Klimenko A.I.,Don State Agrarian University |
Divaeva L.N.,RAS Institute of Chemistry |
Zubenko A.A.,North Caucasian Zonal Scientific Research Veterinary Institute |
Morkovnik A.S.,RAS Institute of Chemistry |
And 2 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2015
Abstract Previously undescribed 2-, 4or 6-substituted hetaryl-3(5)-nitropyridines were synthesized by the interaction of a number of chlorosubstituted 3(5)-nitropyridines with some diazoles or 3-chloropyridazin-6one. In addition, pyrazolyl-3-nitropyridines were prepared by both the above method and cyclization of hydrazinopyridines, which, in turn, were synthesized by the treatment of chlorosubstituted 3-nitropyridines with hydrazine. It has been shown that these compounds have a moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli) and a strong protistocidal effect on protozoa species Colpoda steinii surpassing in this respect clinically used reference drugs. © 2015 Pleiades Publishing, Ltd.