Taian, China
Taian, China

Time filter

Source Type

Li Z.-F.,No 88 Hospital Of Pla | Guo Z.-F.,Shanghai University | Yang S.-G.,No 88 Hospital Of Pla | Zheng X.,Shanghai University | And 2 more authors.
Regulatory Peptides | Year: 2010

Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. We investigated fasting plasma ghrelin and obestatin levels and ratio of ghrelin to obestatin in humans with untreated mild-to-moderate hypertension and humans with normal blood pressure. We found that the plasma concentration of ghrelin and the ratio of ghrelin to obestatin were significantly lower in hypertension group compared with control group (236.3 ± 12.3. pg/ml vs 381.4 ± 25.6. pg/ml, P< 0.01; 0.89 ± 0.06 vs 1.2 ± 0.06, P< 0.01). The plasma concentration of obestatin was lower in hypertension group compared with control group, but the difference between the two groups was not significant (276.2 ± 15.1. pg/ml vs 325.4 ± 25.8. pg/ml, P> 0.05). In a multiple regression model, systolic blood pressure, triglyceride and obestatin were independent predictors of ghrelin (standardized coefficient = -0.332; P= 0.019; standardized coefficient = -0.302; P= 0.030; standardized coefficient = 0.630; P< 0.0005, respectively). In another multiple regression model, only ghrelin was an independent predictor of obestatin (standardized coefficient = 0.861; P< 0.0005). Both systolic blood pressure and triglyceride were independent predictors of ratio of ghrelin to obestatin (standardized coefficient = -0.385; P= 0.033; standardized coefficient = -0.430; P= 0.018, respectively). Our data suggests that there are disturbances of ghrelin and obestatin in the circulating plasma of humans and the ghrelin/obestatin system might play a role in blood pressure regulation. © 2010 Elsevier B.V.


Wang Y.,No 88 Hospital Of Pla | Yang Y.-C.,Shanghai University | Lan D.-M.,Shanghai University | Wu H.-J.,Shanghai University | Zhao Z.-X.,Shanghai University
Sleep and Breathing | Year: 2016

Purpose: Sleep disturbance is common in Parkinson’s disease (PD) and negatively impacts quality of life. There is little data on how dopamine agonists influence nocturnal sleep in PD, particularly in sleep laboratory data to measure sleep parameters and their changes objectively. The goal of this open-label study was to objectively evaluate the effect of rotigotine on sleep in PD patients by video-polysomnographic methods. Methods: A total of 25 PD patients with complaints of nocturnal sleep impairment were enrolled. The sleep quality before and after stable rotigotine therapy was evaluated subjectively through questionnaire assessments and objectively measured by video-polysomnographic methods. The Parkinsonism, depression, anxiety, and quality of life of PD patients were also evaluated through questionnaire assessments. Results: At the end of rotigotine treatment, the PD daytime functioning, motor performance, depression, subjective quality of sleep, and the quality of life improved. Video-polysomnographic analysis showed that the sleep efficiency and stage N1% were increased, while the sleep latency, wake after sleep onset, and the periodic leg movements in sleep index were decreased after rotigotine treatment. Conclusions: Video-polysomnographic analysis confirmed the subjective improvement of sleep after rotigotine treatment. This observation suggests that in PD rotigotine is a treatment option for patients complaining from sleep disturbances. © 2016 Springer-Verlag Berlin Heidelberg


PubMed | Shanghai University and No 88 Hospital Of Pla
Type: | Journal: Sleep & breathing = Schlaf & Atmung | Year: 2016

Sleep disturbance is common in Parkinsons disease (PD) and negatively impacts quality of life. There is little data on how dopamine agonists influence nocturnal sleep in PD, particularly in sleep laboratory data to measure sleep parameters and their changes objectively. The goal of this open-label study was to objectively evaluate the effect of rotigotine on sleep in PD patients by video-polysomnographic methods.A total of 25 PD patients with complaints of nocturnal sleep impairment were enrolled. The sleep quality before and after stable rotigotine therapy was evaluated subjectively through questionnaire assessments and objectively measured by video-polysomnographic methods. The Parkinsonism, depression, anxiety, and quality of life of PD patients were also evaluated through questionnaire assessments.At the end of rotigotine treatment, the PD daytime functioning, motor performance, depression, subjective quality of sleep, and the quality of life improved. Video-polysomnographic analysis showed that the sleep efficiency and stage N1% were increased, while the sleep latency, wake after sleep onset, and the periodic leg movements in sleep index were decreased after rotigotine treatment.Video-polysomnographic analysis confirmed the subjective improvement of sleep after rotigotine treatment. This observation suggests that in PD rotigotine is a treatment option for patients complaining from sleep disturbances.


