Noble College

Machilīpatnam, India

Noble College

Machilīpatnam, India
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Chavakula R.,Vishnu Institute of Technology | Chintala R.,Acharya Nagarjuna University | Tadanki B.,Noble College
Journal of Pharmacy Research | Year: 2013

Aim: To develop and validate the stability indicating high performance liquid chromatography method for simultaneous estimation of Metronidazole and Norfloxacin in combined dosage form. Materials and methods: The chromatographic separation was obtained by using a mobile phase composition at a ratio of 82:18 (v/v) of buffer pH 4.0 and Acetonitrile on Symmetry Hypersil C18 column (150×4.6mm, 5μm) with UV detection at 290nm at a flow rate of 1ml/min. Results: The retention time were found to be 2.3 and 3.4min for Metronidazole and Norfloxacin respectively. The linearity of developed method was tested in the range of 75-175μg/ml for Metronidazole and 60-140μg/ml for Norfloxacin with correlation coefficients 0.999. The Limit of detection was 0.005 and 0.0025 gmL-1 and the quantification limit was 0.017 gmL-1 and 0.00875gm L-1 for Metronidazole and Norfloxacin respectively. The accuracy of the proposed method was determined by recovery studies and found to be 101.04% for Metronidazole and 99.92% for Norfloxacin. The degradation peaks are well resolved from the main peaks. Conclusion: The proposed stability indicating HPLC method for the simultaneous determination of Metronidazole and Norfloxacin in tablet dosage form was accurate, rapid, precise, linear, simple, economic, and robust. The developed method may be used for analysis of stability samples of Metronidazole and Norfloxacin in quality control laboratory. © 2013 JPR Solutions.

Sudharsan Reddy Y.,Sri Venkateswara University | Manjulatha V.,Noble College | Varma S.V.K.,Sri Venkateswara University | Raju V.C.C.,University of Botswana
Advances and Applications in Fluid Mechanics | Year: 2015

In this paper, the effects of radiation and chemical reaction on MHD oscillatory flow of an optically thin fluid in an asymmetric channel filled with porous medium are investigated. Based on some simplifying assumptions, the dimensionless governing equations are solved analytically using regular perturbation method. The effects of various pertinent parameters such as radiation parameter (N), Peclet number (Pe), chemical reaction parameter (K1), Reynolds number (Re), Schmidt number (Sc), magnetic field parameter (M), porous medium shape factor (S), thermal Grashof number (Gr), solutal Grashof number (Gm) and geometric parameters like phase difference (ϕ), amplitude ratios (a and b), mean half width of the channel (d), phase angle (ωt) on concentration, temperature and velocity are discussed numerically and explained graphically. The shear stress, rate of heat and mass transfer coefficients at the channel walls are also derived. It has been found that the flow parameters considerably affect the flow characteristics. © 2015 Pushpa Publishing House, Allahabad, India.

Manjulatha V.,Noble College | Varma S.V.K.,Sri Venkateswara University | Raju V.C.C.,University of Botswana
Advances and Applications in Fluid Mechanics | Year: 2013

This paper investigates the effects of radiation and chemical reaction on the unsteady MHD oscillatory flow of viscous, incompressible, electrically conducting, optically thin fluid in a channel filled with saturated porous medium in the presence of an aligned magnetic field. © 2013 Pushpa Publishing House.

Telia E.D.,Noble College | Taherunnisa M.,Noble College | Deepthi G.K.,Amrita Sai Institute of Science and Technology | Choragudi B.M.,Sujay Bio Technology Pvt. Ltd. | Choragudi B.R.,Noble College
Rasayan Journal of Chemistry | Year: 2011

The oxidative coupling of the proposed method is simple, rapid and sensitive with reasonable precision and accuracy. The precision of the method was found by analyzing a set of eight solutions, each containing a final concentration value approximately in the middle of die Beer's law range. The percent relative standard deviation in method is presented in Table-2. The accuracy of the method was determined by taking different known amounts (within Beer's law limits) of the drug and analyzing them by proposed method. The results are given in Table - 3. In the determination of tetracyclines the excipients usually present in formulations (glucose, starch, sodium hexaphosphate and some vitamins) and the other antibiotics such as cycloserline, streptomycin lidocaine or penicillins did not interfere. © 2011 RASAYAN. All rights reserved.

Benjamin T.,Noble College | Rajyalakshmi C.,Vishnu Institute of Technology | Rambabu C.,Acharya Nagarjuna University
International Journal of ChemTech Research | Year: 2013

A Stability indicating reverse phase high performance liquid chromatography method has been developed for the estimation of Aprepitant in tablet dosage form. A Thermosil symmetry C18 column having dimensions of 150×4.6mm and 5μm particle size, with mobile phase containing a mixture of water and Acetonitrile in the ratio of 30:70 v/v was used. The flow rate was 1ml/min and the column effluents were monitored at 220 nm. The retention time for Aprepitant was found to be 2.8 min. The proposed method was validated in terms of linearity, accuracy, precision, LOD, LOQ and robustness. The LOD and LOQ were found to be 0.085μg/ml and 0.28μg/ml respectively. The method was found to be linear in the range of 50 - 90 μg/ml with regression coefficient (r=0.999). The % recovery for the Aprepitant was found to be 100.7 and the forced degradation studies were also carried out as per ICH guidelines. There was complete separation of degradation and Aprepitant peak, which demonstrate the specificity of assay method for estimation of Aprepitant in the presence of its degradation products and it can be employed as a stability indicating one. Due to simplicity, rapidity and accuracy of the proposed stability indicating HPLC method and it is useful for quality control analysis.

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