North Sichuan Medical College

www.nsmc.edu.cn
Nanchong, China

North Sichuan Medical College , is a provincial medical school located in Nanchong city, Sichuan Province, China.North Sichuan Medical College is a government-run college of medicine in Sichuan Province and is located in the second largest higher education center of Sichuan Province, — Nanchong, a famous city, the origin of the Three Kingdoms Culture. Its two campuses occupy an area of over 823,693 square meters.NSMC has its national and international enrollment; its two campuses enroll nearly 10,000 students in undergraduate and postgraduate program. With the guidance of its motto, Commitment, Fraternity, Honesty, and Creativity, it has developed into an important national and provincial center of higher medical education, disease prevention, and rheumatism treatment since its establishment in 1951. Wikipedia.

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Liu G.,Xiamen University | Liu G.,North Sichuan Medical College | Gao J.,Xiamen University | Ai H.,University of Sichuan | Chen X.,U.S. National Institutes of Health
Small | Year: 2013

Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine. Magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism and toxicity. This review presents a broad overview of the biomedical applications and available toxicity assessments of magnetic iron oxide nanoparticles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Swierczewska M.,U.S. National Institutes of Health | Swierczewska M.,State University of New York at Stony Brook | Liu G.,U.S. National Institutes of Health | Liu G.,North Sichuan Medical College | And 2 more authors.
Chemical Society Reviews | Year: 2012

High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design biomarker diagnostics. High-sensitivity recognition is achieved by signal and target amplification along with thorough pre-processing of samples. In this tutorial review, we introduce the type of detection signals read by nanosensors to detect extremely small concentrations of biomarkers and provide distinctive examples of high-sensitivity sensors. The use of such high-sensitivity nanosensors can offer earlier detection of disease than currently available to patients and create significant improvements in clinical outcomes. © 2012 The Royal Society of Chemistry.


Ma X.-J.,North Sichuan Medical College
Cancer Research and Clinic | Year: 2013

Objective: To explore the factors related to the prognosis and survival duration of primary liver cancer patients after hepatectomy. Methods: The data of primary liver cancer patients who were treated hy surgical resection were analyzed retrospectively. Kaplain-Meier method was used to evaluate survival rates. Log-rank test and Cox regression analysis were used to screen out related clinical phathology factors. Results: The median survival time was eighteen months. Univarivate analysis showed that liver function Child-Pugh classification, cirrhosis, tumor size, HBV infection, AFP, portal vein tumor thrombus significantly correlated with survival rates (P < 0.05). Multivariate analysis showed that liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus were the independent prognostic factors of primary liver cancer (P < 0.05). Conclusion: Many factors are related to the prognosis of primary liver cancer after operation. Liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus affect prognostic independently.


OBJECTIVE:: To assess the differential features of marrow adiposity between osteoarthritis (OA) and osteoporosis (OP) in postmenopausal women using water/fat MRI. METHODS:: This cross-sectional study included 97 postmenopausal women (OA [n?=?25], OA?+?osteopenia [n?=?27], OA?+?OP [n?=?23], and OP groups [n?=?22]). Water/fat MRI, dual-energy x-ray absorptiometry and biochemical analysis were performed to assess vertebral marrow fat fraction, bone mineral density, and bone biomarkers, respectively. Harris Hip Score was recorded to evaluate hip function. RESULTS:: There were significant differences in marrow fat content among the OA, OA?+?osteopenia, and OA?+?OP groups, between OP and OA participants with normal bone mass or osteopenia (all P?


Liu Z.,North Sichuan Medical College
Cancer Research and Clinic | Year: 2014

Objective: To evaluate the diagnostic accuracy of the combination of endorectal ultrasonography and serum CEA in preoperative diagnosis of rectal wall invasion (T staging) and nodal involvement (N staging) of rectal carcinoma. Methods: We retrospectively analyzed clinical records of 310 patients with rectal carcinoma who underwent endorectal ultrasonography and serum CEA evaluation in Shanxi Province Tumor hospital from January 2007 to January 2010. The positive standard of CEA is more than 5 μg/L. The endorectal ultrasonography staging with postoperative pathological staging, and calculated the overall accuracy of T staging and N staging based on TRUS alone or on TRUS combined with serum CEA level were compared. Results: The difference in serum CEA level was statistically significant from T1 to T4 (P < 0.05). The accuracy rate of preoperative T staging of rectal carcinoma by TRUS alone was 71% (219/310) and was 82% (254/310) with TRUS combined with serum CEA level, showing significant statistical difference (χ2 = 10.92, P < 0.01). The accuracy rate of preoperative N staging of rectal carcinoma was 69% (211/308) with TRUS alone and was 77% (238/308) with TRUS combined with serum CEA level, the difference of which was statistically significant (χ2 = 5.00, P < 0.05). Conclusion: Serum CEA level increases with an increasing pathological stage of rectal cancer. The combination of TRUS and serum CEA improves the accuracy of preoperative staging of rectal cancer.


