Troitskiy, Russia

North State Medical University
Troitskiy, Russia
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The article provides comments on 2016 American College of Cardiology Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk. The reasons for publishing this document are discussed, in particular appearance of results of conducted during last 3 years clinical trials of new highly effective non-statin medications. The article contains descriptions of indications, contraindications to the use of these agents as of their possible side effects. The preferred order of their administration in combination with statins in different categories of patients is also presented.

Garkavenko Y.E.,North State Medical University
Ortopedia, Travmatologia i Vosstanovitelnaa Hirurgia Detskogo Vozrasta | Year: 2017

Introduction. Pathological dislocation of The hip is one of The most severe complications of acute hematogenous osteomyelitis. The program of treatment for children withPathological hip dislocation is complex, but it has been sufficiently developed and implemented very successfully. At The same time, The available literature provides no cases of treating children withbilateral Pathological hip dislocations after hematogenous osteomyelitis. There is no information on The incidence of suchcases or in regards to remote functional results. Materials and methods. The results of The treatment of 18 children withbilateral Pathological dislocation of The hip after hematogenous osteomyelitis are presented, whichconstituted 23.1% of The total number of patients (78) who underwent surgery in 2000–2016 for The diagnosis of Pathological hip dislocation. BoThhip joints were surgically operated on in 12 patients, while one hip joint was operated on in 6 patients. To assess The anatomical and functional state of hip joints, The clinical and roentgenological diagnostic techniques were used. Results and discussion. To stabilize and restore The function of The hip joints, 18 children underwent 30 surgical interventions: simple open hip reduction (19) and open hip reduction withhip arThroplasty withone (6) or two (5) demineralized osteochondral allogeneic grafts. The decision regarding The possibility of performing surgical intervention on The second hip joint was made only after a child's check-up examination was complete and after positive information about The anatomical and functional state of The operated hip joint was obtained. According to These criteria, 14 (77.8%) children underwent surgical treatment of The second hip joint 1–1.5 years after The course of conservative measures to restore The range of motion in The previously operated hip joint. Over a period of 1–12 years, 17 patients were examined, 10 of whichunderwent an operation on boThsides (27 joints). The preservation of up to 80º or more of motion amplitude was noted in 17 (62.9%) of 27 operated hip joints. When assisting patients withPathological hip dislocation, it is necessary to understand That it is practically impossible to restore The affected joint to The anatomical state of The opposite unaffected joint. As for The bilateral lesion, This is most certainly impossible, and The development of arThrosis is inevitable. Therefore, The most important factor reflecting The degree of well-being and stability of The affected joint is The amplitude of active movements. Preserving This amplitude in The affected joints witha careful and attentive attitude is a fundamental and feasible task. © 2017, LLC Eco-Vector. All rights reserved.

Lilenko S.V.,North State Medical University
Pediatriya - Zhurnal im G.N. Speranskogo | Year: 2017

The proposed examination methods of children and adolescents complaining on poor tolerability of swing/rides and transport trips are applicable in outpatient practice of otolaryngologist and neurologist. The article describes methods of traditional otoneurological examination with a special emphasis on oculomotor reactions evaluation, including spontaneous nystagmus, with the registration of this process in terms of eye fixatione limination using Frenzel glasses. For detailed assessment of balance function in school children with motion sickness computer electrooculography was used. Author propose non-invasive, non-tiring for children and adolescents methods of saccadic gaze initialization, tracking eye movement and optokinetic nystagmus. Presented gaze tests sequence algorithms allow to make an objective assessment of vestibular. system functioning in children with motion sickness. The article formulates basics of prophylactic use of Dimenhydrinatum in school-age children with motion sickness. © 2016, Pediatria Ltd. All rights reserved.

