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Patil R.H.,Commerce and Science College | Prakash K.,North Maharashatra University | Maheshwari V.L.,North Maharashatra University
Indian Journal of Clinical Biochemistry | Year: 2010

The objective of the present study was to evaluate hypolipidemic effect of methanolic extract of Celastrus paniculatus in experimentally induced hypercholesterolemic rats. Hypercholesterolemia was induced by feeding the animals with high fat diet. Oral administration of methanolic seed extract (50%) of Celastrus paniculatus at the optimized dose of 65 mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL cholesterol in comparison with induced hypercholesterolemic animal group and the results were comparable with the standard hypocholesterolemic drug and almost similar to the control group. Atherogenic index and liver weight of treated animals also showed significant decrease compared to the hypercholesterolemic animals. It substantially increased the HDL cholesterol level as compared to control group. A significant increase in the activities of lipoprotein lipase and plasma LCAT enhanced hepatic bile acid synthesis and thereby, increased degradation of cholesterol to neutral sterols. Furthermore, the activities of HMG-CoA reductase, glucose 6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Histological studies showed less cholesterol deposits in the aorta of animals fed with seed extract of C. paniculatus compared to the induced hypercholesterolemic animals not given C. paniculatus supplement. © Association of Clinical Biochemists of India 2010. Source


Patil R.H.,Commerce and Science College | Prakash K.,North Maharashatra University | Maheshwari V.L.,North Maharashatra University
Acta Biologica Szegediensis | Year: 2011

The hypolipidemic activity of the 50% ethanol extract of bark of T. arjuna were evaluated in rats. The 50% v/v ethanol bark extract at the dose of 40mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL cholesterol while HDL cholesterol increased in experimental group in comparison with hypercholesterolemic animal group. Atherogenic index and liver weight of treated animals also showed significant decrease. A significant increase in the activities of lipoprotein lipase and plasma LCAT enhanced hepatic bile acid synthesis and thereby increased degradation of cholesterol to neutral sterols. Furthermore, the activities of lipogenic enzymes like HMG-CoA reductase, glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. The bark extract of Terminalia arjuna has excellent hypolipidemic activity. The effect of the extract seems to be mediated through increased hepatic clearance of cholesterol, down regulation of lipogenic enzymes and inhibition of HMG- CoA reductase. Source


Patil R.H.,Commerce and Science College | Krishnan P.,North Maharashatra University | Maheshwari V.L.,North Maharashatra University
Natural Product Communications | Year: 2011

A wild fungal strain of Aspergillus terreus, labeled as PM3, was isolated by using the Candida albicans bioassay and confirmed by 18S r DNA analyses. Lovastatin was produced by submerged and solid state fermentations. Of the 30 isolated fungal strains, 11 showed lovastatin production with Aspergillus terreus PM3 being the best with a yield of 240 mg/L at the 10 th day of submerged fermentation. Carboxymethylcellulose had a stimulatory effect on lovastatin production. It restricted uncontrolled filamentous growth, induced pellet formation and, thereby, improved lovastatin yield. In solid state fermentation (SSF), of the agro wastes from five crops (bran of wheat and rice, husks of red gram and soybean, and green gram straw), wheat bran showed maximum lovastatin production (12.5 mg/g of dry substrate) at pH 7.1 and a temperature of 30±2°C. Development of a lovastatin production process based on wheat bran as a substrate in SSF is economically attractive as it is a cheap and readily available raw material in agriculture-based countries. Source

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