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Sun X.-G.,Tang County of Hebei Provincial Peoples Hospital | Gao H.-B.,No 401 Hospital Of China Nuclear Industry | Wang B.,Tang County of Hebei Provincial Peoples Hospital | Wang H.-T.,Tang County of Hebei Provincial Peoples Hospital | And 2 more authors.
Journal of Dalian Medical University | Year: 2014

Objective: To study the use of different recovery fluid in patients with uncontrolled hemorrhagic shock resuscitation fluid plasma TNF-α, the influence of IL-2, so as to provide basis for uncontrolled hemorrhagic shock were treated by liquid recovery way. Methods: Forty patients with uncontrolled hemorrhagic shock were selected between April 2010 to August 2010, they were randomly divided into observation group and control group, observation group using restrictive liquidrecovery, and control group using conventional liquid recovery before bleeding control, serum TNF-α, IL-2 levels of change and recovery liquid intake during recovery in two groups were observed. Results: The average recovery liquid of patients in observation group was (1 946 ± 349) mL input variables significantly lower than control group, (3 522 ± 540) mL, with statistical difference (P < 0.05). Two groups patients serum TNF-α level 60 min after the recovery are higher than before the recovery level, with statistical difference (P < 0.05), the observation group of patients with serum TNF-α level 60 min after recovery level were significantly lower than the control group, with statistical difference (P<0.05). The patient's level of serum IL-2 of two group were higher than normal amount of 60 min after the recovery and the level before recovery, with statistical difference (P < 0.05), the observation group of patients with serum level of IL-2 in the 60 min after recovery levels were significantly lower than the control group, with statistical difference (P < 0.05). Conclusion: limited fluid resuscitation can significantly reduce uncontrolled hemorrhagic shock in patients with blood loss, stable flow mechanics, guarantee the important organs such as heart, brain, kidney blood perfusion, reduce the excessive blood dilution and acidosis, reduce serum TNF-α and IL-2 levels, improve the prognosis.


Bian H.,PLA Fourth Military Medical University | Zheng J.-S.,Capital Medical University | Nan G.,PLA Fourth Military Medical University | Li R.,Capital Medical University | And 15 more authors.
Journal of the National Cancer Institute | Year: 2014

To assess the efficacy of combining radioimmunoconjugate [131I] metuximab with radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) treatment compared with RFA alone, a single-center randomized controlled trial was conducted on 127 patients with Barcelona Clinic Liver Cancer staging system (BCLC) classifications of 0-B stage. Patients received either RFA followed by [131I] metuximab (n = 62) or RFA alone (n = 65). The primary outcome was overall tumor recurrence. Statistical tests were two-sided. The one- and two-year recurrence rates in the combination group were 31.8% and 58.5%, whereas those in the RFA group were 56.3% and 70.9%, respectively. The median time to overall tumor recurrence was 17 months in the combination group and 10 months in the RFA group (P =.03). The RFA-[131I] metuximab treatment showed a greater antirecurrence benefit than RFA in the metuximab target (ie, CD147)-positive subpopulation (P =.007). [131I] metuximab may yield prevention of tumor recurrence after RFA. © The Author 2014. Published by Oxford University Press. All rights reserved.


Gao H.-B.,No 401 Hospital Of China Nuclear Industry | Gao H.-B.,Shihezi University | Li N.,Shihezi University | Di Y.-Q.,No 401 Hospital Of China Nuclear Industry | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2011

OBJECTIVE: To investigate the expression of serum tissue polypeptide-specific antigen (TPS) in breast cancer patients and its clinical and pathological characteristics in such cases. METHODS: The serum TPS levels were detected by enzyme linked immunosorbent assay in 53 cases of breast cancer, 50 cases of benign breast diseases and 50 cases in normal control group. RESULTS: The levels and positivity rate of serum TPS in breast cancer group were significantly higher than those in the normal subjects group and benign lesion group 0= - 9. 275, P = 0.001; t = - 11. 25, P = 0.001). The levels of TPS in serum were significantly increased with TNM staging and TPS with clinical stage. In 53 primarily breast cancer patients, the concentration of TPS was not statistically different regarding the diameter of the mass (2 cm). The concentration of TPS was statistically significantly different between the positive and negative of ER/PR patients ( t = 3 . 0 72 , P = 0.003; t = 2.75 , P = 0.006), as well as c-erbB-2 (t= - 3. 981, P = 0.001). Serum concentration of TPS significantly correlates with ER, PR, c-erbB-2 and Ki-67 ( r = -0. 512, P = 0.001 ; r = -0.624 , P = 0.001 ; r = 0.441, P = 0.001 ; r = 0.514, P = 0.001). For TPS in regarding of the axillary lymph nodes metastasis, there were also significantly differences whether the number of metastatic lymph nodes. CONCLUSIONS:The high serum expression of TPS in breast cancer can be used as tumor marker for diagnosis of breast cancer. Serum concentration of TPS significantly correlates with axillary metastasis, ER, PR, c-erbB-2 and Ki-67, indicating that TPS is probably useful in evaluation and prognosis prediction of breast cancer.


Liu J.-T.,No 401 Hospital Of China Nuclear Industry | Pang H.,No 401 Hospital Of China Nuclear Industry | Gao H.-B.,No 401 Hospital Of China Nuclear Industry | Zhang S.-G.,No 401 Hospital Of China Nuclear Industry | Wang G.-F.,No 401 Hospital Of China Nuclear Industry
Journal of Dalian Medical University | Year: 2013

Objective: Intestinal fistula occurred after treatment in patients with colon cancer, diabetes mellitus treatment. Methods: Of 6 patients were placed on modified dripping fistula location lumen suction tube, continuous irrigation, to ensure adequate drainage, strict control of glucose, adequate nutritional support and other symptomatic treatment. Results: In 6 patients with conservative treatment recovered 3 months after treatment, 1 case of incision hernia, 1 case drainage tube mouth repeatedly infection, symptomatic treatment after recovery, 2 cases with recurrent intestinal obstruction after discharge, to court repeatedly healing after treatment. Conclusion: Colon cancer postoperative intestinal fistula patients with diabetes mellitus, after fine conservative treatment can obtain good curative effect.

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