Hillerød, Denmark
Hillerød, Denmark

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Eiken P.,Nordsjaellands Hospital | Eiken P.,Copenhagen University | Vestergaard P.,University of Aalborg
Osteoporosis International | Year: 2016

Alendronate (ALN) and risedronate (RIS) are ideal as first-choice therapy options in the treatment of postmenopausal osteoporosis. What to do for patients who do not respond adequately to bisphosphonates has not been conclusively determined, but transitioning to other therapies should be considered. The aim of this article is to describe potential alternatives for patients switching from ALN or RIS to other therapies for osteoporosis. A systematic search of PubMed was conducted to find papers that evaluate the effects of switching therapies on fractures, bone mineral density (BMD), or bone turnover markers. Results from 11 studies that prospectively assessed treatment after ALN or RIS in women with postmenopausal osteoporosis were reviewed. All studies are of short duration (all 24 months or less) and assess the topic of transitioning therapy from ALN or RIS. None of the studies had the statistical power to assess fracture-reduction efficacy. Transitioning from ALN to zoledronic acid maintains therapeutic effects for 12 months. Switching to strontium ranelate, denosumab, or teriparatide causes further increases in BMD. Specifically, transitioning to teriparatide could be used for a limited time for select patients but needs to be followed up with anti-resorptive treatment to prevent a loss of the bone gained. There are only few studies—of short duration—that assess the topic of transitioning therapy from ALN or RIS, although this is a very frequent occurrence in clinical practice. This is especially true if the patient has not reached his/her therapy goal. Further long-term studies are needed. © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation.


Uldum S.A.,Statens Serum Institute | Bangsborg J.M.,Herlev University Hospital | Gahrn-Hansen B.,University of Southern Denmark | Ljung R.,Nordsjaellands Hospital | And 3 more authors.
Eurosurveillance | Year: 2012

Denmark experienced two waves of Mycoplasma pneumoniae infection during autumn and early winter in 2010 and 2011, respectively. Both affected the whole country. The proportion of positive results was almost the same for both, indicating that the two waves were probably of equal size. High macrolide consumption during the epidemics did not seem to affect levels of macrolide resistance in M. pneumoniae, which remain low in Demark (1% to 3%).


Halladin N.L.,Herlev Hospital | Zahle F.V.,Nordsjaellands Hospital | Rosenberg J.,Herlev Hospital | Gogenur I.,Herlev Hospital
Anaesthesia | Year: 2014

Ischaemia of the extremity from the use of a tourniquet and the subsequent reperfusion contribute to the release of reactive oxygen species. This release may result in injury to remote organs. We performed a qualitative systematic review exploring the interventions used to prevent tourniquet-related oxidative damage in adults undergoing orthopaedic surgery, and the possible relationship between biochemical oxidative stress markers and postoperative clinical outcomes. Seventeen randomised controlled studies were included in the qualitative synthesis. Most trials were of low methodological quality and only two studies reported postoperative clinical outcomes. Nine studies tested anaesthetics (propofol, dexmedetomidine, ketamine, and spinal anaesthesia); four studies tested antioxidants (N-acetyl-cysteine, vitamin C, and mannitol); and four studies tested ischaemic pre-conditioning. Fifteen studies showed a significant reduction in biochemical oxidative stress markers. We conclude that propofol and ischaemic pre-conditioning, in particular, appear to show some benefit at reducing oxidative stress following operations under tourniquet; the correlation between a reduction in oxidative stress and postoperative clinical outcomes should be further investigated in the future. © 2014 The Association of Anaesthetists of Great Britain and Ireland.


Nilsson C.,Nordsjaellands Hospital | Sorensen B.L.,Copenhagen University | Sorensen J.L.,Copenhagen University
Acta Obstetricia et Gynecologica Scandinavica | Year: 2014

The objective was to compare two teaching methods for postpartum hemorrhage management: interactive hands-on training and non-interactive video training. In a controlled intervention study at a secondary health care center in Kenya, the two training methods, based on the Advanced Life Support in Obstetrics curriculum, were evaluated utilizing structured observation of a standardized scenario before and after training. Both intervention groups significantly increased in performance scores after receiving hands-on training: 40% (95% CI 29.5-47.0) and video training: 34.5% (95% CI 25.0-42.0); likewise, pass rates improved significantly. No significant differences in performance score or pass rates were found between the two methods. The findings indicate that postpartum hemorrhage management training by mobile media might be just as effective as conventional hands-on training and a feasible way to overcome the outreach gap in sub-Saharan Africa's rural areas, where peripheral health facilities are generally difficult to reach with conventional training programs. © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.