Luo X.Y.,North Sichuan Medical College
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2012

To determine the distribution of vitamin D receptor (VDR) gene ApaI and BsmI polymorphism in systemic lupus erythematosus (SLE) and the association with SLE in Chinese Han patients. Genomic DNA from 244 Chinese SLE patients and 162 sex and ethnically matched controls were typed for VDR ApaI and BsmI polymorphism combination by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Clinical characteristics were analyzed between different ApaI and BsmI genotypes. There was no significant difference between the distribution frequencies of allelic gene A and a in SLE patients and the controls, but the distribution frequency of genotypes heterozygote Aa in SLE patients was higher than that in the controls (38.9% vs 22.2%, χ(2) = 12.442, P = 0.000). There was no significant difference between the distribution frequency of allelic gene and genotypes of BsmI in SLE patients and the controls (P > 0.05). However, there was significant difference between the distribution frequencies of ApaI and BsmI genotypes combination in SLE patients and the controls (χ(2) = 18.226, P = 0.006). The distribution frequency of genotypes Aa-bb in SLE patients was higher than that in the controls (32.4% vs 17.9%, χ(2) = 10.449 P = 0.001), while the distribution frequency of genotypes Aa-bb in SLE patients was lower than that in the controls (30.3% vs 42.0%, χ(2) = 5.808, P = 0.016). Furthermore, analyzing the effect of VDR ApaI and BsmI polymorphism combination to the symptoms of SLE, significant difference was observed in SLE patients carrying Aa-bb genotypes involved in serositis (P = 0.003), hematological system disorder (P = 0.021), and anti-Sm antibodies (P = 0.01) compared with other genotypes. There is significant association between ApaI and BsmI gene polymorphism Aa-bb genotypes and the incidence of SLE in the Han population of China, and genotype Aa-bb is more involved in serositis, hematological system disorder and has a positive effect on production of antibodies.


Ma X.,North Sichuan Medical College
Cancer Research and Clinic | Year: 2014

Cervical cancer is one of the most common gynecological malignancies and is the only one which has certain pathogenesis in all malignancies currently. p14ARF is one of the tumor suppressor gene discovered recently and highly expressed in almost all cervical cancer. p14ARF has high specificity and sensitivity and it is related to invasion and prognosis of cervical cancer. Therefore, p14ARF is an ideal maker that can be used to early diagnose, screening precancerous lesions and predict prognosis in cervical cancer.


Xie J.,U.S. National Institutes of Health | Liu G.,U.S. National Institutes of Health | Liu G.,North Sichuan Medical College | Eden H.S.,U.S. National Institutes of Health | And 2 more authors.
Accounts of Chemical Research | Year: 2011

Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally the applications have fallen into two categories: diagnosis and therapy. Because the targets are often the same, the development of separate approaches can miss opportunities to improve efficiency and effectiveness.The unique physical properties of nanomaterials enable them to serve as the basis for superior imaging probes to locate and report cancerous lesions and as vehicles to deliver therapeutics preferentially to those lesions. These technologies for probes and vehicles have converged in the current efforts to develop nanotheranostics, nanoplatforms with both imaging and therapeutic functionalities. These new multimodal platforms are highly versatile and valuable components of the emerging trend toward personalized medicine, which emphasizes tailoring treatments to the biology of individual patients to optimize outcomes. The close coupling of imaging and treatment within a theranostic agent and the data about the evolving course of an illness that these agents provide can facilitate informed decisions about modifications to treatment.Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles (IONPs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well-developed surface chemistry of these materials, researchers can load a wide range of functionalities, such as targeting, imaging and therapeutic features, onto their surfaces. This versatility makes magnetic nanoparticles excellent scaffolds for the construction of theranostic agents, and many efforts have been launched toward this goal.In this Account, we introduce the surface engineering techniques that we and others have developed, with an emphasis on how these techniques affect the role of nanoparticles as imaging or therapeutic agents. We and others have developed a set of chemical methods to prepare magnetic nanoparticles that possess accurate sizes, shapes, compositions, magnetizations, relaxivities, and surface charges. These features, in turn, can be harnessed to adjust the toxicity and stability of the nanoparticles and, further, to load functionalities, via various mechanisms, onto the nanoparticle surfaces. © 2011 American Chemical Society.