PubMed | Binzhou Medical University, PLA Fourth Military Medical University and No 88 Hospital Of Pla
Type: Journal Article | Journal: Oncotarget | Year: 2016

Tumour self-seeding by circulating tumour cells (CTCs) enhances tumour progression and recurrence. Previously, we demonstrated that tumour self-seeding by CTCs occurs in osteosarcoma and revealed that interleukin-6 (IL-6) may promote CTC attraction. Here, we investigated the underlying mechanisms of IL-6 in tumour self-seeding by CTCs. IL-6 suppression inhibited in vitro cell proliferation, migration, and invasion. In addition, rhIL-6 activated the Janus-activated kinase/signal transducers and activators of transcription 3 (JAK/STAT3) and mitogen-activated protein kinase/extracellular-signal regulated kinase1/2 (MAPK/ERK1/2) pathways in vitro. Both pathways increased cell proliferation, but only the JAK/STAT3 pathway promoted migration. Suppressing IL-6 inhibited in vivo tumour growth and metastasis. IL-6 suppression or JAK/STAT3 pathway inhibition reduced CTC seeding in primary tumours. Collectively, IL-6 promotes tumour self-seeding by CTCs in a nude mouse model. This finding may provide a novel strategy for future therapeutic interventions to prevent osteosarcoma progression and recurrence.


Wang L.-J.,Xi'an Jiaotong University | Zhang K.-L.,No 88 Hospital Of Pla | Zhang N.,No 202 Hospital Of Pla | Ma X.-W.,No 202 Hospital Of Pla | And 3 more authors.
Oncotarget | Year: 2015

In order to determine the diagnostic and prognostic value of miR-26a in Cholangiocarcinoma (CCA), we compared miR-26a levels in serum from 66 CCA patients and 66 healthy controls, which was followed by serum analysis between the pre-operative serum and post-operative serum of these CCA patients. We found the concentration levels of miR-26a in serum of CCA patients were significantly higher than that from healthy controls (P < 0.01). Furthermore, the concentration levels of miR-26a in the post-operative serum were significantly reduced when compared to the pre-operative serum (P < 0.001). High miR-26a in serum was correlated significantly with clinical stage, distant metastasis, differentiation status, and poor survival of CCA patients. More importantly, serum miR-26a was an independent prognostic marker for CCA. In conclusion, our results suggested that miR-26a in serum might be a potential and useful noninvasive biomarker for the early detection of CCA.


PubMed | Xi'an Jiaotong University, No 88 Hospital Of Pla and No 202 Hospital Of Pla
Type: Journal Article | Journal: Oncotarget | Year: 2015

In order to determine the diagnostic and prognostic value of miR-26a in Cholangiocarcinoma (CCA), we compared miR-26a levels in serum from 66 CCA patients and 66 healthy controls, which was followed by serum analysis between the pre-operative serum and post-operative serum of these CCA patients. We found the concentration levels of miR-26a in serum of CCA patients were significantly higher than that from healthy controls (P < 0.01). Furthermore, the concentration levels of miR-26a in the post-operative serum were significantly reduced when compared to the pre-operative serum (P < 0.001). High miR-26a in serum was correlated significantly with clinical stage, distant metastasis, differentiation status, and poor survival of CCA patients. More importantly, serum miR-26a was an independent prognostic marker for CCA. In conclusion, our results suggested that miR-26a in serum might be a potential and useful noninvasive biomarker for the early detection of CCA.


