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Martinez L.,University of Texas Health Science Center at San Antonio | Reeves A.,University of Texas Health Science Center at San Antonio | Reeves A.,Northwest Vista College | Haldenwang W.,University of Texas Health Science Center at San Antonio
Journal of Bacteriology | Year: 2010

The general stress regulon of Bacillus subtilis is controlled by σB, a transcription factor that is activated by physical or nutritional stress. In B. subtilis, each of these two stresses is communicated to the primary σB regulators by distinct pathways. Physical stress activation of σB involves a large-molecular-mass (>106-Da) structure (stressosome) formed by one or more homologous proteins (RsbRA, -B, -C, and -D) onto which the pathway's principal regulators are bound. The RsbR proteins are thought to be potential receptors for stress signaling. Listeria monocytogenes encodes orthologs of σB and its principal regulators; however, unlike B. subtilis, L. monocytogenes appears to use the stressosome pathway for both physical and nutritional stress activation of σB. In the current work, a B. subtilis strain that expressed L. monocytogenes rsbR (rsbRLm) in lieu of B. subtilis rsbR (rsbRBs) was created and was found to display the Listeria phenotype of σB activation following exposure to either physical or nutritional stress. B. subtilis expressing either the RsbR paralog rsbRC or rsbRD, but not rsbRA or rsbRB, as the sole source of RsbR also allowed σB induction following nutritional stress. It is unclear whether the nutritional stress induction seen in these strains is the result of a direct effect of nutritional stress on stressosome activity or a consequence of the background levels of σB activation in these strains and the effects of diminished ATP on the downstream phosphorylation reaction needed to reinactivate σB. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Dickinson T.L.N.,Northwest Vista College | Van Auken O.W.V.,University of Texas at San Antonio
Natural Areas Journal | Year: 2016

Bigtooth maple (Acer grandidentatum Aceraceae) is found in scattered relict populations across the southern Intermountain West of North America. The quadrat procedure was used to examine the woody plant population in a mesic site (canyon bottom near stream), a thirty-year-old deer exclosure (slightly upslope), and a xeric site (more upslope with shallower soil) at Lost Maples State Natural Area in Central Texas. All woody plants were identified, categorized as trees, saplings, or seedlings, and counted. The circumference of trees was measured. Bigtooth maple had the highest density of all seedling species, with its highest density at the mesic site and lowest in the exclosure. Both sapling and tree densities were highest in the exclosure. The mesic site did not contain bigtooth maple trees. Bigtooth maple total basal area was higher in the exclosure than at the xeric site, which had larger but fewer trees. Additionally, fifteen first-year seedlings were planted inside the exclosure and at the xeric site. One-year mortality was 100% at the xeric site and 67% in the exclosure. The presence of large vertebrate herbivores seems to affect significantly the survival and density of juvenile bigtooth maple, suggesting that browsing is a primary cause of recruitment failure in Central Texas relict populations.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ADVANCED TECH EDUCATION PROG | Award Amount: 199.22K | Year: 2012

Northwest Vista College (NVC) is implementing Project ION (Improving Opportunities in Nanotechnology) to support the educational preparation of technicians for our nations nanotechnology fields. The project is helping NVC use innovative linkages with high schools, four-year institutions, and industry partners to increase the number of technicians with current knowledge and skills entering the nanotechnology workforce. Project IONs activities are being guided by the objectives of innovation, implementation and regional adaptation. Project ION is demonstrating effective ways that two-year institutions can creatively lead partnerships with four-year institutions, research organizations, and industry partners to provide nanotechnology-related learning, research, and career development activities for STEM students. It is also creating new models for nanotechnology-focused workforce development activities for underserved populations.

Dileep K.V.,Kannur University | Kelly M.,Northwest Vista College | Hardin E.,Northwest Vista College | Sadasivan C.,Kannur University | And 2 more authors.
Journal of Cancer Science and Therapy | Year: 2013

Nanotechnology in bioscience and therapeutics has advanced tremendously in this decade. Many nanoparticle formulations as well as passive and active targeted agents have been developed and proved effective preclinically in proof-of-concept models of different cancers.Many of these formulations use polymer nanoparticles, liposomes, bubkyballs, fullerenes, carbon nanotubes, dendrimers, isotope tags, and PEG compounds. In effect, nanoparticle formulations have become the norm in chemoprevention. In this paper we review nanoformulations of bioactive compounds that have been tested for their potential mechanistic antiproliferative activity in breast cancer. We also discuss the possibility of enhancing the activity of these compounds using different innovative bioconjugation methods. © 2013 Dileep KV, et al.

Khan A.,The College of St. Scholastica | Grillo J.,Northwest Vista College
2013 ACM Conference on Bioinformatics, Computational Biology and Biomedical Informatics, ACM-BCB 2013 | Year: 2013

The state of healthcare in the United States of America is in jeopardy. Researchers have suggested the integration of technology to improve the staggering quality of care. Most urban hospitals have support in terms of finances, research, and professional services whereas the rural hospitals are required to accomplish the integration of technology with little means to support and monitor the process. This study examined the quality of care in rural critical access hospitals with the maintaining of an up-to-date problem list. Copyright © 2007 by the Association for Computing Machinery.

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