Noida Institute of Engineering and Technology
Greater Noida, India

Noida Institute of Engineering and Technology is a college of engineering in Greater Noida, Uttar Pradesh, India. Wikipedia.

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Garg S.,Amity Institute of Applied science | Chandra A.,Amity University | Mazumder A.,Noida Institute of Engineering and Technology | Mazumder R.,Noida Institute of Engineering and Technology
Asian Journal of Pharmaceutics | Year: 2014

The present study reports wound healing potential of silver nanoparticles (AgNPs) hydrogel using Arnebia nobilis (A. nobilis) root extract. It makes a convenient method for the green synthesis of AgNPs and evaluated for its wound healing activity. Silver has been used for the treatment of medical ailments for over 100 years due to its natural antibacterial and antifungal properties. The synthesized nanoparticles were characterized using UV-visible spectrophotometer; transmission electron microscopy, X-ray diffraction (XRD), scanning electron microscopy, and Fourier transform infra-red spectrometry. The nanoparticles were found to be mostly spherical in shape. XRD study shows that the particles are crystalline in nature with face centered cubic geometry. The synthesized AgNPs exhibited good antibacterial potential against both Gram-positive and Gram-negative bacterial strain as measured using well diffusion assay. The recent emergence of nanotechnology has provided a new therapeutic modality in AgNPs for use in wounds. We investigated the wound-healing potential of AgNPs hydrogel using A. nobilis root extract in an excision animal model. The study showed that hydrogel of AgNPs using A. nobilis root extract exert positive effect due to their antimicrobial potential. The results provide insight into the mechanism of actions of AgNPs and have provided a novel therapeutic direction for wound treatment in the clinical practice.

Mohan A.,Noida Institute of Engineering and Technology
Indian Drugs | Year: 2010

Recent developments in technology have presented viable dosage alternatives for pediatric, geriatric, bedridden, nauseous or non-compliant patients. Traditional tablets and capsules administered with 250 mL of water may be inconvenient or impractical for such patients. Hence, fast dissolving/ disintegrating dosage form (FDDS) is a perfect fit for them. FDDS dissolve or more commonly disintegrate rapidly in the saliva without the aid of water. Also, this dosage form offers an advantage of convenience of administration while travelling where they may not have an access to water. Fast dissolving tablets have come a long way since the time the technology first emerged. Today many drugs are being formulated and marketed as fast dissolving dosage forms. Even the future of this technology seems to be very promising.

Asamenew G.,Addis Ababa Institute of Technology | Bisrat D.,Addis Ababa Institute of Technology | Mazumder A.,Noida Institute of Engineering and Technology | Asres K.,Addis Ababa Institute of Technology
Phytotherapy Research | Year: 2011

In the search for new antimicrobial and antioxidant compounds from plants, the latex of the medicinal plant Aloe harlana Reynolds from Ethiopia was subjected to bioassay-guided fractionation, which led to the isolation of two known compounds, anthrone (aloin) and chromone (7-O-methylaloeresin A). The latex and its two constituents were assessed for their possible antimicrobial activities against 23 bacterial and four fungal strains using the disc diffusion method and their antioxidant activity by two complementary test systems, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2-deoxyribose degradation assay methods. The isolated compounds showed promising results against various pathogenic bacterial and fungal strains in comparison with standard drugs. Moreover, 7-O-methylaloeresin A exhibited good activity against multiple drug resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255) with MIC values of 0.72 and 0.18 mm, respectively. Among the fungal strains tested, Candida albicans (ATCC 10231) was the most susceptible organism to the latex and the two isolated compounds. The latex and isolated compounds also showed significant activities on both antioxidant assays with the highest activity being observed for 7-O-methylaloeresin A, which gave IC 50 values of 0.026 mm and 0.021 mm for DPPH and 2-deoxyribose degradation assay, respectively. These findings support the traditional uses of the plant for the treatment of various infectious and inflammatory diseases. Copyright © 2011 John Wiley & Sons, Ltd.

