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Albegova D.Z.,Russian National Research Medical University | Kamkina O.V.,Russian National Research Medical University | Pavlova S.I.,Chuvash State University | Albegova Z.K.,North Ossetian State Medical Academy | Kozlov I.G.,Russian National Research Medical University
Bulletin of Experimental Biology and Medicine | Year: 2015

An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4+ T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit. © 2015, Springer Science+Business Media New York. Source

Temiraev V.K.,Gorsky State Agrarian University | Kairov V.R.,Gorsky State Agrarian University | Kalagova R.V.,North Ossetian State Medical Academy
Biology and Medicine | Year: 2014

In recent years, use of mycotoxins and antioxidants sorbents in cattle breeding is of considerable interest. Feeding these sorbents makes it possible to improve digestion process, metabolism, and productivity of animals, and improve product quality and economic performance. To this end, the aim of the research was to determine feasibility and advisability of treating fattening young cattle with a combination of biologically active preparations as a biological stimulant in order to improve their physiological and biochemical status and, consequently, to increase indicators of nutrients conversion into food products, fattening and meatiness, and profitability. Studies have shown that simultaneous presence of the ehpophen antioxidant and the toxisorb sorbent in rations of fattening young cattle stimulates physiological and biochemical processes in the organism, contributes to growth intensity, and reduces forage consumption per unit of output. Source

Brin V.B.,Russian Academy of Sciences | Mittsiev K.G.,Russian Academy of Sciences | Mittsiev A.K.,North Ossetian State Medical Academy | Kabisov O.T.,Russian Academy of Sciences
Medical News of North Caucasus | Year: 2015

Copper belongs to the essential trace elements, but an excess of it leads to the development of morphological and functional changes of the internal organs. Most sensitive to the toxic effects of copper is the cardiovascular system. It is known that calcium is a competitive biometals for xenobiotics and artificial condition of hypercalcemia, is used to prevent the toxic effects of heavy metals. However, work on the study of the cardiovascular effects of copper toxicity in terms of hypocalcemia not. Because of this, the aim was to study the effect of copper toxicity on the functional state of the cardiovascular system. A study of the functional state of the cardiovascular system is to identify the main hemodynamic and reactivity of the renin-angiotensin system and adrenoreactivity cardiovascular system. As a result of experimental studies have shown that prolonged delivery copper in the body leads to the development of hypertension and reduce the performance of the pumping functions of the heart. Experimental condition hypocalcemia, promotes a more pronounced toxic effects of copper sulfate on the cardiovascular system. Source

Burduli N.M.,North Ossetian State Medical Academy | K.gutnova S.,North Ossetian State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2010

Ceruloplasmin content in the blood plasma significantly increased in patients with chronic pancreatitis during exacerbation of the disease. Addition of intravenous laser irradiation of the blood to complex therapy of patients with chronic pancreatitis normalized ceruloplasmin content in the plasma. © 2010 Springer Science+Business Media, Inc. Source

Khubaeva T.O.,North Ossetian State Medical Academy | Khubaeva I.V.,North Ossetian State Medical Academy
Russian Journal of General Chemistry | Year: 2013

Antioxidant activity of benzimidazole derivatives with sterically hindered phenol substituent has been estimated using the modified procedure. The compounds antioxidant activity is strongly correlated with the potential of peroxide oxidation of the corn oil lipids of polyunsaturated aliphatic acids. © 2013 Pleiades Publishing, Ltd. Source

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