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Orange City, IA, United States

For other universities with a similar name, see Northwestern University .Northwestern College is a private Christian liberal arts college located in Orange City, Iowa. It is also known as Northwestern IA. It is affiliated with the Reformed Church in America . Northwestern began as an academy in 1882. It was then upgraded to junior college status in 1928. Then in 1961, it became the four-year institution it is today. Wikipedia.

Gusky S.,Northwestern College
American Biology Teacher | Year: 2014

In this activity, freshman college students learn biotechnology techniques while playing the role of a laboratory technician. They perform simulations of three diagnostic tests used to screen newborns for cystic fibrosis. By performing an ELISA, a PCR analysis, and a conductivity test, students learn how biotechnology techniques can be used to diagnose diseases. Students get excited when they realize they will be performing tests actually used in a real-life situation. This exercise is also appropriate for high school students. © 2014 by National Association of Biology Teachers.

Wang J.,Northwestern College | Wang J.,South Dakota State University | Li W.,South Dakota State University | Wang W.,South Dakota State University
Theoretical and Applied Genetics | Year: 2014

Key message: This research provided the first view of metabolic and physiological effect of a tissue-specific glaucousness inhibitor in wheat and laid foundation for map-based cloning of the Iw3 locus. Cuticular wax constitutes the outermost layer of plant skin, and its composition greatly impacts plant appearance and plant-environment interaction. Epicuticular wax in the upper part of adult wheat plants can form the glaucousness, which is associated with drought tolerance. In this research, we characterized a glume-specific glaucousness inhibitor, Iw3, by fine mapping, physiological, and molecular approaches. Iw3 inhibits glaucousness formation by altering wax composition. Compared to the wild type, Iw3 eliminated β-diketone, reduced 47 % primary alcohols, but increased aldehyde 400-fold and alkanes fivefold, which led to 30 % reduction of total glume wax load. Loss of the glaucousness increased cuticle permeability, suggesting an important role in drought sensitivity. Genetically, the glaucousness-inhibiting effect by Iw3 is partially dominant in a dosage-dependent manner. We localized the Iw3 locus within a 0.13-cM interval delimited by marker loci Xpsp3000 and XWL3096. Of the 53 wax genes assayed, we detected transcription changes in nine genes by Iw3, downregulation of Cer4-1 and upregulation of other five Cer4 and three KCS homologs. All these results provided initial insights into Iw3-mediated regulation of wax metabolism and paved way for in-depth characterization of the Iw3 locus and the glaucousness-related β-diketone pathway. © 2014 Springer-Verlag Berlin Heidelberg.

Wallinga M.,Northwestern College
BCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics | Year: 2015

One of the most common and most important computational biology problems is sequence alignment. Sequence alignment is the process of arranging primary sequences of DNA, RNA, or protein to identify regions of similarity in order to discover functional, structural, or evolutionary relationships between the sequences. [1] These discoveries can result in the construction of phylogenetic trees, the discovery of new protein families, the prediction of secondary or tertiary structures of new sequences, and the demonstration of homology between existing families and the newly discovered sequences. [11] The goal of sequence alignment is to find an optimum match between the sequences being investigated. This is a case of text manipulation: a DNA sequence can be represented as a character string consisting of repetitions of four characters (A, C, G, and T); a protein sequence is represented in the same way using strings built from 20 different characters. [15] To align the sequences, the character strings are positioned vertically to highlight their similarities and differences. [3] A blank space, or gap, is inserted within a sequence if its presence leads to a larger number of symbol matches. A similarity measure such as sum-of-pairs (SP) is used to quantify how well the sequences match in a given alignment; the scores of multiple candidate alignments are compared to determine an optimal alignment. [1] Pairwise sequence alignment has been solved using the dynamic programming (DP) algorithm by Needleman and Wunsch. [8] The DP technique redefines the problem as a search for the shortest path in a weighted, directed, acyclic, k-dimensional graph. Smith andWaterman published a variation of the algorithm. [13] Unfortunately, solutions for pairwise alignment are frequently too computationally expensive when they are applied to multiple sequence alignment (MSA), due the much larger size of the search space. All but the simplest multiple sequence alignment problems become computationally intractable; MSA using sum-of-pairs can be classified as NP-complete. As a result, most currently employed MSA algorithms are based on heuristics and must settle for providing a quasi-optimal alignment. [3] An alternative to multiple sequence alignment is the development of lower-complexity similarity calculations that do not require an alignment. These methods use a different metric to establish the similarity of the sequences in question. The k-mers counting method, introduced in 2002 by Katoh et al. and used in tools such as MAFFT and MUSCLE, counts the number of shared words, or k-tuples, between sequences using a compressed alphabet. This algorithm is linear, O(n), rather than exponential. [4] Copyright is held by the author/owner(s).

