Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMP-29-2015 | Award Amount: 6.33M | Year: 2016
The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2013.4.3-1 | Award Amount: 4.08M | Year: 2014
The CAERUS consortium aims to identify humanitarian relief actions that pave the way for human development and stability in post-conflict societies. Why have some countries successfully escaped the cycle of violence and conflict where others seem to be trapped? What has been the specific role of national, international and particularly European post-conflict relief action and development cooperation in these cases? This project will undertake humanitarian policy analysis on a global and regional scale, examining ways in which these policies support or undermine development and international security. It will also implement population-based studies in key crises-affected areas to obtain field evidence. Research will focus on health and educational policies. Many crises and conflicts entail a substantial degradation in human and social capital, creating barriers to post-conflict recovery and stabilization. The instant re-establishment of access to primary and secondary education, as well as to basic health services, is vital as these are tangible peace dividends. Offering young people real opportunities aside from warfare, and lowering the burden of disease and mortality in war-torn populations dries up the breeding ground of violence and conflict. Moreover, it potentially lowers migratory pressure towards the European Union from post-conflict societies. In addition, the CAERUS project seeks to detect barriers to provision of basic services in post-conflict settings. It will also assess how European technologies, especially field telecommunications and mobile laboratory capacities, can be used to increase timeliness and effectiveness of service provision in remote areas. These activities will, at the same time, increase European capacities to respond to outbreaks of rare and emerging diseases with pandemic potential. The consortium involves partners from Belgium, Norway, the Netherlands, Austria, United Kingdom and India.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SPACE | Award Amount: 5.00M | Year: 2014
MACC-III is the last of the pre-operational stages in the development of the Copernicus Atmosphere Service. Its overall institutional objective is to function as the bridge between the developmental precursor projects - GEMS, PROMOTE, MACC and MACC-II- and the Atmosphere Service envisaged to form part of Copernicus Operations. MACC-III will provide continuity of the atmospheric services provided by MACC-II. Its continued provision of coherent atmospheric data and information, either directly or via value-adding downstream services, is for the benefit of European citizens and helps meet global needs as a key European contribution to the Global Climate Observing System (GCOS) and the encompassing Global Earth Observation System of Systems (GEOSS). Its services cover in particular: air quality, climate forcing, stratospheric ozone, UV radiation and solar-energy resources. MACC-IIIs services are freely and openly available to users throughout Europe and in the world. MACC-III and its downstream service sector will enable European citizens at home and abroad to benefit from improved warning, advisory and general information services and from improved formulation and implementation of regulatory policy. MACC-III, together with its scientific-user sector, also helps to improve the provision of science-based information for policy-makers and for decision-making at all levels. The most significant economic benefit by far identified in the ESA-sponsored Socio-Economic Benefits Analysis of Copernicus report published in July 2006 was the long-term benefit from international policy on climate change. Long-term benefit from air quality information ranked second among all Copernicus benefits in terms of present value. Immediate benefits can be achieved through efficiency gains in relation to current policies. The estimated benefits substantially outweigh the costs of developing and operating the proposed services.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 15.00M | Year: 2015
ENVRIPLUS is a cluster of research infrastructures (RIs) for Environmental and Earth System sciences, built around ESFRI roadmap and associating leading e-infrastructures and Integrating Activities together with technical specialist partners. ENVRIPLUS is driven by 3 overarching goals: 1) favoring cross-fertilization between infrastructures, 2) implementing innovative concepts and devices across RIs, and 3) facilitating research and innovation in the field of environment to an increasing number of users outside the RIs. ENVRIPLUS organizes its activities along a main strategic plan where sharing multi-disciplinary expertise will be most effective. It aims to improve Earth observation monitoring systems and strategies, including actions towards harmonization and innovation, to generate common solutions to many shared information technology and data related challenges, to harmonize policies for access and provide strategies for knowledge transfer amongst RIs. ENVRIPLUS develops guidelines to enhance trans-disciplinary use of data and data-products supported by applied use-cases involving RIs from different domains. ENVRIPLUS coordinates actions to improve communication and cooperation, addressing Environmental RIs at all levels, from management to end-users, implementing RI-staff exchange programs, generating material for RI personnel, and proposing common strategic developments and actions for enhancing services to users and evaluating the socio-economic impacts. ENVRIPLUS is expected to facilitate structuration and improve quality of services offered both within single RIs and at pan-RI level. It promotes efficient and multi-disciplinary research offering new opportunities to users, new tools to RI managers and new communication strategies for environmental RI communities. The produced solutions, services and other project results are made available to all environmental RI initiatives, thus contributing to the development of a consistent European RI ecosystem.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.13M | Year: 2015
ACTRIS-2 addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases capitalizing work of FP7-ACTRIS. ACTRIS-2 aims to achieve the construction of a user-oriented RI, unique in the EU-RI landscape. ACTRIS-2 provides 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and total-column), relevant to climate and air-quality research. ACTRIS-2 develops and implements, in a large network of stations in Europe and beyond, observational protocols that permit harmonization of collected data and their dissemination. ACTRIS-2 offers networking expertise, upgraded calibration services, training of users, trans-national access to observatories and calibration facilities, virtual access to high-quality data products. Through joint research activities, ACTRIS-2 develops new integration tools that will produce scientific or technical progresses reusable in infrastructures, thus shaping future observation strategies. Innovation in instrumentation is one of the fundamental building blocks of ACTRIS-2. Associated partnership with SMEs stimulates development of joint-ventures addressing new technologies for use in atmospheric observations. Target user-groups in ACTRIS-2 comprise a wide range of communities worldwide. End-users are institutions involved in climate and air quality research, space agencies, industries, air quality agencies. ACTRIS-2 will improve systematic and timely collection, processing and distribution of data and results for use in modelling, in particular towards implementation of atmospheric and climate services. ACTRIS-2 invests substantial efforts to ensure long-term sustainability beyond the term of the project by positioning the project in both the GEO and the on-going ESFRI contexts, and by developing synergies with national initiatives.