames of image data may be recorded and processed to identify moving objects in the image data. In turn, at least one motion parameter of the objects may be determined and utilized to classify the object into at least one of a predetermined plurality of object classes. For example, the object classes may at least include a predetermined class corresponding to bubbles and a predetermined class corresponding to particles.


Patent
Baxter International, Northwestern University and Baxter Healthcare Sa | Date: 2014-03-14

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.


Patent
Baxter International, Baxter Healthcare Sa and Northwestern University | Date: 2014-06-06

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.


Blair N.E.,Northwestern University | Aller R.C.,State University of New York at Stony Brook
Annual Review of Marine Science | Year: 2012

Understanding the fate of terrestrial organic carbon (C org) delivered to oceans by rivers is critical for constraining models of biogeochemical cycling and Earth surface evolution. C org fate is dependent on both intrinsic characteristics (molecular structure, matrix) and the environmental conditions to which fluvial C org is subjected. Three distinct patterns are evident on continental margins supplied by rivers: (a) high-energy, mobile muds with enhanced oxygen exposure and efficient metabolite exchange have very low preservation of both terrestrial and marine C org (e.g., Amazon subaqueous delta); (b) low-energy facies with extreme accumulation have high C org preservation (e.g., Ganges-Brahmaputra); and (c) small, mountainous river systems that sustain average accumulation rates but deliver a large fraction of low-reactivity, fossil Corg in episodic events have the highest preservation efficiencies. The global patterns of terrestrial C org preservation reflect broadly different roles for passive and active margin systems in the sedimentary C org cycle. Copyright © 2012 by Annual Reviews. All rights reserved.


De Vos M.,Center for Reproductive Medicine | Smitz J.,Laboratory of Clinical Chemistry and Radioimmunology | Woodruff T.K.,Northwestern University
The Lancet | Year: 2014

Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with cancer. Present data suggest that young patients with cancer should be referred for fertility preservation counselling quickly to help with their coping process. Although the clinical application of novel developments, including oocyte vitrification and oocyte maturation in vitro, has resulted in reasonable success rates in assisted reproduction programmes, experience with these techniques in the setting of fertility preservation is in its infancy. It is hoped that these and other approaches, some of which are still regarded as experimental (eg, ovarian tissue cryopreservation, pharmacological protection against gonadotoxic agents, in-vitro follicle growth, and follicle transplantation) will be optimised and become established within the next decade. Unravelling the complex mechanisms of activation and suppression of follicle growth will not only expand the care of thousands of women diagnosed with cancer, but also inform the care of millions of women confronted with reduced reproductive fitness because of ageing.

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