Luo X.Y.,North Sichuan Medical College
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2011

To investigate the relationship of vitamin D receptor (VDR) gene Fok I polymorphism with systemic lupus erythematosus (SLE) and to observe VDR mRNA levels in Chinese Han SLE patients. Genomic DNAs from 271 Chinese SLE patients and 130 healthy controls were determined for Fok I polymorphism by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and VDR mRNA levels from 48 Chinese SLE patients and 38 healthy controls were detected by real-time polymerase chain reaction (RT-PCR). Gene frequencies of allelic F and f were significantly different between the SLE patients and the controls (P=0.001).The relative risk of SLE in the presence of allelic gene F was 1.630 (95%CI=1.210-2.196, P=0.001). The frequency of homozygote FF in the SLE patients was higher than that in the controls (42.8% vs 25.4%, x(2);=11.417, P=0.001). Serositis, anti-dsDNA antibody, anti-Sm antibody and anti-histone antibody in the SLE patients carrying homozygote FF and heterozygote Ff were higher than those in the SLE patients carrying homozygote ff (P=0.001, P=0.001, P=0.047, P=0.001, respectively). The VDR mRNA was decreased in the SLE patients, with a delta;Ct value of 9.26 ± 2.37 (P=0.026), as compared with a delta;Ct value of 7.82 ± 3.05 in the controls (the bigger of the delta;Ct value, the lower of VDR mRNA expression). The delta;Ct value of VDR mRNA in the SLE patients carrying FF and Ff was bigger than that in the SLE patients carrying ff (10.54 ± 1.88 vs 7.15 ± 3.78, P=0.019). VDR gene Fok I polymorphism is associated with SLE in the Han population of southern China. The SLE patients carrying F allel ± are more likely to have serositis and produce anti-dsDNA antibody, anti-Sm antibody and anti-Histone antibody, presumably as a result of down-regulation of VDR mRNA.


Zhou T.,North Sichuan Medical College
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2013

To compare the clinical and oncological outcomes between laparoscopic and open intersphincteric resection in patients with low rectal cancer. From January 2007 to January 2010, patients with low rectal cancer treated by laparoscopic or open intersphincteric resection were included in a retrospective comparative study. Patients were classified into laparoscopy group (n=27) and open group (n=41). The operative procedures, postoperative complications, anal function and clinicopathological data were compared. Compared to the open group, the laparoscopic group had longer operative time [(242.2±42.5) min vs. (199.1±44.3) min, P=0.000], less blood loss [(150.5±102.2) ml vs. (258.4±149.2) ml, P=0.002], faster recovery of bowel function [(2.9±1.1) d vs. (3.6±1.5) d, P=0.032] and resumption of regular diet [(6.6±1.2) d vs. [(7.5±1.7) d, P=0.012], and shorter postoperative hospital stay [(7.7±1.4) d vs. (9.1±2.4) d, P=0.006]. The postoperative complication rate between the laparoscopic and open groups was not significantly different [18.5% (5/27) vs. 19.5% (8/41), P=0.464]. Oncological parameters were comparable between the two groups including lymph node harvested [(14.1±4.1) vs. (16.4±6.8), P=0.113], distal resection margin [(1.4±0.7) cm vs. (1.6±0.8) cm, P=0.311], and circumferential margin [7.4% (2/27) vs. 2.4% (1/41), P=0.709]. Local recurrence rates in laparoscopic and open groups were 7.4% (2/27) and 2.4% (1/41), and distant metastasis rates were 0 and 4.9% (2/41) respectively, and the differences were not significant (both P>0.05). Laparoscopic intersphincteric resection possesses same efficacy of open intersphincteric resection with less blood loss, shorter recovery time and hospital stay, and similar oncological outcomes, and no increased postoperative morbidity and mortality.

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