Li Z.-F.,Fudan University | Li Z.-F.,No 88 Hospital Of Pla | Zhou D.-X.,Fudan University | Wang Q.-B.,Fudan University | And 3 more authors.
Regulatory Peptides | Year: 2013

N-terminal pro-brain natriuretic peptide (NT-proBNP), a pro-hormone secreted by the myocardium in response to various stimuli, was found to be correlated with several hemodynamic parameters in pulmonary hypertension associated with systemic sclerosis. We investigated plasma NT-proBNP levels and the relationships between NT-proBNP and several hemodynamic parameters in atrial septal defect (ASD) patients with or without pulmonary arterial hypertension (PAH). We found that plasma NT-proBNP level was significantly higher in PAH group compared with the control group (5495.4. ±. 388.4 pg/ml vs 4005.1 ± 260.5 pg/ml, P< 0.05). In a multiple regression model analysis, only mean pulmonary arterial pressure was an independent predictor of NT-proBNP (standardized coefficient = 0.663, P= 0.002). In the PAH group, only right atrial systolic pressure was found to be positively correlated with NT-proBNP, whereas other parameters were not found to be correlated with NT-proBNP. Our data suggests that NT-proBNP might also be a predictor of the severity of pulmonary hypertension in the ASD patients. © 2013.


Wang L.,State Key Laboratory of Cancer Biology | Guo Z.-Y.,PLA Fourth Military Medical University | Zhang R.,State Key Laboratory of Cancer Biology | Xin B.,No 88 Hospital Of Pla | And 7 more authors.
Carcinogenesis | Year: 2013

The POU transcription factor OCT4 is a pleiotropic regulator of gene expression in embryonic stem cells. Recent studies demonstrated that OCT4 is aberrantly expressed in multiple types of human cancer; however, the underlying molecular mechanism remains largely unknown. In this study, we report that OCT4-pg4, a pseudogene of OCT4, is abnormally activated in hepatocellular carcinoma (HCC). The expression level of OCT4-pg4 is positively correlated with that of OCT4, and both gene transcripts can be directly targeted by a tumor-suppressive micro RNA miR-145. We find that the non-coding RNA OCT4-pg4 is biologically active, as it can upregulate OCT4 protein level in HCC. Mechanistic analysis revealed that OCT4-pg4 functions as a natural micro RNA sponge to protect OCT4 transcript from being inhibited by miR-145. In addition, our study also showed that OCT4-pg4 can promote growth and tumorigenicity of HCC cells, thus exerting an oncogenic role in hepatocarcinogenesis. Furthermore, survival analysis suggests that high OCT4-pg4 level is significantly correlated with poor prognosis of HCC patients. Taken together, our finding adds a new layer of post-transcriptional regulation of OCT4 and sheds new light on the treatment of human HCC. © The Author 2013. Published by Oxford University Press. All rights reserved.


Xin B.,No 88 Hospital Of Pla
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2012

To establish a hepatocellular carcinoma model of BALB/c mouse and to study the expression and potential role of metastasis-associated protein 1 (MTA1) in the carcinogenesis process. Normal adult male BALB/c mice were induced by the combined dimethylnitrosamine (DEN)/carbon tetrachloride (CCl(4);)/alcohol for 150 d. The morphological changes in liver cells and the expression of MTA1 in the liver lesions were observed by HE and immunohistochemical stainings, respectively. The pathological changes of the survivals' livers in experimental group were liver inflammation, fibrosis and cancer in sequence. The level of MTA1 increased in the carcinogenesis process, and MTA1 was mainly expressed in the cytoplasm of the cells suffering cirrhosis. The changes of the expression sites and quantity of MTA1 in the DEN-induced carcinogenesis of mouse liver indicate that MTA1 may play an important role in the whole process of liver carcinogenesis.


PubMed | No 88 Hospital Of Pla
Type: | Journal: Peptides | Year: 2014

Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin through an interaction with the orphan receptor GPR39. However, the effects of obestatin were not totally contrary to the effects of ghrelin in cardiovascular regulations based on the recent studies. We summarize here the current evidences surrounding the cardiovascular actions of obestatin, and the possible implications of obestatin as a therapeutic agent in common conditions such as hypertension and heart failure.

Loading No 88 Hospital Of Pla collaborators
Loading No 88 Hospital Of Pla collaborators