No 81 Hospital Of Pla

Nanjing, China

No 81 Hospital Of Pla

Nanjing, China

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Ji Y.-N.,Jiangsu Province Hospital of Traditional Chinese Medicine | Wang Q.,No 81 Hospital Of Pla | Suo L.-j.,Binzhou Medical University
PLoS ONE | Year: 2012

Many studies have examined the association between the CYP1A1 Ile462Val gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. Ultimately, 43 case-control studies, comprising 19,228 subjects were included. A significantly elevated lung cancer risk was associated with 2 Ile462Val genotype variants (for Val/Val vs Ile/Ile: OR = 1.22, 95% CI = 1.08-1.40; for (Ile/Val +Val/Val) vs Ile/Ile: OR = 1.15, 95% CI = 1.07-1.23) in overall population. In the stratified analysis, a significant association was found in Asians, Caucasians and lung SCC, not lung AC and lung SCLC. Additionally, a significant association was found in smoker population and not found in non-smoker populations. This meta-analysis suggests that the Ile462Val polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility in Asian and Caucasian populations and there is an interaction with smoking status, but these associations vary in different histological types of lung caner. © 2012 Ji et al.


Ji Y.-N.,Jiangsu Province Hospital of Traditional Chinese Medicine | Wang Q.,No 81 Hospital Of Pla | Lin X.-Q.,Guangzhou Medical College | Suo L.-J.,Binzhou Medical University
Cytokine | Year: 2012

Published data describing the association between CYP1A1 MspI gene polymorphism and lung cancer risk are inconclusive. To determine a more conclusive relationship, we performed an updated meta-analysis of all eligible studies and conducted the subgroup analysis by stratification according to the ethnicity source, histological types of lung cancer, gender and smoking status of case and control populations. A total of 51 studies comprising 20,209 subjects were included in the analysis. A significantly elevated lung cancer risk was associated with two variant genotypes (for TT vs CC: OR = 1.24, 95% CI = 1.11-1.40; for CT and TT combined vs CC: OR = 1.19, 95% CI = 1.12-1.27) in the overall population. In the stratified analysis, significantly higher risks associated with lung cancer were found in Asians, Caucasians, lung SCC, lung AC and the male population. In contrast, negligible risks were found in the mixed population, lung SCLC and the female population. Additionally, a significant association was found in the smoker population, whereas no association was found in non-smoker populations. This meta-analysis suggests that the MspI polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility, and that there is an interaction between the CYP1A1 polymorphism and smoking. However, the associations vary in different ethnic populations, histological types of lung cancer and the gender of case and control populations. © 2012 Elsevier Ltd.


Zhan P.,Nanjing Chest Hospital | Wang Q.,No 81 Hospital Of Pla | Qian Q.,Nanjing Chest Hospital | Wei S.-Z.,Nanjing University | Yu L.-K.,Nanjing Chest Hospital
Journal of Experimental and Clinical Cancer Research | Year: 2011

Background: Many studies have examined the association between the CYP1A1 MspI and exon 7 gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. Methods. To assess this relationship more precisely, a meta-analysis and review were performed. The PubMed, Embase, Web of Science, and CNKI database was searched for case-control studies published up to June 2010. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Ultimately, 64 studies, comprising 18,397 subjects from 49 case-control studies of the MspI genotype and 18,518 patients from 40 case-control studies of the exon 7 genotype, were included. A significantly elevated lung cancer risk was associated with 2 MspI genotype variants (for type C vs Type A: OR = 1.26, 95% CI = 1.12-1.42; for types B and C combined vs Type A: OR = 1.20, 95% CI = 1.13-1.28) in overall population. In the stratified analysis, a significant association was found in Asians, Caucasians, lung SCC, lung AC and Male population, not in mixed population, lung SCLC and Female population. However, inconsistent results were observed for CYP1A1 exon7 in our meta-analysis, two variants of the exon 7 polymorphism were associated with a significantly higher risk for lung cancer (for Val/Val vs Ile/Ile: OR = 1.24, 95% CI = 1.09-1.42; for (Ile/Val +Val/Val) vs Ile/Ile: OR = 1.15, 95% CI = 1.07-1.24) in overall population. In the stratified analysis, a significant assocation was found in Asians, Caucasians, lung SCC and Female population, not in mixed population, lung AD, lung SCLC and Male population. Additionally, a significant association was found in smoker population and not found in non-smoker populations for CYP1A1 MspI and exon7 gene. Conclusions: This meta-analysis suggests that the MspI and exon 7 polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility and there is an interaction between two genotypes of CYP1A1 polymorphism and smoking, but these associations vary in different ethnic populations, histological types of lung caner and gender of case and control population. © 2011 Zhan et al; licensee BioMed Central Ltd.


