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Corrientes, Argentina

The National University of the Northeast is an Argentine national university. It is located in the cities of Corrientes and Resistencia, capitals cities of the Provinces of Corrientes and Chaco respectively, and was established on December 4, 1956. Known as the university of the sun, it is the seventh-largest university in Argentina by student enrollment numbers. Wikipedia.

Candia O.A.,Mount Sinai School of Medicine | Mathias R.,State University of New York at Stony Brook | Gerometta R.,Northeast National University
Investigative Ophthalmology and Visual Science | Year: 2012

PURPOSE. In 1997, a theoretical model was developed that predicted the existence of an internal, Na{thorn}-driven fluid circulation from the poles to the equator of the lens. In the present work, we demonstrate with a novel system that fluid movement can be measured across the polar and equatorial surface areas of isolated cow lenses. We have also determined the effects of ouabain and reduced bath [Na+]. METHODS. Lenses were isolated in a chamber with three compartments separated by two thin O-rings. Each compartment, anterior (A), equatorial (E), and posterior (P), was connected to a vertical capillary graduated in 0.25 μL. Capillary levels were read every 15 minutes. The protocols consisted of 2 hours in either open circuit or short circuit. The effects of ouabain and low-Na{thorn} solutions were determined under open circuit. RESULTS. In 21 experiments, the E capillary increased at a mean rate of 0.060 μL/min while the A and P levels decreased at rates of 0.044 and 0.037 μL/min, respectively, closely accounting for the increase in E. The first-hour flows under short circuit were approximately 40% larger than those in open-circuit conditions. The first-hour flows were always larger than those during the second hour. Preincubation of lenses with either ouabain or low-[Na{thorn}] solutions resulted in reduced rates of fluid transport. When KCl was used to replace NaCl, a transitory stimulation of fluid transport occurred. CONCLUSIONS. These experiments support that a fluid circulation consistent with the 1997 model is physiologically active. © 2012 The Association for Research in Vision and Ophthalmology, Inc.

Pays J.-F.,Northeast National University
Bulletin de la Societe de Pathologie Exotique | Year: 2011

Infection of carriers of strongyloides by the human oncogenic retrovirus HTLV-1 significantly augments the number of larval parasites in the stools and impairs the action of anti-helminthic agents, resulting in an increase in immediate and longer term failure of therapy. The proliferation of cytokine type 1 secreting lymphocytes, the preferred target for viral infection, shifts the Th1/Th2 balance in favour of a Th1 response with a consequent increase in the production of gamma interferon (INF-γ). In addition to other effects, this causes a decrease in the secretion of cytokines IL-4, IL-5 and IL-13, which results in substantial reduction in total and specific IgE; failure of activation of eosinophils or stagnation in or reduction of their numbers; and an increased risk of development of a severe form of strongyloidiasis. This risk is clearly correlated with the level of anti-HTLV-1 antibodies and the amplitude of the proviral load of peripheral lymphocytes. The polyclonal expansion of infected CD4 cells might be partly due to the activation of the IL-2/IL-2R system by parasite antigens together with the action of the virus type 1 Tax protein. The fact that adult T cell leukaemia arises significantly earlier and more often in individuals with combined infection is an argument in favour of the parasite's role as a leukaemogenic co-factor. In practice it is, therefore, appropriate to initiate all available measures to eliminate parasites from co-infected hosts although this does present difficulties, and one should not reject the possibility of a diagnosis of strongyloidiasis in the absence of hypereosinophilia. In all cases of chronic strongyloidiasis without hypereosinophilia, co-infection with HTLV-1 should be looked for routinely. The same applies to carriers of strongyloides with repeated treatment failures. Finally, corticosteroids and immunosuppressants should be used only with care in HTLV-1-positive patients who seem not to be co-infected, even if they have received precautionary therapy. © Société de pathologie exotique et Springer-Verlag France 2011.

Canteros M.G.,Northeast National University
Drug Discovery Today | Year: 2014

In humans, as in other mammals, endogenous glucocorticoids (GCs) are essential for adapting to physiological life stress. They are also crucial for the healthy development of the fetus. However, when the physiological concentrations of GCs increase over a long period of time, the central nervous system (CNS) is predisposed to the development of psychiatric disorders and neurological diseases. Here, I discuss the strong influence of GCs on the nitric oxide (NO) pathway and the generation of reactive oxygen species (ROS). I also highlight supporting evidence for the neuroprotective actions of d-arginine (d-Arg) against neurotoxicity induced by high levels of GCs in the CNS. Given that d-Arg does not interfere with the immunosuppressive and anti-inflammatory effects of GCs, this might be a novel way of neutralizing the neurotoxic effects of GCs in the CNS without compromising their positive peripheral actions. © 2013 Elsevier Ltd.

Cardozo O.D.,Northeast National University | Garcia-Palomares J.C.,Complutense University of Madrid | Gutierrez J.,Complutense University of Madrid
Applied Geography | Year: 2012

In recent years, station-level ridership forecasting models have been developed based on Geographic Information Systems (GIS) and multiple regression analysis. These models estimate the number of passengers boarding at each station as a function of the station characteristics and the areas that they serve. These models have considerable advantages over the traditional four-step model, including simplicity of use, easy interpretation of results, immediate response and low cost. Nevertheless, the models usually use traditional ordinary least squares (OLS) multiple regression, which assume parametric stability. This study proposes a direct model that uses geographically weighted regression (GWR) to forecast boarding at the Madrid Metro stations. Here, the results obtained using the OLS and GWR models are compared. The GWR model results in a better fit than the traditional one. In addition, the information supplied by the GWR model regarding the spatial variation of elasticities and their statistical significance provides more realistic and useful results. © 2012 Elsevier Ltd.

Lobayan R.M.,Northeast National University
Chemical Physics Letters | Year: 2013

We present a theoretical description of the case of the strained [1.1.1]propellane system by application of the local and nonlocal topological formalisms to the density decomposition into its effectively paired and unpaired contributions. The analysis is mainly focused on the nature of its carbon-carbon headbridge sequence and the existence of 2e-3c complex patterns of bonding. The results clearly indicate that the system only possess 2e-2c patterns, including a true carbon-carbon headbridge bond and no 3c-2e complex patterns of bonding appear. © 2012 Elsevier B.V. All rights reserved.

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