Temple R.C.,Norwich University |
Hardiman M.,Norfolk Learning Difficulties Service |
Pellegrini M.,Norfolk Learning Difficulties Service |
Horrocks L.,Norfolk Learning Difficulties Service |
Martinez-Cengotitabengoa M.-T.,Norfolk Learning Difficulties Service
Diabetic Medicine | Year: 2011
Aims Maternal diabetes is a recognized risk factor for congenital malformation, perinatal morbidity and obesity in later childhood. The aim of this study is to assess the impact of maternal diabetes on cognitive function in offspring. Methods Participants were 6- to 12-year-old offspring of women with Type1 diabetes. All women received their antenatal care and delivered at one university hospital. HbA 1c was monitored monthly throughout pregnancy and cognitive function was assessed using the Wechsler Intelligence Scale for Children, version4. Results We present results in 40 offspring. There was no difference in overall full-scale IQ compared with UK normative data. However, working memory was poorer than other parts of the Wechsler Intelligence Scale for Children version4 test and significantly lower compared with UK normative data [8.4 (2.2) vs. 10.1 (3.2), P<0.01]. We found no correlation between measurement of digit span or HbA 1c at any stage during pregnancy (r=-0.225 to 0.002), gestational age at delivery (r=-0.178) or infant birthweight ratio (r=-0.176). There was no relationship between working memory score and maternal hypoglycaemia episodes or maternal duration of diabetes. Comparing infants born before (n=9) or after 37weeks' gestation, digit span was non-significantly lower [7.9 (1.8) vs. 8.6 (2.4)]. Discussion These results suggest offspring of women with Type1 diabetes have normal overall cognitive function but poorer working memory. We have been unable to identify specific risk factors. Further larger studies are required to increase the understanding of this memory defect and identify any modifiable risk factors. © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.