Strandbygaard J.,Copenhagen University | Bjerrum F.,Copenhagen University | Maagaard M.,Copenhagen University | Rifbjerg Larsen C.,Nordsjaellands Hospital | And 2 more authors.
Acta Obstetricia et Gynecologica Scandinavica | Year: 2014

Objective The objective of this study was to develop a four-step curriculum in basic laparoscopy consisting of validated modules integrating a cognitive component, a practical component and a procedural component. Design A four-step curriculum was developed. The methodology was different for each step. Step 1: A 1-day course in basic laparoscopy developed on the background of a regional needs analysis. Step 2: A multiple-choice test, developed and validated through interviews with experts in laparoscopy and subsequently through a Delphi audit involving regional chief physicians. Step 3: A procedural training task (a salpingectomy) on a validated virtual reality simulator. Step 4: An operation on a patient (a salpingectomy) with following formative assessment based on a validated assessment scale. Setting University hospital, Copenhagen, Denmark. Population Fifty-two first-year residents in obstetrics and gynecology from 2009 to 2011. Method Observational cohort study. Main outcome measure Completion rate. Results All participants completed step 1 and improved post-course test scores compared with pre-course test scores, p = 0.001. Step 2 was completed by 75% (37/52); all improved test scores after 6 months, p = 0.001. Step 3 was completed by 75%. Participants used 238 min (range 75-599) and 38 repetitions (range 8-99) to reach proficiency level on a virtual reality simulator. Step 4 was completed by 55%. There was no correlation between test scores and simulator training time. Protected training time was correlated with increasing completion rate. Conclusion A four-step curriculum in basic laparoscopy is applicable in residency training. Protected training time correlated with increasing completion rate. © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.


Sejling A.-S.,Nordsjaellands Hospital | Sejling A.-S.,University of Southern Denmark | Thorsteinsson A.-L.,Nordsjaellands Hospital | Pedersen-Bjergaard U.,Nordsjaellands Hospital | And 3 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2014

Conclusion: This case provides evidence for a causal relationship between SIADH and chronic hyponatremia and impaired bone metabolism that can lead to severe secondary osteoporosis. The effect on bone metabolism is at least partially reversible.The Case: A 38-year-old man had been diagnosed with severe osteoporosis most likely due to chronic SIADH. The SIADH was believed to be idiopathic. A magnetic resonance imaging scan, however, revealed a tumor in the sinus, and biopsies showed an esthesioneuroblastoma, immunohistochemically positive for antidiuretic hormone (ADH). After the tumor was removed, ADH and sodium levels normalized. Adual-energy x-ray absorptiometry scan performed 7months after the patient's last surgery showed a significant spontaneous improvement in bone mineral density in the lumbar vertebrae.Introduction: Recent studies show an association between hyponatremia and osteoporosis. We have previously reported a case of severe male osteoporosis due to chronic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here, we provide a follow-up on this case after cure of the condition that further supports the causal relationship. Copyright © 2014 by the Endocrine Society.


Sorup C.M.,Technical University of Denmark | Jacobsen P.,Technical University of Denmark | Forberg J.L.,Nordsjaellands Hospital
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Year: 2013

Background: Evaluation of emergency department (ED) performance remains a difficult task due to the lack of consensus on performance measures that reflects high quality, efficiency, and sustainability.Aim: To describe, map, and critically evaluate which performance measures that the published literature regard as being most relevant in assessing overall ED performance.Methods: Following the PRISMA guidelines, a systematic literature review of review articles reporting accentuated ED performance measures was conducted in the databases of PubMed, Cochrane Library, and Web of Science. Study eligibility criteria includes: 1) the main purpose was to discuss, analyse, or promote performance measures best reflecting ED performance, 2) the article was a review article, and 3) the article reported macro-level performance measures, thus reflecting an overall departmental performance level.Results: A number of articles addresses this study's objective (n = 14 of 46 unique hits). Time intervals and patient-related measures were dominant in the identified performance measures in review articles from US, UK, Sweden and Canada. Length of stay (LOS), time between patient arrival to initial clinical assessment, and time between patient arrivals to admission were highlighted by the majority of articles. Concurrently, " patients left without being seen" (LWBS), unplanned re-attendance within a maximum of 72 hours, mortality/morbidity, and number of unintended incidents were the most highlighted performance measures that related directly to the patient. Performance measures related to employees were only stated in two of the 14 included articles.Conclusions: A total of 55 ED performance measures were identified. ED time intervals were the most recommended performance measures followed by patient centeredness and safety performance measures. ED employee related performance measures were rarely mentioned in the investigated literature. The study's results allow for advancement towards improved performance measurement and standardised assessment across EDs. © 2013 Sørup et al.; licensee BioMed Central Ltd.


