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Jha D.,North DMC Medical College | Thakkar H.K.,North DMC Medical College | Kumar R.,Gold Field Institute of Medical science and Research
Journal of Communicable Diseases | Year: 2015

This study was undertaken to analyze the meningococcal carrier state in six months follow up in the Armed forces setup. The study was carried out on 360 recruits in the age group of 16-25 years at the time of joining the training center. Overall prevalence of meningococcal carrier at the time of enrolment was 11.94% (43). It increased to 12.77% (46) after three months (first follow up) and 15% (54) after six months (second follow up). A total of 22 (6.9%) recruits acquired carrier status during the course of training, which entailed close proximity and long periods of aggregation in the class room, parade ground, dining hall and even during sleep hours. All the cultures grown were serotyped and antibiotic sensitivity was studied. Only serogroup A was identified. In addition, all cultures grown were found sensitive to sulphonamide, penicillin and rifampicin. © 2015 ADR Journals. All Rights Reserved.


Pandey V.,Kasturba Medical College | Bandi A.,North DMC Medical College | Madi S.,Kasturba Medical College | Agarwal L.,Kasturba Medical College | And 4 more authors.
Journal of Shoulder and Elbow Surgery | Year: 2016

Background: Platelet-rich plasma (PRP) has the potential to improve tendon-bone healing. The evidence is still controversial as to whether PRP application after repair of medium-sized to large cuff tears leads to superior structural and clinical outcome, especially after single-row repair. Methods: In a randomized study, 102 patients (PRP group, 52 patients; control group, 50 patients) with medium-sized and large degenerative posterosuperior tears were included for arthroscopic repair with a minimum follow-up of 2 years. Patients were evaluated with clinical scores (visual analog scale score, Constant-Murley score, University of California-Los Angeles score, and American Shoulder and Elbow Surgeons score) and ultrasound to assess retear and vascularity pattern of the cuff. Results: Visual analog scale scores were significantly lower in the PRP group than in controls at 1 month, 3 months, and 6 months but not later. Constant-Murley scores were significantly better in the PRP group compared with controls at 12 and 24 months, whereas University of California-Los Angeles scores were significantly higher in the PRP group at 6 and 12 months (P < .05). The American Shoulder and Elbow Surgeons score in both groups was comparable at all the times. At 24 months, retear in the PRP group (n = 2; 3.8%) was significantly lower than in the control group (n = 10; 20%; P = .01). The retear difference was significant only for large tears (PRP:control group, 1:6; P = .03). Doppler ultrasound examination showed significant vascularity in the PRP group repair site at 3 months postoperatively (P < .05) and in peribursal tissue until 12 months. Conclusion: Application of moderately concentrated PRP improves clinical and structural outcome in large cuff tears. PRP also enhances vascularity around the repair site in the early phase. © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees.


PubMed | Kasturba Medical College, North DMC Medical College and Shoulder Unit
Type: Journal Article | Journal: Journal of shoulder and elbow surgery | Year: 2016

Platelet-rich plasma (PRP) has the potential to improve tendon-bone healing. The evidence is still controversial as to whether PRP application after repair of medium-sized to large cuff tears leads to superior structural and clinical outcome, especially after single-row repair.In a randomized study, 102 patients (PRP group, 52 patients; control group, 50 patients) with medium-sized and large degenerative posterosuperior tears were included for arthroscopic repair with a minimum follow-up of 2 years. Patients were evaluated with clinical scores (visual analog scale score, Constant-Murley score, University of California-Los Angeles score, and American Shoulder and Elbow Surgeons score) and ultrasound to assess retear and vascularity pattern of the cuff.Visual analog scale scores were significantly lower in the PRP group than in controls at 1 month, 3 months, and 6 months but not later. Constant-Murley scores were significantly better in the PRP group compared with controls at 12 and 24 months, whereas University of California-Los Angeles scores were significantly higher in the PRP group at 6 and 12 months (P<.05). The American Shoulder and Elbow Surgeons score in both groups was comparable at all the times. At 24 months, retear in the PRP group (n=2; 3.8%) was significantly lower than in the control group (n=10; 20%; P=.01). The retear difference was significant only for large tears (PRP:control group,1:6; P=.03). Doppler ultrasound examination showed significant vascularity in the PRP group repair site at 3 months postoperatively (P<.05) and in peribursal tissue until 12 months.Application of moderately concentrated PRP improves clinical and structural outcome in large cuff tears. PRP also enhances vascularity around the repair site in the early phase.