Zhan P.,Nanjing Chest Hospital | Wang Q.,No 81 Hospital Of Pla | Wei S.-Z.,Nanjing University | Wang J.,Nanjing University | And 3 more authors.
Journal of Thoracic Oncology | Year: 2010

Introduction: Published data on the association between XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk are inconclusive. Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed. Results: A total of 22 studies including 15,507 subjects for XPD Lys751Gln genotype and 13,198 subjects for XPD Asp312Asn genotype were examined. For XPD Lys751Gln genotype, significantly increased lung cancer risk was associated with two variant genotypes (CC versus AA: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.12-1.42, p = 0.473 for heterogeneity; C allele carriers versus AA: OR = 1.18, 95% CI = 1.08-1.36, p = 0.732 for heterogeneity). When stratified by ethnicity, significantly increased risks were found among Caucasians but not in Asians. For XPD Asp312Asn genotype, significantly increased lung cancer risk was associated with two variant genotypes (AA versus GG: OR = 1.24, 95% CI = 1.09-1.42, p = 0.104 for heterogeneity; the A allele carriers versus GG: OR = 1.35, 95% CI = 1.13-1.57, p = 0.219 for heterogeneity). When stratified analysis by ethnicity, significantly increased risks were found among Asians but not in Caucasians. In the subgroup analyses by smoking status, there were no significant associations among the nonsmoker subgroup; however, significantly increased lung cancer risks were found in the smoking group. CONCLUSION: This meta-analysis suggests that the XPD Lys751Gln and Asp312Asn gene polymorphisms are associated with lung cancer risk, the C allele of XPD Lys751Gln genotype is an increased risk factor for developing lung cancer among Caucasians and in smokers, and the A allele of XPD 312 genotype is also an increased risk factor among Asians and in smokers. © 2010 by the International Association for the Study of Lung Cancer.


Ji Y.-N.,Jiangsu Province Hospital of Traditional Chinese Medicine | Wang Q.,No 81 Hospital Of Pla | Zhan P.,Nanjing Chest Hospital
Molecular Biology Reports | Year: 2012

Coronary atherosclerosis is a leading cause of coronary heart disease (CHD). Atherosclerotic lesion is a complex polygenic disease in which gene-environment interactions play a critical role in disease onset and progression. The ICAM1 gene-E469K polymorphism has been reported to be associated with CHD, but results were conflicting. A systematic review and meta-analysis of the published studies were performed to gain a clearer understanding of this association. The PubMed, Embase, and CNKI databases were searched for case-control studies published up to August 2011. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Twelve eligible studies, comprising 2,157 cases and 1,952 controls, were included in the meta-analysis. The pooled result showed that the ICAM1 gene- E469K polymorphism was significantly associated with an increased risk of CHD (OR = 1.496, 95% CI = 1.363- 1.642, for the allele K vs. allele E; OR = 1.919, 95% CI = 11.635-2.253, for the K allele carriers vs. EE). Subgroup analysis supported the results in the Asian populations and in the Caucasian populations. This meta-analysis suggests that the ICAM1 gene K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD among Asian and Caucasians populations. © Springer Science+Business Media B.V. 2011.