We present two cases in which the patients were admitted to a local hospital with acute abdominal pain four or five months after having undergone laparoscopic gastric bypass. In both cases, operation revealed a perforation of the small bowel close to the distal anastomosis. In the first case, a massive constipation of the small bowel was most likely a contributing factor. In the second case, the cause was a kink of the entero-entero anastomosis leading to obstruction and finally perforation of the biliary limp. Late perforations are among the rarely reported complications associated with gastric bypass but as our two cases illustrate they are important to keep in mind.


Philipsen J.P.,Nordsjaellands Hospital | Madsen K.V.,Metropolitan University of Technology
Scandinavian Journal of Clinical and Laboratory Investigation | Year: 2015

Introduction. Automated hematology analyzers dilute patient erythrocytes with an isoosmotic diluent before quantitating the erythrocyte mean cell volume (MCV). However, if patient plasma osmolality differs from the diluent, water will cross the erythrocytes membrane and establish a new equilibrium across the membrane. Since the new equilibrium is reached before the measurement of the MCV, the measured MCV may not reflect the true MCV in vivo. Aim. Calculation of the theoretical change in MCV at changed P-Sodium/P-Osmolality and to investigate if the automated blood cell counter Sysmex XE 2100 measures MCV correctly in hypo- and hyperosmolality and hypo-and hypernatremia. In addition, to examine whether the theoretically calculated change in MCV corresponds with the experimentally determined MCV change. Method. Theoretical calculation of the MCV inaccuracy at hypo- and hypernatremia, as well as at hypo- and hyperosmolality. Experimental studies with comparison of MCV measured at Sysmex XE 2100 to MCV found by using the manual measured packed cell volume method. Results and conclusion. Measurement of MCV in hypo- and hypernatremia patients using the automated blood cell counter Sysmex XE 2100 resulted in inaccurate MCV. The experimental results also revealed a strong correlation between P-Osmolality/P-Sodium and MCV inaccuracy (R2 = 0.70/0.85) similar to the theoretically calculated MCV inaccuracy. We suggest using mean cellular Hb (MCH) instead of MCV, mean corpuscular Hb concentration (MCHC) and B-Erythrocyte volume fraction (EVF). Alternatively, we suggest standardizing the measured MCV to a normal P-Sodium e.g. 140 mmol/L to estimate the in vivo MCV. © 2015 Informa Healthcare.


Heiring C.,Nordsjaellands Hospital | Steensberg J.,Neonatalklinikken 5021 | Bjerager M.,Nordsjaellands Hospital | Greisen G.,Nordsjaellands Hospital
Neonatology | Year: 2015

Background: Nasal continuous positive airway pressure (nCPAP) stabilizes the residual volume and may decrease the risk of 'atelectotrauma', potentially promoting lung development in neonates. Objectives: To assess whether replacing nCPAP by low-flow O2 by nasal cannula affects lung function expressed as the arterial/alveolar oxygen tension ratio (a/A pO2 ratio) on postnatal day 28. Methods: Preterm infants (birth weight <1,500 g and gestational age, GA >26 + 0 weeks) stable on nCPAP between postnatal days 4 and 7 were randomized to nCPAP or low-flow O2 by nasal cannula (<0.2 liters/min). Study criteria defined how to wean/restart respiratory support or change from low-flow O2 to nCPAP and vice versa. Transcutaneous monitoring was used for the assessment of the a/A pO2 ratio on day 28 using a head box for all infants for accurate measurement and to eliminate possible effects from nCPAP or low-flow O2 on oxygen requirement. Results: We enrolled 52 infants (nCPAP group n = 30 and low-flow O2 group n = 22). The a/A pO2 ratio at 28 days was 0.43 ± 0.17 (nCPAP group) versus 0.48 ± 0.18 (p = 0.36). The duration of nCPAP was 16.4 (low-flow group) versus 41.1 days (nCPAP group), p < 0.001. There was no difference between groups in the fraction needing any respiratory support at 36 weeks' corrected age, length of stay, weight at discharge, and relative weight gain. Conclusions: Replacing nCPAP by low-flow O2 in preterm infants with GA >26 weeks at the end of the first week of life did not seem to affect the a/A pO2 ratio or weight gain negatively. Thus, prolonged nCPAP seems not to have a positive effect on lung function at 28 days of life and replacement by low-flow O2 could reduce the cost of equipment and increase the ease of nursing. © 2015 S. Karger AG, Basel.

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