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Wang J.,North China Coal Medical College | Wang G.,North China Coal Medical College | Wu J.,North China Coal Medical College | Su Y.,North China Coal Medical College
Applied Mechanics and Materials | Year: 2011

Artificial neural network is based on human brain structure and operational mechanism based on knowledge and understanding of its structure and behavior of simulated an engineering system. BP artificial neural network is an important component of neural networks, as it can on the linear or nonlinear multivariable without preconditions in the case of statistical analysis, with the traditional statistical methods, analysis of the variables need to be consistent with certain conditions compared to its own advantage. The BP neural network does not need the precise mathematical model, does not have any supposition request to the material itself. Its processing non-linear problem's ability is stronger than traditional statistical methods. This article uses two groups of data to establish the BP neural network model separately, and carries on the comparison to the model fitting ability and the forecast performance, discovered BP neural network when data distribution relative centralism fits ability, forecasts the stable property. But the predictive ability is unable in the discrete data application to achieve anticipated ideally. © (2011) Trans Tech Publications.


Wu J.,North China Coal Medical College | Wang G.,North China Coal Medical College | Wang J.,North China Coal Medical College | Su Y.,North China Coal Medical College
Applied Mechanics and Materials | Year: 2011

The BP neural network is the important component of artificial neural networks, and gradually becomes a branch of the computation statistics. With its many characteristics such as large-scale parallel information processing, excellent self-adaptation and self-learning, the BP neural network has been used in solving the complex nonlinear dynamic system prediction. The BP neural network does not need the precise mathematical model, does not have any supposition request to the material itself. Its processing non-linear problem's ability is stronger than traditional statistical methods. By means of contrasting the BP neural network and the multi-dimensional linear regression ,this article discoveries that the BP neural network fitting ability is more stronger, the prediction performance is more stable, may be further applied and promoted in analysis and forecast of the continual material factor. © (2011) Trans Tech Publications.


Wang G.,North China Coal Medical College | Wu J.,North China Coal Medical College | Su Y.,North China Coal Medical College
Advanced Materials Research | Year: 2011

Ant colony algorithm is a kind of effective combinatorial optimization problem solving algorithm has been increasingly, thorough research, and gradually get used. Ant colony algorithm is a set of parameters, the algorithm, a lack of adequate experiences often. The paper has put forward a single genetic character of ant colony algorithm. Will the ant colony algorithm each search results as the initial population, single genetic improvement, for the shortest route optimization. In the traveling salesman problem of the experiments prove the effectiveness of the proposed algorithm. © (2011) Trans Tech Publications.


Wang F.,Ford Motor Company | He Q.,Ford Motor Company | Sun Y.,Ford Motor Company | Sun Y.,North China Coal Medical College | And 2 more authors.
Hypertension | Year: 2010

Premenopausal women have less cardiovascular disease and lower cardiovascular morbidity and mortality than men the same age. Our previous studies showed that female mice have lower mortality and better preserved cardiac function after myocardial infarction. However, the precise cellular and molecular mechanisms responsible for such a sex difference are not well established. Using cultured adult mouse cardiomyocytes, we tested the hypothesis that the survival advantage of females stems from activated estrogen receptors and Akt survival signaling pathways. Adult mouse cardiomyocytes were isolated from male and female C57BL/6J mice and treated with hydrogen peroxide (100 μmol/L) for 30 minutes. Cell survival was indicated by rod ratio (rod shaped cells:total cells), cell death by lactate dehydrogenase release, and positive staining of annexin-V (a marker for apoptosis) and propidium iodide (a marker for necrosis). In response to hydrogen peroxide, female adult mouse cardiomyocytes exhibited a higher rod ratio, lower lactate dehydrogenase release, and fewer Annexin-V-positive and propidium iodide-positive cells compared with males. Phospho-Akt was greater in females both at baseline and after hydrogen peroxide stimulation. The downstream molecule of Akt, phosphor-GSK-3β (inactivation), was also higher, whereas caspase 3 activity was lower in females in response to hydrogen peroxide. Bcl-2 did not differ between sexes. Estrogen receptor-α was the dominant isoform in females, whereas estrogen receptor-β was low but similar in both sexes. Our findings demonstrate that female adult mouse cardiomyocytes have a greater survival advantage when challenged with oxidative stress-induced cell death. This may be attributable to activation of Akt and inhibition of GSK-3β and caspase 3 through an estrogen receptor-α-mediated mechanism. Copyright © 2010 American Heart Association. All rights reserved.


