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Zamogylnaya Ya.A.,Nnblokhin Russian Cancer Research Center Rams
Voprosy Onkologii | Year: 2012

263 tumors diagnosed as malignant fibrous histiocytomas and undifferentiated pleomorphic sarcomas have been reassessed morphologically, immunohistochemically and ultrastructurally. The diagnosis of pleomorphic fibrosarcoma was made in 19 patients (5%). The tumors occur in the lower and upper extremities and trunk. The patients have a long history of painless intramuscular mass (for a median of 6 months). Follow up showed disease recurrence in 24% of patients and metastases in 32% of patients. All tumors consisted of spindle-shaped fibroblasts and myofibroblasts with a prominent rough endoplasmic reticulum and Golgi apparatus, extracellular collagen fibrils. Variable number of histiocite-like fibroblasts and undifferentiated cells were found. No other signs of tumor cell line differentiation were noted. A pleomorphic fibrosarcoma and malignant fibrous histiocytoma have similar clinical and radiographic manifestation and survival rates. Source

Andreeva O.E.,Nnblokhin Russian Cancer Research Center Rams | Scherbakov A.M.,Nnblokhin Russian Cancer Research Center Rams | Shatskaya V.A.,Nnblokhin Russian Cancer Research Center Rams | Krasil'nikov M.A.,Nnblokhin Russian Cancer Research Center Rams
Voprosy Onkologii | Year: 2012

The loss of hormonal dependency in breast tumor cells is often accompanied by epithelial-mesenchymal transition (EMT) features and an increase in cell metastasizing and invasiveness. Here we studied the role of transcription factors Snail 1 - the central mediator of EMT, in the progression of hormonal resistance of breast cancer cells. The experiments were performed on the estrogen receptor(ER)-positive estrogen-dependent MCF-7 breast cancer cells, ER-positive estrogen-resistant MCF-7/LS subline generated through long-term cultivation of the parental cells in steroid-free medium, and ER-negative estrogen-resistant HBL-100 breast cancer cells. We found that decrease in the estrogen dependency of breast cancer cells is accompanied by an increase in Snail1 expression and activity, and demonstrated the Snail1 involvement in the negative regulation of ER. NF-κB was found to serve as a positive regulator of Snail1 in breast cancer cells, and simultaneous inhibition of NF-κB and Snail1 by RNA interference resulted in marked increase of cell response to anti-estrogen tamoxifen. In general, the results obtained demonstrate that direct inhibition of NF-κB and Snail1 partially restores the estrogen receptor machinery, and show that Snail1 and NF-κB may serve as an important targets in the treatment of breast cancer. Source

Nered S.N.,Nnblokhin Russian Cancer Research Center Rams | Stilidi I.S.,Nnblokhin Russian Cancer Research Center Rams | Klimenkov A.A.,Nnblokhin Russian Cancer Research Center Rams | Bolotsky V.I.,Nnblokhin Russian Cancer Research Center Rams | Anurova O.A.,Nnblokhin Russian Cancer Research Center Rams
Voprosy Onkologii | Year: 2012

The separate clinico-morphological features of nonorganic retroperitoneal liposarcoma (NRL) and their prognostic value were studied in 200 patients. The type of primary NRL is histologically differentiated in 65,5%, myxoid in 16,1%, dedifferentiated in 9,2%, pleomorphic in 4,6% and mixed in 2,3%. There is a positive relation between overall survival, lyposarcoma hystologic type (p<0,007) and completeness of tumor resection (p<0,0008). Differentiated and myxoid NRL with cell volume less than 5,0% are characterized by better prognosis. Myxoid NRL with cell volume more than 5,0%, dedifferentiated and pleomorphic NRL types are unfavorable prognostic factors. Radical surgical resection leads to 5-year and 10-year overall survival of 57,5% and 37,8%. Palliative surgery lead to worse results with 3-year and 5-year overall survival of 50,0% and 31,8% respectively. Therefore, the most important prognostic factors in NRL are histological type and completeness of resection. Source

Kochojan T.M.,Nnblokhin Russian Cancer Research Center Rams | Berishvili A.I.,Nnblokhin Russian Cancer Research Center Rams | Sletina S.Y.,Nnblokhin Russian Cancer Research Center Rams | Komov D.M.,Nnblokhin Russian Cancer Research Center Rams | And 5 more authors.
Voprosy Onkologii | Year: 2012

Estrogens play the most important role in breast cancer oncogenesis. There are different methods used to decrease estrogen production and serum concentration: surgery, irradiation and drug-based method. In the current study 500 patients with localized surgically resectable breast cancer (infiltrative-edematous form included) or disseminated breast cancer with indication for ovarial function inhibition. The patients were divided into 3 groups. The first group consisted of 400 patients with prior endoscopic bilateral ovariectomy. The second group included 50 patients with prior ovarian irradiation, the third one included 50 patients after laparotomic ovarian resection. The results obtained show 100% effect of endoscopic ovariectomy resulted in disabled ovarian function, which is more effective, than ovarian irradiation (92%). Besides, the endoscopic method doesn't have negative effects characteristic for irradiation, such as involvement of non-target organs or restoration of hormone production. Endoscopic surgery was characterized by 10-fold decrease in complications rate compared to laparotomic operation (2,2% vs 24%). Besides, endoscopic intervention leads to much shorter inpatient treatment duration and demand for anesthetics and antibiotic treatment making it less costly, than more traditional methods of castration. Therefore, endoscopic ovarian resection is a safe and effective castration method in breast cancer patients. Source

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