Yadav P.,Noida Institute of Engineering and Technology | Majee C.,Noida Institute of Engineering and Technology
International Journal of PharmTech Research | Year: 2015

Objective: to develop and validate a new very rapid, sensitive, reverse phase Ultra Performance Liquid Chromatography (RP-UPLC) technique for the estimation of Propranolol Hydrochloride in dosage form, as there is no official monograph & no analytical method by UPLC. Methodology: Chromatographic separation was achieved on a Waters Acquity BEH C18 column (30 x 2.1 mm, 1.7μm) using a gradient method with mobile phase composed of trifluoroacetic acid (0.1%) and acetonitrile in the ratio 80:20 v/v. The flow rate was 0.3 ml/min, temperature of the column was maintained at ambient and detection was made at 230 nm. The run time was as short as 2.5 min. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness. Results: The developed method was linear for Propranolol Hydrochloride from 10 - 50 μg/ml and the linear regression obtained was > 0.999. Precision, evaluated by intra- and inter-day assays had relative standard deviation (R.S.D) values within 0.72%. Recovery data were in the range 96.70 to 98.72%. Conclusion: The method is precise, accurate, linear, robust and fast. The short retention time of 0.98 min allows the analysis of a large number of samples in a short period of time and, therefore, should be cost-effective for routine analysis in the pharmaceutical industry. © 2014 International Journal of PharmTech Research.

Poonam S.,Noida Institute of Engineering and Technology | Chandana M.,Noida Institute of Engineering and Technology
International Journal of PharmTech Research | Year: 2015

Cancer is a major public health burden in both developed and developing countries. It is an abnormal growth of cells in body that can lead to death and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. Many natural products and their analogues have been identified as potent anti-cancer agents and day by day the anticancer property of various plants is being identified. New drug discovery is time consuming & laborious process. So the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance & solubility & metabolic limitations can be overcome by appropriate molecular modification. Medicinal plants with their isolated lead molecules are also used as an alternative medicine for treating neoplastic cells. Neoplastic cells are the anomalous proliferation of cells in the body which cause cancer. Diverse efficient compounds derived from natural products have been isolated as anticancer agents. There chemical compounds are formulated with a view to create effective drugs against cancer. © 2015, Sphinx Knowledge House. All rights reserved.

Bhushan R.K.,Shri Mata Vaishno Devi University | Kumar S.,Noida Institute of Engineering and Technology
Journal of Materials Engineering and Performance | Year: 2011

The stir casting method was used for fabrication of 7075 aluminum alloy with 10 wt.% SiC particles of size 20-40 μm. The research objective of this paper are to achieve uniform distribution of SiC particles in the 7075 aluminum alloy matrix, characterization, and analysis of mechanical properties of composite formed. Experiments were carried out at stirring speeds of 500, 650, 750 rpm, and stirring period of 10 min. Microstructures of aluminum alloy and composites with 5, 10 wt.% SiC reinforcements were examined. The results reveal that composite produced at stirring speed of 650 rpm and stirring time of 10 min has uniform distribution of SiC particles. XRD and EDAX analysis were carried out for 7075 Al alloy and composite with 10 wt.% SiC reinforcement. No adverse reaction was observed in XRD and EDAX of composite with 10 wt.% SiC reinforcement. Tensile strength and hardness increased by 12.74% and 10.48%, respectively, with the increase in percentage of SiC reinforcement from 5 to 15 wt.%. © 2010 ASM International.

