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Kisieva Z.A.,North Ossetian State Medical Academy | Brin V.B.,North Ossetian State Medical Academy
Medical News of North Caucasus | Year: 2016

The aim of the study was to investigate the prophylactic effect of Mildronat and Atsizol on morphological and functional renal parameters in animals undergone the native sheep plasma injection. In the experiment, the simultaneous injection of Acyzol and Mildronat since the early period of the native sheep plasma injection contributes to the reduction of the amyloid nephropathy manifestations. We detected less severely impaired renal filtration capacity, tubular water reabsorption, sodium and potassium and calcium excretion, reduction of proteinuria. Histological study of the kidneys, heart, liver and spleen tissue revealed a decreased amyloid accumulation in the stromal-vascular structures.

Ahpolova V.O.,North Ossetian State Medical Academy | Brin V.B.,North Ossetian State Medical Academy | Tsallaeva R.T.,North Ossetian State Medical Academy
Medical News of North Caucasus | Year: 2016

The concentrations of calcium, lead and zinc in bone tissue of rats with short-term lead and zinc intoxication, both isolated and in conditions of hypo-and hypercalcaemia were studied. It is shown that experimental hypoparathyroidism slightly mitigates the effect of lead acetate intragastric administration on the bone tissue, but doesn't change significantly the manifestations of short-term zinc intoxication. Calcitonin hypocalcaemia, experimental hypervitaminosis D increase the accumulation of lead and zinc in the bone matrix in their intragastral admission. In parathyroidectomized rats with subcutaneous injections of metals the largest shifts in the mineral composition of the bone tissue are observed - marked calcification of the bones with parallel accumulation of lead and zinc takes place. Experimental hypercalcaemia, created by both ways, on the contrary, is characterized by the higher concentrations of calcium and low rates of lead and zinc accumulation in femur in their parenteral intake.

PubMed | Republican Clinical Hospital, North Ossetian State Medical Academy and North Caucasian Multidisciplinary Medical Center
Type: Journal Article | Journal: Terapevticheskii arkhiv | Year: 2017

To determine the nature of changes in fibroblast growth factor 23 (FGF-23) and other bone mineral metabolism parameters detectable in the blood of patients with end-stage chronic renal failure (CRF) and to analyze their links to the development of cardiovascular events in uremic intoxication.A total of 75 patients (45 men and 30 women) aged 23 to 66 years (mean age, 532.1 years) with Stage VD CKF were examined. The levels of parathyroid hormone (PTH), calcium, phosphorus, the morphogenetic protein FGF-23, and the cardiospecific protein troponin I were investigated. Doppler echocardiography was performed on an Aloka 4000 machine. Left ventricular (LV) mass index (LVMI), LV systolic and diastolic function, and peak systolic blood flow velocity in the aortic arch (Vps) were estimated.As LVMI became higher, there were increases in the level of PTH and that of FGF-23 that plays a significant role in the processes of bone remodeling and vascular calcification. Analysis of correlations between a change in FGF-23 concentrations depending on the morphological and functional parameters of the cardiovascular system (CVS) revealed a strong direct correlation between FGF-23 levels and LVMI (r=0.746; p<0.01), a significant inverse correlation between FGF-23 and ejection fraction (r=-0.901; p<0.05), and a direct correlation of FGF-23 and troponin I (r=0.544; p<0.05).FGF-2 increasing from moderate to very high levels indicates that there is a high risk for remodeling processes in the CVS even in the absence of baseline echocardiographic signs of myocardial hypertrophy, normal aortic pulse wave velocity, and compensation of other risk factors, such as hypertension, uremia, hyperparathyroidism, even without increasing the markers of cardiovascular events, such as hyperphosphatemia. The elevated level of FGF-23 suggests that there is a need for cardioprotective therapy, the goal of which is to correct of the level of this factor.

PubMed | Russian National Research Medical University, Chuvash State University and North Ossetian State Medical Academy
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN- and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4(+) T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN- content. The content of IL-17 was shown to decrease above the detection limit.