Wang G.,North China Coal Medical College | Wu J.,North China Coal Medical College | Yin S.,North China Coal Medical College | Yu L.,North China Coal Medical College | Wang J.,North China Coal Medical College
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

BP neural network and multiple linear regression model can be used for multi-factor analysis and forecasting, but the data of the multiple linear regression required to meet independence, normality and other conditions, while the data of the BP neural network do not need to. This article uses the same set of data to established BP neural network model and multiple linear regression model, then compare the ability of fitting and forecasting of the two kinds of models finding that BP neural network has a strong fitting ability and a stable ability of prediction, which can be further used and promoted in the anglicizing and forecasting of the continuous data factors. © 2010 Springer-Verlag Berlin Heidelberg.


Yan L.,North China Coal Medical College | Zhang Y.,North China Coal Medical College | Yao L.,North China Coal Medical College | Xu H.,North China Coal Medical College
Applied Mechanics and Materials | Year: 2011

The aim of the current study is to figure out the relationship between the oxidative damage in cardiovascular system and lead exposure. Oxidative damage was investigated in the heart and aorta of rats exposed to lead acetate for 6 weeks. Male wistar rats were randomly divided into three groups: low-dose (10 mg/kg), high-dose (40 mg/kg) lead acetate and control groups. The rats in low-, or high-dose groups were received 10 mg/kg and 40 mg/kg lead acetate by garages, and the rats in control group were administrated same amount distilled water only. We compared the three groups in terms of the level of T-SOD, NOS, and MDA in serum and heart, aorta and histological examination. We found the activity of T-SOD, NOS in rats treated with low and high doses of lead acetate were significantly lower than in the control group. The content of MDA in the low and high doses of lead acetate groups was significantly higher than in the control group. In addition, the microscopic morphology of heart and aorta in the low- and high-dose groups showed differences from the control. Oxidative damage may be involved in the process of heart and aorta dysfunction induced by lead exposure. © (2011) Trans Tech Publications.


Men X.,North China Coal Medical College | Han S.,North China Coal Medical College | Gao J.,North China Coal Medical College | Cao G.,Tangshan College | And 4 more authors.
Acta Orthopaedica | Year: 2010

Background and purpose CHOP is a C/EBP family transcription factor involved in endoplasmic reticulum (ER) stress-mediated apoptosis. Several studies have demonstrated that ischemia reperfusion results in apoptosis. Oxidative stress is central to ischemia reperfusion-induced apoptosis. Taurine protects against lung injury after limb ischemia reperfusion (LIR) through antioxidation. The effects of taurine on ER stress-induced apoptosis have not been well explored, however. We studied the effects of taurine in ER stress-induced apoptosis following LIR. Methods Adult male Sprague-Dawley rats (n=40) were randomized into 4 groups: (1) a control group, (2) an LIR group, (3) an LIR group treated with taurine, and (4) an LIR group treated with saline. Bilateral hindlimb ischemia was induced by application of a rubber band proximal to the level of the greater trochanters for 4 h. The treatment groups received either taurine (200 mg/kg as a 4% solution in 0.9% saline) or saline alone prior to reperfusion. Following 4h of reperfusion, blood oxygen was analyzed. The animals were killed and plasma and lung tissue were harvested for evaluation. Results Taurine statistically significantly attenuated lung injury following LIR, as shown by reduced malondialdehyde content, reduced cell apoptosis, and expression of activating transcription factor 4 (ATF4), X-box binding protein 1 (XBP1), and transcriptional activators of the CHOP gene. Furthermore, partial pressure values of oxygen in arterial blood and the activities of superoxide dismutase and catalase were higher in the taurine pretreatment group than in the group of rats that underwent LIR alone. Interpretation Our results suggest that taurine attenuates endoplasmic reticulum stress-induced apoptosis in the lungs of rats after limb ischemia reperfusion.