Qiu C.-J.,No 81 Hospital Of Pla | Ye X.-Z.,Nanjing University | Yu X.-J.,No 81 Hospital Of Pla | Peng X.-R.,No 81 Hospital Of Pla | Li T.-H.,No 81 Hospital Of Pla
Journal of Cellular and Molecular Medicine | Year: 2014

Many studies have examined the association between the FABP2 (rs1799883) Ala54Thr gene polymorphism and type 2 diabetes mellitus risk (T2DM) in various populations, but their results have been inconsistent. To assess this relationship more precisely, A HuGE review and meta-analysis were performed. The PubMed and CNKI database was searched for case-control studies published up to April 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 13 studies, comprising 2020 T2DM cases and 2910 controls were included. Overall, for the Thr carriers (Ala/Thr and Thr/Thr) versus the wild-type homozygotes (Ala/Ala), the pooled OR was 1.18 (95% CI = 1.04-1.34, P = 0.062 for heterogeneity), for Thr/Thr versus Ala/Ala the pooled OR was 1.17 (95% CI = 1.05-1.41 P = 0.087 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were found among Asians but not Caucasians. This meta-analysis suggests that the FABP2 (rs1799883) Ala54Thr polymorphisms are associated with increased susceptibility to T2DM risk among Asians but not Caucasians. © 2014 The Authors.


Wang Q.,Nanjing Medical University | Wu X.,Nanjing University | Wu T.,Nanjing University | Li G.-M.,No 81 Hospital Of Pla | Shi Y.,Nanjing Medical University
Tumor Biology | Year: 2014

Raf-1 kinase inhibitor protein (RKIP) expression was associated with the onset, development, invasion, and metastasis of numerous tumor types including prostate cancer, melanoma, colorectal cancer, liver cancer, and breast cancer. However, RKIP mRNA expression and the clinical significance in non-small cell lung cancers (NSCLC) remain unresolved. Real-time PCR was performed to detect the expression of RKIP mRNA in 126 pairs of lung tumor tissues (TT) and surrounding normal tissues (sNT). Correlations between RKIP mRNA expression and clinicopathological features were evaluated by statistical analysis. In the 126 patients examined, RKIP mRNA expression was significantly lower in lung TT than the sNT (p<0.05). Our results indicated that downregulation of RKIP mRNA expression was associated with a poorer N-stage (p=0.019) and poorer pathological TNM stage (p=0.015). However, no significant association was observed between the expression status of RKIP mRNA and clinicopathologic factors, such as gender, age, histological type, and the size of the tumor (p>0.05). The level of RKIP mRNA expression was found to be significantly downregulated in NSCLC, and the lower mRNA levels correlated with poorer differentiation, advanced pathologic TNM stage in patients with NSCLC. © International Society of Oncology and BioMarkers (ISOBM) 2014.


PubMed | Nanjing University and No 81 Hospital Of Pla
Type: Review | Journal: The clinical respiratory journal | Year: 2016

The association of noncavitary untreated lung cancer with coexisting pulmonary Aspergillosis in immunocompetent patients is an extremely rare occurrence. The present paper aims to summarize the clinical data, and gives an overview of the current knowledge on the etiology, diagnosis and treatment of this condition.We report four cases and review seven cases in the literature.The four cases describe pulmonary solid tumor with coexisting pulmonary Aspergillosis condition. All cases underwent complicated procession for the terminal diagnosis.Clinicians should be alert to underlying malignant disease if airway Aspergillus infection is suspicious in a patient without strong risk factors for invasive fungal disease. On the other hand, when lung cancer is coexisting with airway necrotizing Aspergillosis, clinicians should properly manage these two diseases simultaneously.


