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Troitskiy, Russia

Sidorov P.I.,North State Medical University
Human Ecology | Year: 2014

In the article, there have been separated factors and tendencies of changes of mental ecology in the modern world, augmentation of anomia and permissiveness, deformation of personality and social identity leading to wider and uncontrolled reproduction of social troubles and dependent disorders creating a threat to national security in the form of social epidemies. There have been described the structure and fractal ontogenetic dynamics of the demoralization syndrome. There has been grounded the synergetic approach to organization of an effective response in the form of development of a pilot model of systemic monitoring and a mental health service allowing to provide new quality of medico-psycho-socio-spiritual defense of the nation's mental health and treatment of mental illnesses. Source

Sidorchuk A.,Karolinska Institutet | Sidorchuk A.,North State Medical University | Hemmingsson T.,Karolinska Institutet | Romelsjo A.,Karolinska Institutet | Allebeck P.,Karolinska Institutet
PLoS ONE | Year: 2012

Background: The role of alcohol consumption for disability pension (DP) is controversial and systematic reviews have not established causality. We aimed to assess the role of adolescent alcohol use for future DP. We wanted to find out whether an increased risk mainly would affect DP occurring early or late in life as well as whether the level of alcohol consumption and patterns of drinking contribute differently in DP receiving. Methodology/Principal Findings: The study is a 39-year follow-up of 49 321 Swedish men born in 1949-1951 and conscripted for compulsory military service in 1969-1970. As study exposures (i) "risk use" of alcohol composed of measures related to pattern of drinking, and (ii) the level of consumption based on self-reported volume and frequency of drinking had been used. Information on DP was obtained from social insurance databases through 2008. "Risk use" of alcohol was associated with both "early DP" and "late DP", i.e. granted below and above the approximate age of 40 years, with crude hazard ratio (HR) of 2.89 (95% confidence intervals (CI) 2.47-3.38) and HR of 1.87 (95%CI: 1.74-2.02), respectively. After adjustment for covariates, HR was reduced to 1.32 (95%CI: 1.09-1.59) and 1.14 (95%CI: 1.05-1.25), respectively. Similar patterns were seen for moderate (101-250 g 100% alcohol/week) and high (>250 g) consumption, though the risk disappeared when fully adjusted. Conclusions/Significance: Alcohol use in adolescence, particularly measured as "risk use", is associated with increased risk of future DP. The association is stronger for "early DP", but remains significant even for DP granted in older ages. Therefore, pattern of drinking in adolescent should be considered an important marker for future reduced work capacity. © 2012 Sidorchuk et al. Source

Aim. To comparatively evaluate the hepatoprotective activity of reamberine, remaxol, and exogenous ademethionine and a risk for unfavorable/favorable outcomes of their use in patients with liver injury during antituberculosis chemotherapy. Subjects and methods. One hundred and eighty patients with new-onset respiratory tuberculosis were examined and divided into 4 groups (45 patients in each group): Study Croup 1 (SG1): patients who took reamberine; Study Group 2 (SG2): those who received remaxol; Study Group 3 (SG3): those who had ademethionine; and a Comparative Group (CG): those who received 5% glucose solution. The test drugs were intravenously administered in a dropwise manner once daily for 10 days. The laboratory hepatic injury severity index (LHISI) was estimated according to the method described by T.N. Kalachnyuk and the risk for a favorable/unfavorable outcome was assessed, by calculating the average cost of the used hepatotropic agents. Results. LHISI increased statistically significantly with the development of liver Injury induced by antituberculosis agents. There was a statistically significant reduction in LHISI during therapy with the test hepatotropic agents versus glucose solution, the most pronounced activity being shown by remaxol. Relative risk (RR) and odds ratio (OR) assessments revealed the high likelihood of a favorable outcome (a reduction in LHISI) when each of the 3 test drugs versus glucose solution was administered; the highest RR and OR were also found in the use of remaxol. Estimation of costs and the number of patients to be treated (NPBT) in order to avoid a case of none LHLIS reduction could reveal the highest efficacy of remaxol. Conclusion. The test agents (reamberine, remaxol, and ademethionine) are effective in treating tuberculosis patients with druginduced liver injury. The administration of remaxol demonstrated the highest positive effect (as estimated by LHISI) in terms of both RR and NPBT. Source

Zheglova M.,North State Medical University
Genes and Cells | Year: 2014

The aim of the research was to give the morphofunctional characteristics of embryonic histogenesis of the female genital tract abortuses. We have studied 50 abortuses at the age of 4-12 weeks of gestation. The fixation of material and of the sample preparations were carried out according to the principles of quantitative histochemistry. According to the data obtained, paramesonefric ducts are found in the composition of the urogenital blastema to which coelomic epithelium cells can migrate. Since in this time the more differentiated ducts are mesonefric and archinephron is the organ that carries out its function, it is undeniable that the development of paramesonefric ducts goes on vector of the cranio-caudal growth of mesonefric ducts. The formation of a common utero-vaginal canal occurs through the convergence of the paramesonefric duct walls. Herewith the septum between ducts is persisted. Epitheliocytes in the medial walls of the ducts are deformed, nuclei decrease in size. The shape of the nuclei changes and rectangular nuclei dominate. The cells which have a light nucleoplasm are detected, in other cells there is a piknotic nucleus in the center; there are cells with nuclei having the semilunar shape, cells with two fragments of the nucleus, one of which is dark and the other one is light; nucleus with cuspidal protrusions at one pole, cigar-shaped nucleus. The formation of the complex relationships between the paramesonefric ducts at the entrance into mesenchymal block allows to make a suggestion on the critical period of the female genital tract development. Source

Pechersky A.,North State Medical University
Central European Journal of Urology | Year: 2014

Introduction Decreasing of testosterone level is an important part of a male elderly.Material and methods To describe this phenomenon a PubMed and national databases were searched for 17β-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men.Results The reduction in intensity of the processes of tissue renewal of the testicles results in a partial androgen deficiency of aging men. A decrease in the levels of total and free testosterone and an increase in the levels of 5α-dihydrotestosterone, 17β-estradiol, sex hormone binding globulin, LH and FSH, along with a decrease in the amplitude of the rhythm of incretion of LH, FSH and total testosterone will testify to a deficiency of testosterone.Conclusions It is very important to make an individualized selection of the dose of testosterone preparation which enters the blood plasma. Key Words 5α-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men © 2014 Polish Urological Association. All rights reserved. Source

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