Panda A.,All India Institute of Medical Sciences | Panda A.,Hindu Rao Hospital | Pal Singh T.,All India Institute of Medical Sciences | Satpathy G.,All India Institute of Medical Sciences | And 2 more authors.
International Ophthalmology | Year: 2015

To assess utility of PCR in the diagnosis of bacterial corneal ulcer and to compare sensitivity and specificity of this technique with conventional laboratory methods. A prospective nonrandomized investigative study conducted on 122 eyes of presumed bacterial keratitis. Samples were collected for bacterial and fungal culture and Gram stain smear. A separate sample was taken for PCR with 26 gauge needle and was dipped directly into eppendorff tube with lysis buffer in it. Diagnosis of culture proven bacterial keratitis was established in 53 (43.4 %) and most common bacterial isolate was staphylococcal sp. (83 %). Direct microscopic examination of Gram stained smear revealed presence of bacteria in 24 (23.9 %) specimens and PCR positivity was evident in 56 (45.5 %). In preantibiotic treated eyes culture was positive in 15 (30 %), Gram stain in 9 (18 %), and PCR in 18 (36 %). The same for untreated (fresh) eyes, positivity of culture as well as PCR was noted in 38 (52.7 %) and that of Gram stain was noted in 20 (27.7 %). Sensitivity of Gram stain and PCR was 45.28 and 88.68 % respectively; whereas specificity was 92.75 % for Gram stain and 86.96 % for PCR. The average time taken for PCR reaction was 4–8 h while culture reporting took at least 24–48 h. Our findings suggest that PCR is a good adjunct modality to the “Gold Standard” technique in the diagnosis of bacterial corneal ulcer. © 2014, Springer Science+Business Media Dordrecht.


Kumar N.,Maulana Azad Medical College | Singh P.,North DMC Medical College | Kumar J.,Maulana Azad Medical College | Dhanwal D.K.,Maulana Azad Medical College
BMJ Case Reports | Year: 2014

Sheehan syndrome is a rare but potentially serious complication of postpartum haemorrhage. The diagnosis can often be delayed by many years as symptoms may be subtle. We report the case of a 45-year-old woman who presented to the medical emergency unit with acute onset altered sensorium. On further evaluation she was found to have severe hypoglycaemia which was corrected by giving intravenous dextrose. On detailed clinical evaluation, she had a history of agalactia and amenorrhoea following her last pregnancy which was 15 years ago. She had a history of excessive postpartum bleeding during her last delivery. MRI of the brain showed empty sella and hormonal evaluation revealed adenohypophyseal insufficiency as evident from decreased levels of cortisol, thyroid-stimulating hormone, triiodothyronine, free thyroxine, follicle-stimulating hormone, luteinising hormone and prolactin. Based on clinical, radiological and laboratory parameters her final diagnosis was Sheehan syndrome with hypoglycaemia. Copyright 2014 BMJ Publishing Group. All rights reserved.


Bej P.,North DMC Medical College
Indian Journal of Community Health | Year: 2015

Adolescence is a period in which all the habits and behaviour like high risk behaviour, substance abuse and eating habits develop that have lifelong impact. In India, programmes have been launched to address all the problems faced during adolescent period, still then adolescents are facing problems. In this review the problems faced by Indian adolescents were highlighted from the past 14 years’ studies. The studies were searched from 2001 to 2015 from Pub Med, Google scholar and other community medicine and public health related journals. The problems included were sexual health and teenage pregnancy, problems related to menstruation, illicit drugs, tobacco and alcohol use. Anaemia, eating problems, obesity, behavioural problems and oral health among adolescent were also reviewed. Nineteen abstracts and 52 full texts were available. Sexual health knowledge among adolescent varies from 41% to poor. Knowledge about sexually transmitted diseases and sexuality is less. Prevalence of dysmenorrhoea varies from 67. 2% to 56. 15% among adolescent girls. Prevalence of tobacco use varies from 25. 1 to 12%. Prevalence of obesity varies from 3. 4% to 0. 35% and overweight varies from 5. 5% to 5. 84%. Prevalence of anaemia varies from 29% to 41. 1%. Adolescents are facing depressive problems, physical fights, worry and loneliness. Prevalence of depression varies from 18. 4% to 13. 3%. Prevalence of dental problems varies from 18. 2 to 41%. The review revealed that adolescents in India are facing problems of sexually transmitted infections, dysmenorrhea, tobacco and alcohol use, depression, physical fights, worry, loneliness and oral health problems. This needs a participation of family, community and government to resolve the issue. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.

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