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Changsha, China

Liu Y.,No. 163 Hospital of PLA
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2010

To investigate the effect of hyperbaric oxygen therapy to different degrees of hearing loss and different types of threshold curve in sudden deafness patients, and establish a personalized therapy, so as to promote clinical effect to sudden deafness. One hundred and twenty cases were divided into two groups respectively (each group 60 cases). Drug treatment had been used in group A for two weeks. The patients in group B received drug treatment combined with hyperbaric oxygen therapy for two weeks. According to the different degrees of hearing loss and the types of audiogram in two groups, the statistical analysis to the difference of hyperbaric oxygen therapeutic effect was done. The effective rates was statistically different (chi2 = 8.044, P < 0.01) between group A (60.00%, 36/60) and group B (83.33%, 50/60). There was no statistical difference between two treatment program in mild and the profound deafness patients. The statistical difference could been found between moderate and the severe deafness, the value of chi2 and p were 4.969, 5.560 and 0.040, 0.035, respectively. In group A, the statistical difference could only been found between mild and the profound deafness patients (chi2 = 6.739, P < 0.05). In group B, the statistical difference could been found in mild and the profound deafness, the moderate and the profound deafness, the severe and the profound deafness patients. The value of chi2 were 11.500, 15.058,10.221 and P < 0.01 respectively. The effective rates was no statistical difference in two treatment programs in the upsloping audiogram and the profound deafness. The statistical difference could been found between the downsloping and the flat audiogram, with the value of chi2 and p were 5.144 and 5.969, P < 0.05, respectively. In group A, the statistical difference could been found between the ascending and descending audiogram, the ascending and the flat audiogram,the ascending type and the profound deafness. The value of chi2 were 6.188, 7.247, 8.082 and P < 0.05, respectively. No statistical difference could been found among the other types of audiogram. In group B, no statistical difference could been found among all types of audiogram. The effect of hyperbaric oxygen therapy varies with degree of hearing loss and audiogram type. Drug treatment combined with HBOT can promote clinical effect for patients in moderate deafness and severe deafness, the descending and flat type of audiogram. Source


Liu Y.,No. 163 Hospital of PLA
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

To explore the best evaluating time of curative effect on sudden deafness so that the curative effect on sudden deafness can been evaluated more exactly and literally. Pure tone audiometries in 112 cases of sudden deafness were performed on the pretreatment day and on the third, seventh, fourteenth post-treatment day, and in the first, second, third, fourth post-treatment month. All of acoustical data were analyzed. The total effective rates were statistical different between the third, seventh post-treatment day and the fourteenth post-treatment day, the first, second, third, fourth post-treatment month. There were no statistical difference between the fourteenth post-treatment day and the first post-treatment month. There were statistical difference between the fourteenth post-treatment day and the second, third, fourth post-treatment month. The total effective rates were no statistical difference between the first and the second, third, fourth post-treatment month but it was fluctuated in the first post-treatment month. The total effective rates were no statistical difference between the second and the third, fourth post-treatment month and it was changeless on the second post-treatment month. From the curve of recruitment of hearing in different time, the curve of the total effective rates ascend from the third post-treatment day, then get to plateau from the second post-treatment month. If the cure rates, the efficiency rates, the effective rates in different time were analyzed, respectively, the hearing improvement ascend in first two weeks then. Hearing improvement get to plateau from fourteenth post-treatment day. (1) The evaluated results of curative effect to sudden deafness correlated vary in different time point post-treatment. (2) Prognosis can be predicted approximately 2 weeks after treatment. Patients who recover acoustic sensibility within 2 weeks have more significant improvement than the patients who hearing improvement after 2 weeks treatment. (3) The results of curative effect are stable after 2 months. If the data of this time were adopted, it would be more objective and accurate to evaluate the curative effect on sudden deafness. Source


Jiang L.,Central South University | Jiang L.,Hunan Key Laboratory of Otolaryngology critical diseases | Chen H.,Central South University | Chen H.,Hunan Key Laboratory of Otolaryngology critical diseases | And 15 more authors.
Biochemical and Biophysical Research Communications | Year: 2011

