Northeastern University is a private nonprofit research university located in Boston, Massachusetts. The university features a range of undergraduate and graduate programs leading to degrees through the doctorate in nine colleges and schools, as well as advanced degrees at graduate campuses in Charlotte, North Carolina, and Seattle, Washington.Northeastern's main campus is located in the Fenway, Roxbury, South End, and Back Bay neighborhoods. The university has roughly 16,000 undergraduates and almost 8,000 graduate students. Northeastern is categorized as a RU/H Research University by the Carnegie Classification of Institutions of Higher Education. In 2011, Northeastern opened the George J. Kostas Research Institute for Homeland Security.Northeastern features a cooperative education program that integrates classroom study with professional experience on seven continents. In 2012-2013, 7,968 students participated in the co-op program.The Northeastern University Huskies compete in the NCAA Division I as members of Colonial Athletic Association in 18 varsity sports offered by the CAA. The men's and women's hockey teams compete in Hockey East, while the men's and women's rowing teams compete in the Eastern Association of Rowing Colleges and Eastern Association of Women's Rowing Colleges , respectively. In 2013, men's basketball won its first CAA regular season championship, men's soccer won the CAA title for the first time, and women's ice hockey won a record 16th Beanpot championship. Wikipedia.
Northeastern University | Date: 2017-02-15
Disclosed herein are systems and methods to detect and manage information leaks resulting from network flows generated responsive to user interaction with a computing device(105). For example, an information leak control system (110) may be configured to generate an information leak model using at least one labeled network flow comprising at least one labeled information leak, detect an information leak of a device network flow of at least one device based on the information leak model, receive user feedback associated with the information leak, and update the model based on the user feedback. In addition, the information leak control system may be configured to present information leaks to users via a graphical user interface (130) configured to allow users to provide the user feedback. In some examples, the information leak control system may be configured to modify the device network flow based on the information leak and/or the user feedback.
Northeastern University, Dana-Farber Cancer Institute, Brigham and Women's Hospital | Date: 2017-05-31
A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.
Northeastern University | Date: 2017-04-12
A method and apparatus for producing a composite part are provided to enable composite parts to be assembled with precise control over the orientation and spatial distribution of reinforcing or other particles within a matrix material. The method and apparatus use magnetic fields applied during various additive manufacturing processes to achieve complex particles orientations within each layer of the part. The composite parts can achieve enhanced properties, including mechanical, thermal, electrical and optical properties.
Northeastern University | Date: 2017-04-19
The invention provides a cathode material for Ll-ion batteries. The material has the formula of 0.5Li2Mn03-0.5LiMn0.5Ni0.35Co0.1502. The material was synthesized using the self-ignition combustion method, which previously has not been used for the preparation of Li-rich layered metal oxides. The cathode material exhibits capacities of 290, 250, and 200 mAh/g at discharge rates of C/20, C/4 and C rates, respectively. Moreover, the new material exhibits high rate cycling ability with little or no capacity fade for over 100 cycles demonstrated at a series of rates from C/20 to 2C rates for electrodes loadings of 7-8 mg/cm2.
Northeastern University | Date: 2017-05-03
A microfluidic device provides high throughput generation and analysis of defined three-dimensional cell spheroids with controlled geometry, size, and cell composition. The cell spheroids of the invention mimic tumor microenvironments, including pathophysiological gradients, cell composition, and heterogeneity of the tumor mass mimicking the resistance to drug penetration providing more realistic drug response. The device is used to test the effects of antitumor agents.
Northeastern University | Date: 2017-02-01
A system and method for providing multivariate climate change forecasting are provided that obtain, from one or more climate model datasets, simulated historical and future climate model data, and from one or more climate observational datasets, historical observed climate data. A statistical distribution, using a Bayesian model, is provided of extremes or climate indices for one or more variable climate features using the simulated climate model data and the observed climate data. One or more metrics are determined, including a prediction of a future climate variable for a determined future time period, a confidence bound of the prediction of the future climate variable for the determined future time period, and a prediction bound for the future climate variable for the determined future time period. The metrics can be transmitted to a variety of applications in a variety of formats.
Northeastern University | Date: 2017-05-17
Nanoparticulate carrier formulations are useful to solubilize, deliver, and target hydrophobic drugs for treating diseases including cancer and bacterial infections. The formulations contain amphiphilic peptides having a hydrophobic portion and a positively charged hydrophilic portion. The peptides self-associate at nonacidic pH to form micelles with a spherical nanoparticle morphology. The hydrophobic core of the nanoparticles encapsulates hydrophobic drugs, including antitumor agents, increasing their solubility in water and allowing them to be targeted, for example, to cancer cells. The positively charged surface of the nanoparticles, together with an optional targeting moiety such as an RGD peptide, allows the nanoparticles to bind selectively to mammalian cells and bacterial cells, including cancer cells that overexpress integrin receptors. The pH-dependence of the nanoparticle association/dissociation can be employed to conveniently load the nanoparticles with hydrophobic drug using a controlled pH shift, and unload them in acidic intracellular compartments. The ability of the carrier formulations to solubilize and target hydrophobic drugs gives rise to strategies for the selective inhibition or killing of cancer cells, such as the killing of osteosarcoma cells using the drug curcumin. The amphiphilic peptides and nanoparticles derived therefrom also give rise to additional compositions and methods that have useful bacteriocidal features as well as the ability to promote cell adhesion in cell scaffolds and coatings for medical implants.
Northeastern University | Date: 2017-02-22
A monolithic integration of phase change material (PCM) switches with a MEMS resonator is provided to implement switching and reconfiguration functionalities. MEMS resonator includes a piezoelectric material to control terminal connections to the electrodes. The PCM is operable between an ON state and an OFF state by application of heat, which causes the phase change material to change from an amorphous state to a crystalline state or from a crystalline state to an amorphous state, the amorphous state and the crystalline state each associated with one of the ON state and the OFF state. A method of fabricating the MEMS resonator with phase change material is provided. A reconfigurable filter system using the MEMS resonators is also provided.
Tilly, Woods and Northeastern University | Date: 2017-02-01
The present technology provides for methods for generation and isolation of granulosa cells and/or granulosa cell precursors from multi-potent cells, wherein the granulosa cells and/or granulosa cell precursors are useful in methods for growth and maturation of follicles or follicle-like structures. Additionally, the present technology also provides for methods of increasing steroidal hormones in a subject in need thereof.
Northeastern University | Date: 2017-01-06
The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.