Vaalmazov North Western Federal Medical Research Center

St.Petersburg, Russia

Vaalmazov North Western Federal Medical Research Center

St.Petersburg, Russia
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Gurova M.M.,Belgorod State University | Novikova V.P.,Vaalmazov North Western Federal Medical Research Center
Voprosy Prakticheskoi Pediatrii | Year: 2017

The objective. To study the trace element status in children with chronic gastroduodenitis at different phases of disease and its interrelations with specific states of other homeostatic systems of the body. Patients and methods. The article evaluates the trace element homeostasis, parameters of oxidant and antioxidant status, intestinal microbiota in children with chronic gastroduodenitis (CGD), associated with Helicobacter pylori infection, in the exacerbation phase and 6 months after successful eradication therapy. Results. The trace element homeostasis in children with CGD in exacerbation was characterised by significant shifts persisting in the remission phase. Exacerbation was characterised by not only higher concentrations of toxic trace elements (arsenic, nickel, mercury, lead), but also a significant decrease of vital trace elements (copper, manganese, selenium, zinc, iron). These changes positively correlated with the severity of inflammatory changes in gastric and duodenal mucosa. Remission was marked by normalisation of the levels of toxic trace elements along with persisting copper, selenium, and iron deficiencies. These shifts were accompanied by decreased amounts of the normal flora, in 1/3 of cases overgrowth of enterococci and in 25% of cases - of Candida spp. above 1000 CFU/g was detected, which could attribute this condition to Candida dysbiosis of the large intestine. Against the background of clinical remission of CGD 6 months after administration of a standard eradication regimen permanent endoecological disorders remained as reduced representation of the normal flora (bifidobacteria and lactobacilli), persisting overgrowth of conditionally pathogenic bacteria and Candida dysbiosis in 30% of children. Conclusion. The above changes of the trace element homeostasis and other basic regulatory systems necessitate using drugs from the sorbent group in complex therapy of chronic disorders of the upper gastrointestinal tract in both exacerbation and remission phases. © 2017, Dynasty Publishing House. All rights reserved.


Novikova V.P.,Vaalmazov North Western Federal Medical Research Center | Kosenkova T.V.,Vaalmazov North Western Federal Medical Research Center | Turganova E.A.,Vaalmazov North Western Federal Medical Research Center | Listopadova A.P.,Consultative Diagnostic Center with ily Clinic
Voprosy Detskoi Dietologii | Year: 2017

Environmental pollution occurring in many regions of Russia through impact of eco-pollutants on a child's respiratory tract results in the change of the trace element composition of the body due to accumulation of salts of heavy metals, which might be not only factors of BA development but also trigger exacerbation of disease or compromise its course. The objective. To study the levels of trace elements in hair of children suffering from bronchial asthma. Patients and methods. In all, we examined 20 adolescents (10 - adolescents suffering from moderate BA, 10 - control group). The chemical analysis of hair with detection of 33 elements was performed by the method of inductively coupled plasma mass spectrometry. Results. The study showed that in the hair of children with BA higher levels of the main ecotoxicants - barium and lead - were found as compared with healthy children. Conclusion. These results permit to recommend the use of enterosorbents to reduce the impact of anthropogenic factors on children with BA.

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