Peng H.B.,North China Coal Medical College
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2010

To study the proliferation effect of the AM supernatant incubated activation of p38 mitogen activated protein kinases (p38MAPK) signal transduction pathway in human embryonic lung fibroblasts, and to participate in the development of fibrosis in silicosis. The silicotic alveolar macrophages were collected by bronchoalveolar lavage and incubated in vitro in the DMEM medium containing SiO 2 (50 μg/ml) and DMEM medium without SiO 2 for 18 h. Then the AM supernatant incubated for 18 h was collected. HELFs were isolated by organize paste block method, and incubated with AM supernatants. HELFs were divided into four groups: blank control groups, AM groups, SiO 2 + AM groups, SB203580 + SiO 2 + AM groups. The proliferation in the HELF was detected with MTT method and Flow cytometry. The proliferation in the HELF acted with the conditioned AM supernatant fluid were more than blank control groups, AM groups and SB203580 + SiO 2 + AM groups [average optical density: (0.48 ± 0.03) vs (0.29 ± 0.01), (0.38 ± 0.02), (0.33 ± 0.03)], the values with MTT method were statistically different (P < 0.05); Proliferous index with flow cytometry in SiO 2 + AM groups (18.12 ± 0.82) was bigger than blank control groups (9.24 ± 0.48), AM groups (14.76 ± 0.43) and SB203580 + SiO 2 + AM groups (11.71 ± 0.70) and the values were statistically different(P < 0.05). The AM supernatant stimulated by silicon dioxide can accelerate the proliferation in the HELF by activation of p38MAPK signal transduction pathway.


Zheng S.,North China Coal Medical College | Zheng S.,Indiana University | Chang Y.,Kailuan Hospital | Hodges K.B.,Indiana University | And 8 more authors.
Anticancer Research | Year: 2010

KISS1 and matrix metalloproteinase-9 (MMP-9) may play important roles as metastasis suppressor and metastasis promoter genes, respectively, in a variety of malignancies. However, there is little information about their possible roles in non-small cell lung cancer (NSCLC). The goals of this study were to determine the mRNA and protein expressions of KISS1 and MMP-9 in NSCLC and their relations to metastasis and prognosis. The mRNA and protein expressions of KISS1 and of MMP-9 protein were detected by in situ hybridization and immunohistochemistry respectively in 85 cases of NSCLC, and their matched lymph node metastases. Expressions of KISS1 mRNA and protein were significantly higher in low TNM stages of NSCLC (I-II) compared to more advanced stages (HI-IV) (p<0.05). Moreover, in advanced TNM stages, cases without metastasis had higher KISS1 gene expression compared to those with lymph node metastasis (p<0.05). In contrast, MMP-9 expression was higher in stage IH-IV NSCLC cases compared to stage I-II tumors (p<0.05) and higher in NSCLC cases with metastasis than those without metastasis (p<0.05). There was negative correction between KISS1 and MMP-9 protein expression (p<0.01). The 5-year survival rate in cases with higher KISS1 protein expression was significantly higher than in those with low expression (20.9 vs. 2.4%, p<0.01). However, the 5-year survival rate of patients with high MMP-9 protein expression were lower than those with low expression (19 vs. 4.7%, p<0.05). Our data suggest that KISS1 and MMP-9 may serve as potential prognostic and therapeutic markers in lung cancer.


PubMed | North China Coal Medical College
Type: Journal Article | Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2011

To study the proliferation effect of the AM supernatant incubated activation of p38 mitogen activated protein kinases (p38MAPK) signal transduction pathway in human embryonic lung fibroblasts, and to participate in the development of fibrosis in silicosis.The silicotic alveolar macrophages were collected by bronchoalveolar lavage and incubated in vitro in the DMEM medium containing SiO (50 g/ml) and DMEM medium without SiO for 18 h. Then the AM supernatant incubated for 18 h was collected. HELFs were isolated by organize paste block method, and incubated with AM supernatants. HELFs were divided into four groups: blank control groups, AM groups, SiO + AM groups, SB203580 + SiO + AM groups. The proliferation in the HELF was detected with MTT method and Flow cytometry.The proliferation in the HELF acted with the conditioned AM supernatant fluid were more than blank control groups, AM groups and SB203580 + SiO + AM groups [average optical density: (0.48 0.03) vs (0.29 0.01), (0.38 0.02), (0.33 0.03)], the values with MTT method were statistically different (P < 0.05); Proliferous index with flow cytometry in SiO + AM groups (18.12 0.82) was bigger than blank control groups (9.24 0.48), AM groups (14.76 0.43) and SB203580 + SiO + AM groups (11.71 0.70) and the values were statistically different(P < 0.05).The AM supernatant stimulated by silicon dioxide can accelerate the proliferation in the HELF by activation of p38MAPK signal transduction pathway.

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