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Li Y.,Guizhou University | Lu P.,Guizhou University | Hu D.,Guizhou University | Bhadury P.S.,NorthernChem Inc. | And 2 more authors.
Journal of AOAC International | Year: 2015

A rapid and accurate LC/MS/MS method using positive electrospray ionization was established for the determination of residues of the novel plant antiviral agent dufulin in samples of tobacco leaf (dry), tomato, cucumber, and rice. Samples were extracted with acetonitrile; cleaned up by dispersive SPE using primary secondary amine, C18, and graphitized carbon black sorbents; separated on a C18 column; and confirmed by multiple reaction monitoring mode MS with a matrix effect of-21.5-19.6%. The method showed satisfactory linearity (R2 ≥0.9912) for the target compound. The LOD and the LOQ were 0.05 and 0.15 μg/kg, respectively. The mean recoveries from four matrixes varied from 71.9 to 93.6% with intraday RSD in the range of 2.9 to 9.0% and interday RSD 6.9 to 15.2%. The method was successfully applied for analysis of dufulin in actual trial samples.

Li H.,Guizhou University | Li H.,Technical University of Denmark | Bhadury P.S.,NorthernChem Inc. | Riisager A.,Technical University of Denmark | Yang S.,Guizhou University
Catalysis Science and Technology | Year: 2014

Much attention has been focused on the efficient transformations of renewable lignocellulosic biomass, particularly polysaccharides, to valuable chemicals and biofuels in the past decade. One strategy to produce chemicals from biomass in a more sustainable way is to integrate various types of catalytic process in a single pot. In contrast to multiple catalytic processes with separate reaction steps, the one-pot integration of sequential catalytic processes can maximize efficiency, minimize waste and increase profitability in the multistep transformation of biomass. The present article aims to review recent research progress towards the reasonable integration of sequential catalytic processes, to achieve the end goal of comprehensive utilization of biomass in both the chemical industry and academia. The systems described in this article mainly involve those using polysaccharides as the substrates and the coupling of different chemical/biological reactions in a single pot. © 2014 the Partner Organisations.

Bhadury P.S.,NorthernChem Inc | Pang J.,NorthernChem Inc
Current Organic Chemistry | Year: 2014

The indole network has been identified as an important pharmacophore of several natural products and synthetically prepared molecules. Asymmetric organocatalytic Friedel-Crafts alkylations of electron rich indoles are of enormous significance for the synthesis of many bioactive compounds, natural products and anti-cancer drugs. Chiral BrØnsted acid-catalyzed Friedel-Crafts-type reactions of indole and its derivatives with various carbon-centered electrophiles e.g. electron deficient olefins, carbonyls, imines and some substituted methanamines and carbinols have been employed to prepare optically active indole derivatives. These reactions, their stereochemical outcome and probable modes of activation of the substrates by suitably substituted axially dissymmetric BINOL-derived chiral BrØnsted acid catalysts are discussed in this review. © 2014 Bentham Science Publishers.

Zhao M.,Shanghai University of Engineering Science | Zhang X.,Shanghai University of Engineering Science | He C.,Shanghai University of Engineering Science | Bhadury P.S.,Northernchem Inc. | Sun Z.,Shanghai University of Engineering Science
Australian Journal of Chemistry | Year: 2015

The Friedel-Crafts reaction of indoles with a wide range of α,β-unsaturated aldimines catalysed by binaphthyl phosphoric acid is demonstrated. The resulting tris(indolyl)propanes are presumably generated by a concerted 1,2- and 1,4-nucleophilic attack to the conjugated imines. According to the preliminary bioassay results, the compound 4e exhibits moderate activity against pancreatic cancer cells. © 2015 CSIRO.

Bhadury P.S.,NorthernChem Inc | Pang J.,NorthernChem Inc
Current Organic Chemistry | Year: 2015

Despite incredible advancement made in recent years, treatment of cancer still remains the most challenging task for the mankind. The new small molecule therapeutic drugs are more specific, exhibit better therapeutic efficacy and mostly contain scaffolds of [1]-lactam, sulfonamide, quinoline, quinazoline, quinoxaline, purine, pyrimidine, resorcinol, pyrazole/isoxazole, benzamide etc. The structure-activity relationships of different pharmacophores that have been reported to potently inhibit cell growth of human tumour cell lines are constantly being investigated. Development of products of natural origin can also prove effective without submitting to harmful radiation and chemotherapy treatments. Under these circumstances, the practicing organic chemists are greatly facing the challenge of designing new and leading anti-cancer drugs based on natural products and scaffolds of potent pharmacaophores. The review intends to cover new approach of anti-cancer drug design using natural and synthetic pharmacophores. The plausible synthetic routes to major drugs for oncology that were approved recently by Food and Drug Administration (FDA) are also discussed. © 2015 Bentham Science Publishers.

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