Zhenilo V.M.,Rostov State Medical University | Avsaragova A.Z.,North Ossetian State Medical Academy | Astakhova Z.T.,North Ossetian State Medical Academy
Eksperimental'naya i Klinicheskaya Farmakologiya | Year: 2016

The effectiveness of drug remaxol inclusion in the pcheme of treatment of patients with myocardial infarction on the background of degree II-III acute cardiac insufficiency was evaluated by the analysis of clinical and laboratory data of 126 patients with newly diagnosed acute myocardial infarction including ST-segment elevation on the background of acute cardiac insufficiency. Depending on the regimen, patients were divided into two groups. The first (control) group included 60 patients who received conventional thrombolytic therapy; the second (main) group included 66 patients which, after thrombolytic therapy, received remaxol (single daily intravenous administration, 400 mL at 3-4 mL/min rate) with controlled central venous pressure, arterial pressure, and diuresis. The course lasted for 3-5 days, depending on the severity of condition. A high efficiency of the treatment regimen including remaxol was established as characterized by more rapid (in comparison to conventional therapy) stabilization of disturbed systemic hemodynamics and recovery of weakened myocardial contractility, decreased risk of cardiac arrhythmias, and relieved hyperhomocysteinemia that, in turn, reduced the risk of complications such as thrombosis and thromboembolism.

Khubaeva T.O.,North Ossetian State Medical Academy | Khubaeva I.V.,North Ossetian State Medical Academy
Russian Journal of General Chemistry | Year: 2013

Antioxidant activity of benzimidazole derivatives with sterically hindered phenol substituent has been estimated using the modified procedure. The compounds antioxidant activity is strongly correlated with the potential of peroxide oxidation of the corn oil lipids of polyunsaturated aliphatic acids. © 2013 Pleiades Publishing, Ltd.

Aksenova I.Z.,North Ossetian State Medical Academy | Burduli N.M.,North Ossetian State Medical Academy
Terapevticheskiĭ arkhiv | Year: 2016

AIM: To study the impact of low-intensity laser therapy (LILT) on typical pathological processes of impairments in platelet aggregation and microcirculation (MC) in patients with chronic obstructive pulmonary disease (COPD).MATERIALS AND METHODS: A photo optical aggregatometric method was used to investigate platelet aggregation function in patients with COPD and MC was estimated by laser Doppler flowmetry over time.RESULTS: There were muitidirectional changes in platelet aggregation function with a predominance of hyperaggregation, as well as a significant improvement in aggregation indicators during LILT; the latter was shown to have a correcting impact on MC disorders in patients with COPD in the presence of the spastic and stagnant-stasic types of MC, which were prevalent in the majority of patients.CONCLUSION: Laser therapy used in the combination treatment of patients with COPD promotes correction of the typical pathological processes.Abstract available from the publisher.

Burduli N.M.,North Ossetian State Medical Academy | Piliyeva N.G.,North Ossetian State Medical Academy
Terapevticheskii Arkhiv | Year: 2010

Aim. To study the time course of changes in the activity of the protein C system and other hemostatic parameters under intravascular laser irradiation of blood (ILIB) in patients with community-acquired pneumonia (CAP). Subjects and methods. One hundred and forty patients aged 17 to 62 years (mean 39.5 ± 8.4 years) with CAP were examined. A control group (n = 40) received conventional drug therapy; the study group (n = 100) had a course of ILIB in addition to conventional therapy. Results. Before treatment, the patients with CAP were observed to have a lower protein C system activity and the signs of hypercoagulation that were eliminated by ILIB. Conclusion. ILIB is an effective method in correcting hemocoagulative disorders in patients with CAP.

PubMed | Russian National Research Medical University, Chuvash State University and North Ossetian State Medical Academy
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.

PubMed | Volgograd State University, Ryazan State Medical University and North Ossetian State Medical Academy
Type: | Journal: Khirurgiia | Year: 2016

To study surgeons awareness about safety of patients in surgery and to determine necessary educational measures in this area.110 surgeons were interviewed. Mean length of work was 16.10.97 years. 88.2% of surgeons worked at hospitals. 47.3% of surgeons were engaged elective surgery.Previously 55.5% of respondents were involved into conflict with patients. A half of respondents are familiar with WHO program About patient safety and key issues of patient safety during prevention of postoperative thromboembolic and infectious complications. 76% of respondents have the possibility to use videoendoscopic technologies, but only 36% of them realize these techniques. Up to 33% of respondents consider to be studied at certification cycles only. Many surgeons use the Internet as the main source of information.Current tendencies of surgical development require to focus on perioperative safety and the need for intensive research of the technologies of surgical patients safety.

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