Peng X.-R.,No 81 Hospital Of Pla
Chinese Critical Care Medicine | Year: 2011

Objective: To determine the impact of elevated in-hospital glucose level on outcome of patients with acute myocardial infarction (AMI), and evaluate the role of diabetes mellitus as a risk factor of AMI. Methods: The study included a retrospective analysis of AMI patients who were admitted to No. 81 Hospital of PLA from January 2000 to May 2010. In patients without a history of diabetes, and those with fasting blood glucose (FBG) ≥ 7.0 mmol/L at admission but returned to normal range soon after admission were defined as stress hyperglycemia of non-diabetic AMI patients. Both diabetic patients and non-diabetic patients were stratified into four mutually exclusive groups according to FBG levels: <7. 0, 7.0-7.9, 8.0-11.0 and ≥ 11.1 mmol/L. The in-hospital mortality, incidence of complications, and treatment to lower glucose level were analyzed. Logistic regression analysis was conducted on risk factors of outcome of AMI patients. Results: One hundred and fifty-two AMI patients were enrolled with 45 diabetic patients and 107 patients without previous diabetes. In diabetic group patients with FBG≥8. 0 mmol/L and those with FBG≥11. 1 mmol/L accounted for 73. 3% (33 cases) and 46. 7% (21 cases), respectively. In non-diabetic group patients with stress hyperglycemia accounted for 43. 9% (47 cases), among which patients with FBG levels of 7. 0 - 11. 0 mmol/L accounted for 91. 5% (43 cases). Compared with the non-diabetic group, the in-hospital mortality was significantly higher in diabetic group (35.6% vs. 15.9%, P = 0. 007). In both groups, the in-hospital mortality presented an elevating tendency with an increasing FBG level. Multivariate Logistic regression analysis demonstrated that in diabetic group patients with FBG ≥ 8. 0 mmol/L had 12. 28-fold higher risk of death than patients with FBG<8. 0 mmol/L, and that in non-diabetic group patients with FBG≥7. 0 mmol/L had 4. 81-fold higher risk of death than patients with FBG<7. 0 mmol/L. FBG was an independent risk factor of death with relative odds ratio {OR) 1. 03, with 95% confidence interval (95% CI) 1.01 -1. 16, P = 0. 012, and OR 1.56, 95%CI. 1.09-2.23, P = 0. 015 in diabetic group and non-diabetic group, respectively. The incidence of congestive heart failure in diabetic group was significantly higher than that in non-diabetic group (40.0% vs. 22.4%, P = 0. 027). In non-diabetic group, the incidence of lung infection, congestive heart failure, serious arrhythmias and acute cerebrovascular events (51.1%, 34.0%, 27.7%, 14.9%, respectively) was increased significantly in patients with FBG≥7. 0 mmol/L than that in patients with FBG<7. 0 mmol/L (18.3%, 13.3%, 10.0%, 0, respectively, P<0. 05 or P<0. 01). This association was not seen in diabetic group. 80.0% of patients (36 cases) in diabetic group received anti-hyperglycemia treatments in which insulin therapy accounted for 63. 9% (23 cases), while there was not even 1 patient who needed insulin therapy in non-diabetic patients with stress hyperglycemia. Conclusion: In-hospital mortality and complications were significantly increased in diabetic AMI patients and in non-diabetic AMI patients with stress hyperglycemia. Both a history of diabetes mellitus and stress hyperglycemia have strong influence on AMI prognosis. It seems to be more plausible to collaborate blood glucose level with history of diabetes in considering risk factors in AMI patients.


Wang Y.,No 81 Hospital Of Pla | Hua H.-Q.,No 81 Hospital Of Pla
Chinese Journal of Cancer Prevention and Treatment | Year: 2014

OBJECTIVE: To explore the research focus on palliative care of neoplasms from 2003 to 2013 by retrieving and cluster analyzing the literatures of large-scale database.METHODS: The literatures of palliative care of neoplasms indexed in the PubMed database from June 1, 2003 to June 1, 2013 were analyzed using bibliometric methods. The multidimensional clustering analysis and visualization of the literatures were conducted with bibliographic item co-occurrence matrix builder (BICOMB) software and social network analysis and visualization tool (UCINET) software.RESULTS: In PubMed database, there were 1 727 and 1 763 papers published from June 1, 2003 to June 1, 2008 and from June 2, 2008 to June 1, 2013 with 1064 and 1 192 subject words, respectively. Frequency of occurrence of the top 5 were palliative care (1 726), neoplasms (666), pain (161), lung neoplasms (137) and terminal care (129) from June 1, 2003 to June 1, 2008, and were palliative care (1 763), neoplasms (747), lung neoplasms (164), stents (152) and terminal care (128) from June 2, 2008 to June 1, 2013. Multidimensional clustering analysis showed that the literature subject of palliative care for neoplasms field included 23 research categories, involving a variety of solid tumor types. Compared with the previous five years, there were many new studies (education, clearness and speed, span, etc.) from June 2, 2008 to June 1, 2013. The quantitative visual analysis indicated that the main structures of the research focus (cancer, pain, anti-cancer drugs, end-stage treatment, the patient treatment team, etc.) on palliative care of neoplasms were formed from 2003 to 2013. From the co-author of view, there were only three groups and four groups co-authors with a higher frequency of published literatures.CONCLUSION: There are little change on the literature subjects of palliative care with the research focus on pain, end-stage treatment, anti-cancer drugs, patient care team and other aspects in many solid tumors.

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