Sharma S.,Mewar University | Dwivedi V.K.,Galgotias University | Pandit S.N.,Noida Institute of Engineering and Technology
International Journal of Green Energy | Year: 2014

Thermoelectric devices are solid-state devices. Semi-conductor thermoelectric power generation, based on the Seebeck effect, and semi-conductor thermoelectric cooling, based on the Peltier effect, have interesting capabilities compared to conventional power generation and cooling systems. The absence of moving components results in increase in reliability, a reduction in maintenance, and an increase of system life; the modularity allows for application in wide range without significant losses in performance; the absence of working fluid avoids environmental dangerous leakages; and the noise reduction appears also to be an important feature. With the rapid development of techniques to make excellent semi-conductor materials the practical applications and theoretical investigations of the thermoelectric devices have come into focus. This article begins with a brief overview of thermoelectric technology, thermoelectric materials, thermoelectric module construction and operation. A review of recent developments in research, commercial development, and typical applications of thermoelectric devices is made. The article draws conclusions on the development and potential application of thermoelectric devices suitable for thermoelectric cooling. © Taylor & Francis Group, LLC.

Kumar S.,Noida Institute of Engineering and Technology
Journal of the Brazilian Society of Mechanical Sciences and Engineering | Year: 2015

In this experimental study, an attempt has been made to optimize the process parameters of friction stir welding (FSW) for tensile strength and percentage elongation using Taguchi-based gray relation analysis (GRA). An orthogonal array of L9 has been implemented to fabrication of joints. The experiments have conducted according to the combination of rotational speed, tool tilt (TLT) and types of tool pin profile (TPP). The results revealed that the rotational speed is most significant process parameter with percentage contribution of 96.24 %. On optimization, tool rotation speed of 1,550 rpm, TLT angle of 4° and octagonal-type TPP have been found to be the best parameter setting for FSW process of aluminum 6061 and 6082 alloy welds. To ensure the robustness of GRA, a confirmation test was performed at selected optimal process parameter setting. © 2014, The Brazilian Society of Mechanical Sciences and Engineering.

Kumar S.,Noida Institute of Engineering and Technology | Singh M.P.,Dr. B.R. Ambedkar University
Applied Soft Computing Journal | Year: 2012

In this paper we are studying the performance of Hopfield neural network for recalling of memorized patterns from the Hebbian rule and genetic algorithm for English characters. In this process the genetic algorithm is employed in random form and sub-optimal form for recalling of memorized patterns corresponding to the presented noisy prototype input patterns. The objective of this study is to determine the optimal weight matrix for correct recalling corresponding to noisy form of the English characters. In this study the performance of neural network is evaluated in terms of the rate of success for recalling of noisy input patterns of the English characters with GA in two aspects. The first aspect reflects the random nature of the GA and the second one exhibits the suboptimal nature of the GA for its exploration. The simulated results demonstrate the better performance of network for recalling of the stored letters of English alphabets using genetic algorithm on the suboptimal weight matrix. © 2012 Elsevier B.V.

Dwivedi S.P.,Noida Institute of Engineering and Technology
Journal of Mechanical Science and Technology | Year: 2014

In the present investigation, A356/C355 aluminium alloys are welded by friction stir welding by controlling various welding parameters. A356 and C355 aluminium alloys materials have a set of mechanical and physical properties that are ideally suited for application in aerospace and automobile industries and not widely used because of its poor weldebility. To overcome this barrier, weldebility analysis of A356 and C355 aluminium alloys with high speed steel (Wc-Co) tool has been investgated. An attempt has been made to investigate the influence of the rotational speed of the tools, the axial force and welding speed on tensile strength of A356/C355 aluminium alloys joint. The experiments were conducted on a milling machine. The main focus of investigation is to determine good tensile strength. Response surface methodology (box Behnken design) is chosen to design the optimum welding parameters leading to maximum tensile strength. The result shows that axial force increases, tensile strength decreases. Whereas tool rotational speed and welding speed increase, tensile strength increases. Optimum values of axial force (3 /KN), tool rotational speed (900 RPM) and welding speed (75 mm/min.) during welding of A356/C355 aluminium alloys joint to maximize the tensile strength (Predicted 223.2 MPa) have been find out. © 2014 The Korean Society of Mechanical Engineers and Springer-Verlag Berlin Heidelberg.

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