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Shanghai, China

Zhou W.,Xiamen University | Qian H.,NO. 411 Hospital PLA | Yan L.,NO. 411 Hospital PLA | Luo D.,NO. 455 Hospital PLA | And 2 more authors.
Materials Letters | Year: 2015

In this study, we exploited the complex microsphere with different ratios of PLA/PCL loaded with clodronate (CL) for osteoporosis treatment in drug delivery system. Due to preparation with a modified double emulsion technique, microspheres of PLA/PCL showed spheres with small holes on the surface and a spongy porous inner structure. Microspheres of PLA/PCL showed spheres with small holes on the surface and a spongy porous inner structure, due to preparation with a modified double emulsion technique. They all had high encapsulation efficiency (more than 80%) and continuous degradation and release of CL. We focused on the controlled release of CL from different PLA/PCL complex microspheres, and found the increased release of CL was directly affected by degradation of microsphere. The similar bigger hole morphology of degradable microspheres was observed by SEM, which indicated significant passageways induced the burst release of CL. It was found that fast degradation induced the burst release of CL in the early stage. And slow degradation could lead to slower release in the whole process. Therefore, the release of CL could be regulated by ratios of PLA/PCL and by their degradation situation. It helped us to find the best complex microspheres (P75) contain 25% of PLA and 75% of PCL for osteoporosis, which has a continuous release of CL in 20 days and an extremely slow release in the last 10 days. © 2015 Published by Elsevier B.V. Source

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