Northwestern University is a private research university with campuses in Evanston and Chicago in Illinois, United States. Home to twelve schools and colleges, Northwestern offers 124 undergraduate degrees and 145 graduate and professional degrees.Northwestern was founded in 1851 by John Evans, for whom the City of Evanston is named, and eight other lawyers, businessmen and Methodist leaders. Its founding purpose was to serve the Northwest Territory, an area that today includes the states of Ohio, Indiana, Illinois, Michigan, Wisconsin and parts of Minnesota. Instruction began in 1855; women were admitted in 1869. Today, the main campus is a 240-acre parcel in Evanston, along the shores of Lake Michigan just 12 miles north of downtown Chicago. The university's law and medical schools are located on a 25-acre campus in Chicago's Streeterville neighborhood. In 2008, the university opened a campus in Education City, Doha, Qatar with programs in journalism and communication.Consistently ranked as a major national and global university, Northwestern is classified as a leading research institution, attracting over $550 million in sponsored research each year. In addition, Northwestern has one of the largest university endowments in the United States, currently valued at $9.8 billion. In 2014, the university accepted 12.9% of undergraduate applicants, making Northwestern one of the most selective universities in the country.Northwestern is a founding member of the Big Ten Conference and remains the only private university in the conference. The Northwestern Wildcats compete in 19 intercollegiate sports in the NCAA's Division I Big Ten Conference. Wikipedia.
Cambria Pharmaceuticals Inc. and Northwestern University | Date: 2017-03-22
The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) of formula (I) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
Northwestern University | Date: 2017-01-23
A method of using a metal organic framework (MOF) comprising a metal ion and an at least bidendate organic ligand to catalytically detoxify chemical warfare nerve agents including exposing the metal-organic-framework (MOF) to the chemical warfare nerve agent and catalytically decomposing the nerve agent with the MOF.
Northwestern University | Date: 2017-01-19
Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.
Northwestern University | Date: 2017-01-17
Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). Certain embodiments provide a method of preventing hypertrophic scar formation in a subject comprising administering a HMG-CoA reductase-inhibiting agent to a wound site. In some embodiments, the wound site comprises scar tissue.
Northwestern University | Date: 2017-01-12
A system includes a chest tube drainage system comprising a first chamber in fluid communication with a port connectable to a chest tube, a second chamber in fluid communication with a port connectable to a suction device, and a fluid seal connected to and disposed between the first chamber and the second chamber. The system also includes one or more gas sensors attached to the chest tube drainage system, the one or more gas sensors configured to detect at least one of gaseous carbon dioxide and gaseous oxygen, a controller connected to the one or more gas sensors, and at least one indicator coupled to the controller. The controller is configured to determine if a threshold level of carbon dioxide is exceeded, and to activate the at least one indicator if the threshold level of carbon dioxide is not exceeded.
Northwestern University | Date: 2017-03-08
The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
Northwestern University | Date: 2017-02-01
Methods of synthesizing a DOPA-melanin (DM) polymer are disclosed, as well as compositions comprising the DM polymer and uses thereof. The method comprises contacting a reactant such as 3,4-dihydroxyphenylalanine (DOPA) with a high concentration aqueous salt solution under oxidative conditions. The resulting DM polymer may form as insoluble particles or as a coating on a substrate surface. Exemplary uses for the DM polymers include removing heavy metal ions from contaminated solutions or capturing and delivering cationic drugs such as gentamicin.
Glaxosmithkline and Northwestern University | Date: 2017-01-25
Disclosed are methods for treating cancer such as a myeloid malignancy such as multiple myeloma in a human using EZH2 inhibitors in human populations having a translocation MMSET or a decreased level of a functional UTX protein or both.
Northwestern University | Date: 2017-02-09
Disclosed are methods for preparing and screening for an inhibitor of the activity of a biological molecule having a catalytic or non-catalytic cysteine residue. The methods including preparing a library of candidate inhibitor molecules by conjugating an electrophile to a plurality of drug molecules where the library of candidate inhibitor molecules thus formed react with cysteine residues. The library of candidate inhibitor molecules then may be reacted with the biological molecule to identify those inhibitor molecule that react with the catalytic or non-catalytic cysteine residue of the biological molecule in order to identify an inhibitor of the biological molecule.
Northwestern University | Date: 2017-04-05
Motion contrast depth scanning is disclosed herein. A disclosed example apparatus includes an illumination source that is to provide at least one of spatial or temporal changes to light emitted from the illumination source to a scene. The example apparatus also includes a motion contrast sensor, where pixels of the motion contrast sensor are to detect changes corresponding to the scene, and where the motion contrast sensor is to report measurements when a pixel change exceeds a threshold. The example apparatus further includes a processor to determine at least one of a reflectance, a depth, or movement of the scene based on the reported measurements by the motion contrast sensor.