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Baoding, China

Jiao J.-Q.,No. 5 Hospital of Baoding | Li Y.,No. 5 Hospital of Baoding | Huang Z.,Baoding Childrens Hospital | Hu W.-G.,No. 5 Hospital of Baoding
Chinese Journal of Tissue Engineering Research | Year: 2015

Background: Recombinant human epidermal growth factor has been shown to promote granulation tissue formation and to accelerate the healing of burn wounds, but the antibacterial effect of recombinant human epidermal growth factor is limited. Objective: To investigate the effect of nano-silver dressing combined with recombinant human epidermal growth factor gel in treatment of burns and the influence on the scar. Methods: A total of 76 cases of shallow II and depth II degree were randomly enrolled and assigned to two groups. In the study group, recombinant human epidermal growth factor was coated on the surface of the wound, and then covered by nano-silver dressing. In the control group, recombinant human epidermal growth factor was coated on the surface of the wound, and covered by ordinary sterile gauze. The healing time, the positive rate of bacteria, scarring and adverse reactions were compared between the two groups. Results And Conclusion: The wound healing time and the rate of hypertrophic scars after healing were lower in the study group than in the control group (P < 0.01). The rate of flat scar was greater in the study group than in the control group after healing (P < 0.01). The bacterial positive rate was significantly lower in the study group than in the control group at 7, 14 and 21 days after treatment (P < 0.05). No significant difference in incidence of allergies and local burning sensation was detected between the two groups (P > 0.05). These data confirmed that recombinant human epidermal growth factor gel combined with nano-silver dressing in the treatment of burn has good efficacy and accelerates the wound healing, reduces scar formation, and improves aesthetics. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source

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