Callaghan R.C.,University of Northern British Columbia | Callaghan R.C.,University of Toronto | Callaghan R.C.,Center for Addiction and Mental Health | Allebeck P.,Karolinska Institutet | And 2 more authors.
Cancer Causes and Control | Year: 2013

Purpose: Cannabis (marijuana) smoke and tobacco smoke contain many of the same potent carcinogens, but a critical - yet unresolved - medical and public-health issue is whether cannabis smoking might facilitate the development of lung cancer. The current study aimed to assess the risk of lung cancer among young marijuana users. Methods: A population-based cohort study examined men (n = 49,321) aged 18-20 years old assessed for cannabis use and other relevant variables during military conscription in Sweden in 1969-1970. Participants were tracked until 2009 for incident lung cancer outcomes in nationwide linked medical registries. Cox regression modeling assessed relationships between cannabis smoking, measured at conscription, and the hazard of subsequently receiving a lung cancer diagnosis. Results: At the baseline conscription assessment, 10.5 % (n = 5,156) reported lifetime use of marijuana and 1.7 % (n = 831) indicated lifetime use of more than 50 times, designated as "heavy" use. Cox regression analyses (n = 44,284) found that such "heavy" cannabis smoking was significantly associated with more than a twofold risk (hazard ratio 2.12, 95 % CI 1.08-4.14) of developing lung cancer over the 40-year follow-up period, even after statistical adjustment for baseline tobacco use, alcohol use, respiratory conditions, and socioeconomic status. Conclusion: Our primary finding provides initial longitudinal evidence that cannabis use might elevate the risk of lung cancer. In light of the widespread use of marijuana, especially among adolescents and young adults, our study provides important data for informing the risk-benefit calculus of marijuana smoking in medical, public-health, and drug-policy settings. © 2013 Springer Science+Business Media Dordrecht.

Solomennyi A.,Russian Academy of Sciences | Goncharov A.,North State Medical University | Zueva L.,North State Medical University
International Journal of Antimicrobial Agents | Year: 2015

The high incidence of mortality in patients with severe burns can be attributed to bloodstream infections caused by drug-resistant microorganisms. Multilocus variable-number tandem repeat analysis (MLVA), multilocus sequence typing (MLST) and class 1 integron PCR amplification were performed to investigate an extensively drug-resistant Acinetobacter baumannii (XDR-AB) strain recovered from a blood culture of a patient admitted to a burn intensive care unit in St Petersburg (Russian Federation). This case study describes an XDR-AB strain of multilocus sequence type ST231 with a blaGES-12 gene cassette encoding a very potent ceftazidimase located inside of a composite class 1 integron. This is the first documented case of XDR-AB belonging to the international clonal lineage I in Russia. © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Sidorov P.I.,North State Medical University
Human Ecology | Year: 2014

In the article, there have been separated factors and tendencies of changes of mental ecology in the modern world, augmentation of anomia and permissiveness, deformation of personality and social identity leading to wider and uncontrolled reproduction of social troubles and dependent disorders creating a threat to national security in the form of social epidemies. There have been described the structure and fractal ontogenetic dynamics of the demoralization syndrome. There has been grounded the synergetic approach to organization of an effective response in the form of development of a pilot model of systemic monitoring and a mental health service allowing to provide new quality of medico-psycho-socio-spiritual defense of the nation's mental health and treatment of mental illnesses.

Baryshnikova N.V.,North State Medical University
Beneficial Microbes | Year: 2012

This article presents the results of original research conducted in St. Petersburg, Russia, which showed that the Helicobacter pylori strains isolated from patients with duodenal ulcer and chronic gastroduodenitis possess significantly higher levels of the pathogenicity islands (cag-PAI) genes than the strains isolated from healthy volunteers. The most frequently detected cag-PAI genes were cagA and cagH in the strains isolated from patients with chronic gastroduodenitis, and cagA and cagE in the strains isolated from patients with duodenal ulcer. A comparison of the clinical strains isolated from patients from St. Petersburg, Russia and patients from Dushanbe, Tajikistan showed that cagA gene was more prevalent in the strains from St. Petersburg. These findings demonstrate the necessity of implementation of molecular genetic identification of H. pylori in the clinical diagnostics practice reflecting the virulent genes profile of the strain. Addition of probiotics to the standard eradication therapy of H. pylori significantly improves the results of this therapy. © 2012 Wageningen Academic Publishers.

