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Northeastern University is a private nonprofit research university located in Boston, Massachusetts. The university features a range of undergraduate and graduate programs leading to degrees through the doctorate in nine colleges and schools, as well as advanced degrees at graduate campuses in Charlotte, North Carolina, and Seattle, Washington.Northeastern's main campus is located in the Fenway, Roxbury, South End, and Back Bay neighborhoods. The university has roughly 16,000 undergraduates and almost 8,000 graduate students. Northeastern is categorized as a RU/H Research University by the Carnegie Classification of Institutions of Higher Education. In 2011, Northeastern opened the George J. Kostas Research Institute for Homeland Security.Northeastern features a cooperative education program that integrates classroom study with professional experience on seven continents. In 2012-2013, 7,968 students participated in the co-op program.The Northeastern University Huskies compete in the NCAA Division I as members of Colonial Athletic Association in 18 varsity sports offered by the CAA. The men's and women's hockey teams compete in Hockey East, while the men's and women's rowing teams compete in the Eastern Association of Rowing Colleges and Eastern Association of Women's Rowing Colleges , respectively. In 2013, men's basketball won its first CAA regular season championship, men's soccer won the CAA title for the first time, and women's ice hockey won a record 16th Beanpot championship. Wikipedia.

Wanunu M.,Northeastern University
Physics of Life Reviews | Year: 2012

Much more than ever, nucleic acids are recognized as key building blocks in many of life's processes, and the science of studying these molecular wonders at the single-molecule level is thriving. A new method of doing so has been introduced in the mid 1990's. This method is exceedingly simple: a nanoscale pore that spans across an impermeable thin membrane is placed between two chambers that contain an electrolyte, and voltage is applied across the membrane using two electrodes. These conditions lead to a steady stream of ion flow across the pore. Nucleic acid molecules in solution can be driven through the pore, and structural features of the biomolecules are observed as measurable changes in the trans-membrane ion current. In essence, a nanopore is a high-throughput ion microscope and a single-molecule force apparatus. Nanopores are taking center stage as a tool that promises to read a DNA sequence, and this promise has resulted in overwhelming academic, industrial, and national interest. Regardless of the fate of future nanopore applications, in the process of this 16-year-long exploration, many studies have validated the indispensability of nanopores in the toolkit of single-molecule biophysics. This review surveys past and current studies related to nucleic acid biophysics, and will hopefully provoke a discussion of immediate and future prospects for the field. © 2012 Elsevier B.V.

Torchilin V.P.,Northeastern University | Torchilin V.P.,King Abdulaziz University
Nature Reviews Drug Discovery | Year: 2014

The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in vivo effectiveness of drugs is now well established. The development of multifunctional and stimulus-sensitive NDDSs is an active area of current research. Such NDDSs can have long circulation times, target the site of the disease and enhance the intracellular delivery of a drug. This type of NDDS can also respond to local stimuli that are characteristic of the pathological site by, for example, releasing an entrapped drug or shedding a protective coating, thus facilitating the interaction between drug-loaded nanocarriers and target cells or tissues. In addition, imaging contrast moieties can be attached to these carriers to track their real-time biodistribution and accumulation in target cells or tissues. Here, I highlight recent developments with multifunctional and stimuli-sensitive NDDSs and their therapeutic potential for diseases including cancer, cardiovascular diseases and infectious diseases. © 2014 Macmillan Publishers Limited.

Vespignani A.,Northeastern University | Vespignani A.,Institute for Scientific Interchange ISI
Nature Physics | Year: 2012

In recent years the increasing availability of computer power and informatics tools has enabled the gathering of reliable data quantifying the complexity of socio-technical systems. Data-driven computational models have emerged as appropriate tools to tackle the study of dynamical phenomena as diverse as epidemic outbreaks, information spreading and Internet packet routing. These models aim at providing a rationale for understanding the emerging tipping points and nonlinear properties that often underpin the most interesting characteristics of socio-technical systems. Here, using diffusion and contagion phenomena as prototypical examples, we review some of the recent progress in modelling dynamical processes that integrates the complex features and heterogeneities of real-world systems.

Staphylococcus aureus is an opportunistic pathogen capable of causing a variety of diseases including osteomyelitis, endocarditis, infections of indwelling devices and wound infections. These infections are often chronic and highly recalcitrant to antibiotic treatment. Persister cells appear to be central to this recalcitrance. A multitude of factors contribute to S. aureus virulence and high levels of treatment failure. These include its ability to colonize the skin and nares of the host, its ability to evade the host immune system and its development of resistance to a variety of antibiotics. Less understood is the phenomenon of persister cells and their role in S. aureus infections and treatment outcome. Persister cells occur as a sub-population of phenotypic variants that are tolerant to antibiotic treatment. This review examines the importance of persisters in chronic and relapsing S. aureus infections and proposes methods for their eradication. © 2014 WILEY Periodicals, Inc.

Abraham K.M.,Northeastern University
Journal of Physical Chemistry Letters | Year: 2015

Energy densities of Li ion batteries, limited by the capacities of cathode materials, must increase by a factor of 2 or more to give all-electric automobiles a 300 mile driving range on a single charge. Battery chemical couples with very low equivalent weights have to be sought to produce such batteries. Advanced Li ion batteries may not be able to meet this challenge in the near term. The state-of-the-art of Li ion batteries is discussed, and the challenges of developing ultrahigh energy density rechargeable batteries are identified. Examples of ultrahigh energy density battery chemical couples include Li/O2, Li/S, Li/metal halide, and Li/metal oxide systems. Future efforts are also expected to involve all-solid-state batteries with performance similar to their liquid electrolyte counterparts, biodegradable batteries to address environmental challenges, and low-cost long cycle-life batteries for large-scale energy storage. Ultimately, energy densities of electrochemical energy storage systems are limited by chemistry constraints. © 2015 American Chemical Society.

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