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Allum W.H.,University College London | Bonavina L.,University of Milan | Cassivi S.D.,Mayo Medical School | Cuesta M.A.,VU University Amsterdam | And 24 more authors.
Annals of the New York Academy of Sciences | Year: 2014

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the role of the nurse in preparation of esophageal resection (ER); the management of patients who develop high-grade dysplasia after having undergone Nissen fundoplication; the trajectory of care for the patient with esophageal cancer; the influence of the site of tumor in the choice of treatment; the best location for esophagogastrostomy; management of chylous leak after esophagectomy; the optimal approach to manage thoracic esophageal leak after esophagectomy; the choice for operational approach in surgery of cardioesophageal crossing; the advantages of robot esophagectomy; the place of open esophagectomy; the advantages of esophagectomy compared to definitive chemoradiotherapy; the pathologist report in the resected specimen; the best way to manage patients with unsuspected positive microscopic margin after ER; enhanced recovery after surgery for ER: expedited care protocols; and long-term quality of life in patients following esophagectomy. © 2014 New York Academy of Sciences. Source


Patyutko Yu.I.,Nnblokhin Russian Cancer Research Center | Kotelnikov A.G.,Nnblokhin Russian Cancer Research Center | Mamontov K.G.,Altai Branch Of The Nnblokhin Russian Cancer Research Center | Podluzhny D.V.,Nnblokhin Russian Cancer Research Center
Voprosy Onkologii | Year: 2015

The current study aimed at improvement of treatment effects for patients with resectable metastases of colorectal cancer in the liver with a poor prognosis. Overall 437 patients were enrolled with metastatic colorectal cancer in the liver exhibiting at least one adverse factor of long-term prognosis: multiple metastases, bilobar liver metastases, large metastases, the presence of extrahepatic metastases, etc. Combined treatment was performed for 339 (78%) patients: combined treatment with adjuvant systemic chemotherapy (163 patients), combined treatment with perioperative systemic chemotherapy (54 patients), or combined treatment of perioperative regional chemotherapy (122 patients). Surgical treatment was performed in 66 (15%) patients. The remaining group of 32 (7%) patients with resectable metastases who received only systemic chemotherapy was considered separately. All liver resections were extensive due to the widespread metastases. The complication rate stood at 56%. Lethality among operated patients was 4%. Postoperative lethality and complications as well as the intraoperative blood loss were not statistically different in two groups. Adding bevacizumab to preoperative chemotherapy did not increase blood loss. After combined treatment with adjuvant chemotherapy a 5-year survival was 26±4% that significantly outperforming a 5-year survival rate after surgery (17±5%), after just drug treatment a 5-year survival has not been reached, and also after combined treatment with perioperative systemic chemotherapy (13±5%) and not statistically significant exceeded a 5-year survival after combined treatment with perioperative regional chemotherapy (20±5%). Thus our study demonstrates the benefits of combined treatment with adjuvant systemic chemotherapy for resectable metastases of colorectal cancer in the liver with a poor prognosis For initially unresectable metastases with extrahepatic manifestations of the disease treatment should be begun with systemic chemotherapy. To liver resection in the latter cases there are resorted only after the transfer of patients in operable condition. Source


Nechnshkina V.M.,Russian National Research Medical University | Morkhov K.Yu.,Nnblokhin Russian Cancer Research Center | Kuznetsov V.V.,Nnblokhin Russian Cancer Research Center | Egorova A.V.,Russian National Research Medical University
Voprosy Onkologii | Year: 2015

The article is devoted to one of the most controversial issues of modern oncogynecology - the volume of surgery for endometrial cancer of early stages. There are discussed the indications for lymphadenectomy and its volume as well as how correlate performing lymphadenectomy and conducting postoperative radiotherapy. Source


Rybalkina E.Yu.,Nnblokhin Russian Cancer Research Center | Stromskaya T.P.,Nnblokhin Russian Cancer Research Center | Ovchinnikov L.P.,Research Institute of Protein | Stavrovskaya A.A.,Nnblokhin Russian Cancer Research Center
Voprosy Onkologii | Year: 2013

In this study, we investigated how the protein YB-1 influenced on the expression of genes coding ABC transporters and on drug resistance in several cell lines, in which originally gene MDR1, coding P-glycoprotein, was not expressed. These populations were significantly different in the presence of mRNA YB-1 and the nature of the intracellular localization of the protein YB-1. However incubation of cells in all studied populations in the culture medium with serum after starvation led to translocation of YB-1 in the cell nucleus. The increase of the number of cells with nuclear localization of YB-1 correlated with increased amount of mRNA YB-1. Processing of cells with drug LY-294,002 by PI3K/Akt inhibitor prevented the translocation of the protein YB-1 into the nuclei of cells, and the cells became more sensitive to the toxic action. Thus, we observed that the signaling pathways involved in control of cell proliferation, in particular a signaling cascade PI3K/Akt were involved in the control of the intracellular localization of YB-1 in cell populations of ovarian cancer, melanoma and human prostate cancer. In these cells the nuclear localization of YB-1 correlated with an expression of MDR and MRP1 DCRP genes and with a sensitivity of cells to a number of drugs. Source


Allakhverdiev A.K.,Nnblokhin Russian Cancer Research Center | Davidov M.M.,Nnblokhin Russian Cancer Research Center | Davidov M.I.,Nnblokhin Russian Cancer Research Center
Voprosy Onkologii | Year: 2015

In recent years a large number of thoracic clinics in the world recommend the performance of minimally invasive surgical procedures in the early stages of lung cancer arguing that this technique reduces a number of postoperative complications, shortens the period of social rehabilitation of patients and does not significantly affect the long-term results of treatment. This work is devoted to the study of immediate and long-term results of surgical treatment of patients who have had surgery in the volume of thoracoscopic lobectomy at the early stages of non-small cell lung cancer. Source

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