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Nanchong, China

North Sichuan Medical College , is a provincial medical school located in Nanchong city, Sichuan Province, China.North Sichuan Medical College is a government-run college of medicine in Sichuan Province and is located in the second largest higher education center of Sichuan Province, — Nanchong, a famous city, the origin of the Three Kingdoms Culture. Its two campuses occupy an area of over 823,693 square meters.NSMC has its national and international enrollment; its two campuses enroll nearly 10,000 students in undergraduate and postgraduate program. With the guidance of its motto, Commitment, Fraternity, Honesty, and Creativity, it has developed into an important national and provincial center of higher medical education, disease prevention, and rheumatism treatment since its establishment in 1951. Wikipedia.


Xie J.,U.S. National Institutes of Health | Liu G.,U.S. National Institutes of Health | Liu G.,North Sichuan Medical College | Eden H.S.,U.S. National Institutes of Health | And 2 more authors.
Accounts of Chemical Research | Year: 2011

Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally the applications have fallen into two categories: diagnosis and therapy. Because the targets are often the same, the development of separate approaches can miss opportunities to improve efficiency and effectiveness.The unique physical properties of nanomaterials enable them to serve as the basis for superior imaging probes to locate and report cancerous lesions and as vehicles to deliver therapeutics preferentially to those lesions. These technologies for probes and vehicles have converged in the current efforts to develop nanotheranostics, nanoplatforms with both imaging and therapeutic functionalities. These new multimodal platforms are highly versatile and valuable components of the emerging trend toward personalized medicine, which emphasizes tailoring treatments to the biology of individual patients to optimize outcomes. The close coupling of imaging and treatment within a theranostic agent and the data about the evolving course of an illness that these agents provide can facilitate informed decisions about modifications to treatment.Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles (IONPs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well-developed surface chemistry of these materials, researchers can load a wide range of functionalities, such as targeting, imaging and therapeutic features, onto their surfaces. This versatility makes magnetic nanoparticles excellent scaffolds for the construction of theranostic agents, and many efforts have been launched toward this goal.In this Account, we introduce the surface engineering techniques that we and others have developed, with an emphasis on how these techniques affect the role of nanoparticles as imaging or therapeutic agents. We and others have developed a set of chemical methods to prepare magnetic nanoparticles that possess accurate sizes, shapes, compositions, magnetizations, relaxivities, and surface charges. These features, in turn, can be harnessed to adjust the toxicity and stability of the nanoparticles and, further, to load functionalities, via various mechanisms, onto the nanoparticle surfaces. © 2011 American Chemical Society.


Swierczewska M.,U.S. National Institutes of Health | Swierczewska M.,State University of New York at Stony Brook | Liu G.,U.S. National Institutes of Health | Liu G.,North Sichuan Medical College | And 2 more authors.
Chemical Society Reviews | Year: 2012

High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design biomarker diagnostics. High-sensitivity recognition is achieved by signal and target amplification along with thorough pre-processing of samples. In this tutorial review, we introduce the type of detection signals read by nanosensors to detect extremely small concentrations of biomarkers and provide distinctive examples of high-sensitivity sensors. The use of such high-sensitivity nanosensors can offer earlier detection of disease than currently available to patients and create significant improvements in clinical outcomes. © 2012 The Royal Society of Chemistry.


Ma X.-J.,North Sichuan Medical College
Cancer Research and Clinic | Year: 2013

Objective: To explore the factors related to the prognosis and survival duration of primary liver cancer patients after hepatectomy. Methods: The data of primary liver cancer patients who were treated hy surgical resection were analyzed retrospectively. Kaplain-Meier method was used to evaluate survival rates. Log-rank test and Cox regression analysis were used to screen out related clinical phathology factors. Results: The median survival time was eighteen months. Univarivate analysis showed that liver function Child-Pugh classification, cirrhosis, tumor size, HBV infection, AFP, portal vein tumor thrombus significantly correlated with survival rates (P < 0.05). Multivariate analysis showed that liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus were the independent prognostic factors of primary liver cancer (P < 0.05). Conclusion: Many factors are related to the prognosis of primary liver cancer after operation. Liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus affect prognostic independently.


Liu G.,Xiamen University | Liu G.,North Sichuan Medical College | Gao J.,Xiamen University | Ai H.,University of Sichuan | Chen X.,U.S. National Institutes of Health
Small | Year: 2013

Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine. Magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism and toxicity. This review presents a broad overview of the biomedical applications and available toxicity assessments of magnetic iron oxide nanoparticles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ma X.,North Sichuan Medical College
Cancer Research and Clinic | Year: 2014

Cervical cancer is one of the most common gynecological malignancies and is the only one which has certain pathogenesis in all malignancies currently. p14ARF is one of the tumor suppressor gene discovered recently and highly expressed in almost all cervical cancer. p14ARF has high specificity and sensitivity and it is related to invasion and prognosis of cervical cancer. Therefore, p14ARF is an ideal maker that can be used to early diagnose, screening precancerous lesions and predict prognosis in cervical cancer.

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