Objective: We analyzed the clinical features and family-related gene mutations for the first two Chinese cases of type IV Waardenburg syndrome (WS4). Methods: Two families were analyzed in this study. The analysis included a medical history, clinical analysis, a hearing test and a physical examination. In addition, the EDNRB, EDN3 and SOX10 genes were sequenced in order to identify the pathogenic mutation responsible for the WS4 observed in these patients. Results: The two WS4 cases presented with high phenotypic variability. Two novel heterozygous mutations (c.254G>A and c.698-2A>T) in the SOX10 gene were detected. The mutations identified in the patients were not found in unaffected family members or in 200 unrelated control subjects. Conclusions: This is the first report of WS4 in Chinese patients. In addition, two novel mutations in SOX10 gene have been identified. © 2011. Source


Zhang H.,Central South University | Zhang H.,Xinjiang Medical University | Chen H.,Central South University | Chen H.,Province Key Laboratory of Otolaryngology Critical Diseases | And 14 more authors.
Human Genetics | Year: 2012

Waardenburg syndrome (WS) is an auditory-pigmentary disorder resulting from melanocyte defects, with varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair, skin, and inner ear. WS is classified into four subtypes (WS1-WS4) based on additional symptoms. PAX3 and SOX10 are two transcription factors that can activate the expression of microphthalmia- associated transcription factor (MITF), a critical transcription factor for melanocyte development. Mutations of PAX3 are associated with WS1 and WS3, while mutations of SOX10 cause WS2 and WS4. Recently, we identified some novel WS-associated mutations in PAX3 and SOX10 in a cohort of Chinese WS patients. Here, we further identified an E248fsX30 SOX10 mutation in a family of WS2. We analyzed the subcellular distribution, expression and in vitro activity of two PAX3 mutations (p.H80D, p.H186fsX5) and four SOX10 mutations (p.E248fsX30, p.G37fsX58, p.G38fsX69 and p.R43X). Except H80D PAX3, which retained partial activity, the other mutants were unable to activate MITF promoter. The H80D PAX3 and E248fsX30 SOX10 were localized in the nucleus as wild type (WT) proteins, whereas the other mutant proteins were distributed in both cytoplasm and nucleus. Furthermore, E248fsX30 SOX10 protein retained the DNA-binding activity and showed dominant-negative effect on WT SOX10. However, E248fsX30 SOX10 protein seems to decay faster than the WT one, which may underlie the mild WS2 phenotype caused by this mutation. © Springer-Verlag 2011. Source


Wang X.-C.,No. 163 Hospital of PLA | Liu C.-H.,No. 163 Hospital of PLA | Chen Y.-J.,No. 163 Hospital of PLA | Yang W.,No. 163 Hospital of PLA | And 3 more authors.
Experimental and Therapeutic Medicine | Year: 2013

The aim of the present study was to identify the association between pathological types of kidney and clinical manifestations in patients with hypertensive nephropathy. The blood pressure, fundus, urinalysis test results and renal function changes were analysed in patients who were treated for hypertensive nephropathy. Downward kidney puncture biopsy was performed using a 16G ejection needle with the aid of B ultrasound in 47 cases. The specimens were observed using light microscopy and immunofluorescence. The pathological changes observed in the patients exhibiting symptoms of hypertensive nephropathy varied. The majority of clinical manifestations were benign arteriolar nephrosclerosis, hyaline degeneration of the renal artery and the appearance of a thickened wall of a thickened renal artery wall. Severe cases showed malignant arteriolar nephrosclerosis characterised by fibrinoid necrosis of renal arterioles and intimal hyperplasia. In addition, in the severe cases, fibrinoid necrosis of the afferent arteriole and arcuate artery wall was observed, with severe interlobular artery and arcuate artery myointimal thickening. Renal biopsy in patients with hypertensive nephropathy is safe and feasible. The prognosis and treatment of pathological and clinical disease related to renal pathology is necessary. Source

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