Zheglova M.,North State Medical University
Genes and Cells | Year: 2014

The aim of the research was to give the morphofunctional characteristics of embryonic histogenesis of the female genital tract abortuses. We have studied 50 abortuses at the age of 4-12 weeks of gestation. The fixation of material and of the sample preparations were carried out according to the principles of quantitative histochemistry. According to the data obtained, paramesonefric ducts are found in the composition of the urogenital blastema to which coelomic epithelium cells can migrate. Since in this time the more differentiated ducts are mesonefric and archinephron is the organ that carries out its function, it is undeniable that the development of paramesonefric ducts goes on vector of the cranio-caudal growth of mesonefric ducts. The formation of a common utero-vaginal canal occurs through the convergence of the paramesonefric duct walls. Herewith the septum between ducts is persisted. Epitheliocytes in the medial walls of the ducts are deformed, nuclei decrease in size. The shape of the nuclei changes and rectangular nuclei dominate. The cells which have a light nucleoplasm are detected, in other cells there is a piknotic nucleus in the center; there are cells with nuclei having the semilunar shape, cells with two fragments of the nucleus, one of which is dark and the other one is light; nucleus with cuspidal protrusions at one pole, cigar-shaped nucleus. The formation of the complex relationships between the paramesonefric ducts at the entrance into mesenchymal block allows to make a suggestion on the critical period of the female genital tract development.

Aim. To comparatively evaluate the hepatoprotective activity of reamberine, remaxol, and exogenous ademethionine and a risk for unfavorable/favorable outcomes of their use in patients with liver injury during antituberculosis chemotherapy. Subjects and methods. One hundred and eighty patients with new-onset respiratory tuberculosis were examined and divided into 4 groups (45 patients in each group): Study Croup 1 (SG1): patients who took reamberine; Study Group 2 (SG2): those who received remaxol; Study Group 3 (SG3): those who had ademethionine; and a Comparative Group (CG): those who received 5% glucose solution. The test drugs were intravenously administered in a dropwise manner once daily for 10 days. The laboratory hepatic injury severity index (LHISI) was estimated according to the method described by T.N. Kalachnyuk and the risk for a favorable/unfavorable outcome was assessed, by calculating the average cost of the used hepatotropic agents. Results. LHISI increased statistically significantly with the development of liver Injury induced by antituberculosis agents. There was a statistically significant reduction in LHISI during therapy with the test hepatotropic agents versus glucose solution, the most pronounced activity being shown by remaxol. Relative risk (RR) and odds ratio (OR) assessments revealed the high likelihood of a favorable outcome (a reduction in LHISI) when each of the 3 test drugs versus glucose solution was administered; the highest RR and OR were also found in the use of remaxol. Estimation of costs and the number of patients to be treated (NPBT) in order to avoid a case of none LHLIS reduction could reveal the highest efficacy of remaxol. Conclusion. The test agents (reamberine, remaxol, and ademethionine) are effective in treating tuberculosis patients with druginduced liver injury. The administration of remaxol demonstrated the highest positive effect (as estimated by LHISI) in terms of both RR and NPBT.

Pechersky A.,North State Medical University
Central European Journal of Urology | Year: 2014

Introduction Decreasing of testosterone level is an important part of a male elderly.Material and methods To describe this phenomenon a PubMed and national databases were searched for 17β-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men.Results The reduction in intensity of the processes of tissue renewal of the testicles results in a partial androgen deficiency of aging men. A decrease in the levels of total and free testosterone and an increase in the levels of 5α-dihydrotestosterone, 17β-estradiol, sex hormone binding globulin, LH and FSH, along with a decrease in the amplitude of the rhythm of incretion of LH, FSH and total testosterone will testify to a deficiency of testosterone.Conclusions It is very important to make an individualized selection of the dose of testosterone preparation which enters the blood plasma. Key Words 5α-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men © 2014 Polish Urological Association. All rights reserved.

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