Newcastle upon Tyne, United Kingdom
Newcastle upon Tyne, United Kingdom

Northumbria University, officially the University of Northumbria at Newcastle, is a university located in Newcastle upon Tyne in the North East of England. A former polytechnic, it was established as one of the new universities in 1992. It is a member of the University Alliance. It is the second university of Newcastle, along with Newcastle University. Wikipedia.

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Patent
Northumbria University | Date: 2015-02-16

The invention provides a method of producing a synthetic retina, comprising: i) providing a three dimensional stem cell culture throughout the differentiation time course, ii) differentiating the three dimensional stem cell culture for a first time period in a first neural cell culture medium comprising: a) L-glutamine; b) B27 supplement; and c) an IGF-1 receptor agonist, iii) subsequently differentiating the three dimensional stem cell culture for a second time period in a second neural cell culture medium comprising: a) L-glutamine; b) B27 supplement; c) N2 supplement; and d) an IGF-1 receptor agonist, wherein said synthetic retina contains laminated retinal tissue comprising.


Patent
Northumbria University | Date: 2015-09-30

A method of manufacturing a compressed coil and a system for holding a wire during the manufacture of a compressed coil are disclosed. The method includes providing a wire including a first lead section, a central section and a second lead section. The central section of the wire is wound around a bobbin to form a coil. A punch top is located over an end of the bobbin such that the end of the bobbin is located at least partially within a through-hole of the punch top. A second lead section of the wire is located within a groove in an outer surface of the punch top or bobbin and pressure is applied to the bobbin and/or punch top to compress the coil.


Patent
Northumbria University | Date: 2017-08-09

A method of manufacturing a compressed coil and a system for holding a wire during the manufacture of a compressed coil are disclosed. The method includes providing a wire including a first lead section, a central section and a second lead section. The central section of the wire is wound around a bobbin to form a coil. A punch top is located over an end of the bobbin such that the end of the bobbin is located at least partially within a through-hole of the punch top. A second lead section of the wire is located within a groove in an outer surface of the punch top or bobbin and pressure is applied to the bobbin and/or punch top to compress the coil.


Patent
University of Michigan and Northumbria University | Date: 2017-04-05

The present disclosure relates to compositions and methods for destabilizing biofilms, altering biofilm 3D structure, and dispersing biofilms, in order to enhance biofilm cell removal and/or sensitivity to other agents (e.g., environmental or co-applied treatments). In particular, the present disclosure relates to the use of L-arginine in the removal and/or sensitization (e.g., to antimicrobials) of microorganisms in medical, industrial, domestic, or environmental applications, as well as treatment of bacterial infections (e.g., in biofilms).


An optrode arrangement for delivering optical stimulation to target tissue in a patient, the optrode arrangement comprising an implantable optrode comprising at least one electrically powered light emitter and an electrical circuit and control lines for controlling the light emitter, whereby an associated controller has two modes of operation: a stimulation mode in which it is configured to control the light emitter to deliver optical stimulation to the target tissue and a diagnostic mode in which it is configured to determine a condition of the light emitter and/or the optrode.


Patent
University of Leicester, Northumbria University and IMPERIAL INNOVATIONS Ltd | Date: 2015-01-29

The invention provides a two-step approach to providing a BCI system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (ADC) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step. In the second step the low-power implantable platform amplifies and filters the extracellular recording, performs ADC and detects action potentials, which can be matched on-chip to the predetermined templates generated by the external receiver in the first step. This two-step approach exploits the advantages of both offline and online processing, providing an effective and safe method for performing multiple recordings of single-neuron activity, for research or monitoring applications or for control of a remote device.


An optrode arrangement for delivering optical stimulation to target tissue in a patient, the optrode arrangement comprising an implantable optrode comprising at least one electrically powered light emitter and an electrical circuit and control lines for controlling the light emitter, whereby an associated controller has two modes of operation: a stimulation mode in which it is configured to control the light emitter to deliver optical stimulation to the target tissue and a diagnostic mode in which it is configured to determine a condition of the light emitter and/or the optrode.


Patent
Northumbria University | Date: 2017-03-01

The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention has applications in use as a natural food colouring, as antioxidants in the food supplement industries, in the nutraceutical, pharmaceutical, and cosmeceutical industries, and a non-toxic ink. The method results in pigment that is relatively easy to separate from the microorganism culture.


Perkins N.D.,Northumbria University
Nature Reviews Cancer | Year: 2012

It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-κB activation, it is now becoming clear that the inhibitor of NF-κB kinases (IKKs), which regulate NF-κB activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-κB subunits. © 2012 Macmillan Publishers Limited. All rights reserved.


Curtin N.J.,Northumbria University
Nature Reviews Cancer | Year: 2012

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the DNA damage response (DDR), is associated with a predisposition to cancer and affects responses to DNA-damaging anticancer therapy. Dysfunction of one DNA repair pathway may be compensated for by the function of another compensatory DDR pathway, which may be increased and contribute to resistance to DNA-damaging chemotherapy and radiotherapy. Therefore, DDR pathways make an ideal target for therapeutic intervention; first, to prevent or reverse therapy resistance; and second, using a synthetic lethal approach to specifically kill cancer cells that are dependent on a compensatory DNA repair pathway for survival in the context of cancer-associated oxidative and replicative stress. These hypotheses are currently being tested in the laboratory and are being translated into clinical studies. © 2012 Macmillan Publishers Limited. All rights reserved.

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