No422 Hospital Of Pla

Zhanjiang, China

No422 Hospital Of Pla

Zhanjiang, China
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Li Y.,Southwest University | Li Y.,No422 Hospital Of Pla | Fan L.,No 210 Hospital Of Plaliaoning | Niu Y.,Northwestern Polytechnical University | And 6 more authors.
European Journal of Pharmacology | Year: 2017

Treatment of colorectal cancer (CRC) remains a clinical challenge, since current therapies are associated with obvious side effects and high expenses. These limitations highlight an urgent need for developing novel and safe treatment strategies. It is suggested that combinatorial strategies could be more effective and much safer than monotherapy in cancer treatment. In our previous study, an apple oligogalactan (AOG) has been found to show beneficial effect on treating CRC. This study tried to investigate whether AOG could enhance the growth inhibitory effect of 5-FU in human CRC cells (HT-29 and SW-620), a mouse model of colitis associated colorectal cancer and a murine model of xenograft tumor. The IC50 values of 5-FU were 26.70±0.21 μM in HT-29 cells and 26.71±2.06 μM in SW-620 cells. Pretreatment with 0.05 or 0.1 mM AOG down-regulated IC50 values of 5-FU to 22.44±1.01 or 18.67±1.16 μM in HT-29 and 21.21±1.49 or 17.99±1.42 μM in SW-620 cells. AOG enhanced 5-FU-induced cell apoptosis and S phase arrest. The combination not only protected ICR mice against intestinal toxicities and carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate, but also decreased the xenograft tumor size, triggered apoptosis and inhibited proliferation of tumor cells in nude mice. The mechanisms of AOG on enhancing the growth inhibitory effect of 5-FU may be through the influence of TLR-4/NF-κB pathway. Taken together, the combinatorial therapy using AOG and 5-FU is a promising strategy for the treatment of colorectal cancer. © 2017 Elsevier B.V.


Tian C.-O.,Shanghai University | Tian C.-O.,No422 Hospital Of Pla | Yang Z.-G.,Shanghai University | Zhang L.,Shanghai University | And 6 more authors.
Academic Journal of Second Military Medical University | Year: 2015

To discuss the clinical value of diluted contrast enhanced Dyna CT in evaluating direct carotid-cavernous fistula(DCCF). Methods The clinical data of 16 patients with traumatic and solo fistulous DCCF were retrospectively studied. The images by 3D rotatory digital subtraction angiography (3D-DSA) and diluted contrast enhanced Dyna CT were used for comparison and analysis of their values for diagnosis of DCCF. The comparison items included information on the orificium fistulae, the retrograde leptomeningeal venous drainage (RLVD), the draining veins and the compartment of the cavernous sinus. Results Compared with 3D rotatory DSA, Dyna CT demonstrated 21 more findings in 15 patients (93.75%), including the detection of the orificium fistulae (n=8), the RLVD (n=2), the draining veins (n=2), and compartment of the cavernous sinus (n=9), with significant difference found between Dyna CT and 3D-DSA in revealing the orificium fistulae and compartment of the cavernous sinus (P<0.05), while not in revealing RLVD and the draining veins. Conclusion Compared with 3D-DSA, Dyna CT can more effectively demonstrate the orificium fistulae and compartment of the cavernous sinus of DCCF, which may benefit the clinical diagnosis and treatment of DCCF. © 2015, Second Military Medical University Press. All rights reserved.


Xu H.,No422 Hospital Of Pla | Zhou C.,No422 Hospital Of Pla | Li Y.,No422 Hospital Of Pla | Zou W.,No422 Hospital Of Pla | And 2 more authors.
Cancer Research and Clinic | Year: 2014

Objective: To comparative analyze the anorectal function before and after anus-preserving laparoscopic rectal resection in ultra low rectal cancer. Methods: Radical excision of ultra low rectal cancer was performed with ultrasonic scalpel on 43 patients based on the concept of TME and ultra low colorectal/anal anastomosis was perfomed by applying the manual anastomosis with two operations out of anus. The time of guid being controlled in the rectus, rectual rest pressure (RRP), anal rest pressure (ARP) and anal maximal contraction pressure (AMCP) were tested before operation. The function of their rectus and anus was tested, including the number of bowel movement in one day of 1, 3, 6 months after operation, the time of guid being controlled in the rectus, RRP, ARP and AMCP after 3, 6 months of operation et al. Results: All the operations were finished successfully, four cases were converted to open surgery, but there was no serious damage. All cases were followed up for 6 to 36 months with average of 20 months. After 3 months of operation, the retention time of liquid in rectus, the defecate feel function, the anus control function, RRP and ARP was statistically significant (P < 0.05) compared to them before operation, there was no statistical significance (including AMCP) (P > 0.05) after 6 months of operation.The results of tests in annus and rectus were near normal level after 6 month of operation. Conclusion: The manual anastomosis with two operations out of anus in the laparoscopic anal sphincter preserving resection of ultra low rectal cancer is safe, economical ,effective,minimally invasive and shorter hospital stay, it is worth to be widely used.

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