Adany P.,University of Kansas | Arnett D.C.,Northwestern College | Johnson C.K.,University of Kansas | Hui R.,University of Kansas
Applied Physics Letters | Year: 2011

We demonstrate a wavelength tunable optical excitation source for coherent Raman scattering (CRS) spectroscopy based on a single femtosecond fiber laser. Electrically controlled wavelength tuning of Stokes optical pulses was achieved with soliton self frequency shift in an optical fiber, and linear frequency chirping was applied to both the pump and the Stokes waves to significantly improve the spectral resolution. The coherent anti-Stokes Raman scattering (CARS) spectrum of cyclohexane was measured and vibrational resonant Raman peaks separated by 70 cm-1 were clearly resolved. Single laser-based tunable excitation may greatly simplify CRS measurements and extend the practicality of CRS microscopy. © 2011 American Institute of Physics.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ADVANCED TECH EDUCATION PROG | Award Amount: 199.96K | Year: 2014

As advanced manufacturing moves forward in the Nation, there is an increasing need to prepare a skilled, flexible, and innovative workforce. This project is developing an advanced manufacturing technician associate degree program that is designed to increase the number of skilled workers in the northwest corner of Connecticut (CT) and provide a pathway where students can pursue associate and bachelor degrees in manufacturing so they can advance their careers. The college is partnering with three school systems, the Northwest Connecticut Manufacturers Coalition (NCMC), and Regional Center for Next Generation Manufacturing (RCNGM). In addition, the college is a long-standing member of the Connecticut College of Technology (COT). As such, the college and its partners benefit from the best practices, curriculum, and articulations developed by the COT.

The project is increasing the partnerships between higher education and industry by creating a manufacturing technology program and a career pathway that can be adopted by other high schools and community colleges especially those in rural areas, and by increasing the number of high school and community college students interested in pursuing careers in manufacturing.

Surveys of the manufacturers in the northwest region helped to identify four industry-driven, workforce-based needs that are being addressed in this project:
1. Recruitment: Recruiting a skilled manufacturing workforce requires raising awareness of career possibilities within advanced technology and manufacturing fields. This project is continuing with current outreach programs to junior high and high school students to inform future skilled workers. It is also exposing unemployed, underemployed, displaced, and incumbent workers to the necessary skill sets and career possibilities of manufacturing within northwestern CT.
2. Education: A majority of manufacturers in advanced technological sectors nationwide indicate that they have a difficult time filling positions because applicants lack the necessary skills for the job. This project is developing a degree pathway that provides workers with advanced technology skills to meet workforce needs.
3. Retention: Manufacturing employers in northwestern CT have difficulty retaining employees who live outside of the area. Many employees who have the appropriate skills do not want to travel or move to rural CT and therefore end up leaving after they are trained. This project is focusing on providing people who already live in the northwest corner of the state with the skills and education they need to obtain jobs in the advanced manufacturing sector.
4. Continued education and career advancement: Modern manufacturing requires workers to keep up with technology. Incumbent workers also need skills for advancement. Both of these require a strong partnership between manufacturers and the college. This project strengthens that collaboration and provides workers with a pathway to advance their education.

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