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Harders S.W.,Aarhus University Hospital | Balyasnikowa S.,Nn Blokhin Russian Cancer Research Center Rams | Fischer B.M.,Nuclear Medicine and PET
Clinical Physiology and Functional Imaging | Year: 2014

Lung cancer represents an increasingly frequent cancer diagnosis worldwide. An increasing awareness on smoking cessation as an important mean to reduce lung cancer incidence and mortality, an increasing number of therapy options and a steady focus on early diagnosis and adequate staging have resulted in a modestly improved survival. For early diagnosis and precise staging, imaging, especially positron emission tomography combined with CT (PET/CT), plays an important role. Other functional imaging modalities such as dynamic contrast-enhanced CT (DCE-CT) and diffusion-weighted MR imaging (DW-MRI) have demonstrated promising results within this field. The purpose of this review is to provide the reader with a brief and balanced introduction to these three functional imaging modalities and their current or potential application in the care of patients with lung cancer. © 2013 The Authors. Source

Knappskog S.,University of Bergen | Gansmo L.B.,University of Bergen | Dibirova K.,Russian Academy of Medical Sciences | Metspalu A.,University of Tartu | And 34 more authors.
Oncotarget | Year: 2014

The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of SNP285C was 6-8% across European populations except for Finns (1.2%) and Saami (0.3%). The incidence decreased towards the Middle-East and Eastern Russia, and SNP285C was absent among Han Chinese, Mongolians and African Americans. Interhaplotype variation analyses estimated SNP285C to have originated about 14,700 years ago (95% CI: 8,300 - 33,300). Both this estimate and the geographical distribution suggest SNP285C to have arisen after the separation between Caucasians and modern day East Asians (17,000 - 40,000 years ago). We observed a strong inverse correlation (r = -0.805; p < 0.001) between the percentage of SNP309G alleles harboring SNP285C and the MAF for SNP309G itself across different populations suggesting selection and environmental adaptation with respect to MDM2 expression in recent human evolution. In conclusion, we found SNP285C to be a pan-Caucasian variant. Ethnic variation regarding distribution of SNP285C needs to be taken into account when assessing the impact of MDM2 SNPs on cancer risk. Source

Moizhess T.G.,Nn Blokhin Russian Cancer Research Center Rams | Vasiliev Ju.M.,Nn Blokhin Russian Cancer Research Center Rams
Tsitologiya | Year: 2013

This study is dedicated to the problem of the origin of progenitor cells of sarcomas induced by implantation of a foreign body (polyvinilchloride plates) to mice. It is known that such cells are found among the cells of the monolayer covering the surface of implanted plate without any signs of tumor growth in 6 and more months after implantation. We studied the existence of endothelial features of mesenchymal type cells that had been grown by culturing the cells from the implanted plate surface in 9 and 14 months after implantation. We have shown that these cells are really the precursors of FB sarcomas thou they had different tumor potential depending on the period since implantation moment. We studied the behavior of these pretumor cells in 2D (on plastic) and 3D (on matrigel) cultures. We have found that in the case of a dense monolayer on plastic such cells show growth of endothelial type (cobblestone). When sown on matrigel they are organized in more or less typical capillary-like structures that subsequently form secondary branching vascular-like structures named «secondary sprouting». Such behavior is also characteristic for endothelial cells. This observations allow us to postulate the possibility of endothelial origin of FB sarcomas. Source

Diduk S.V.,Nn Blokhin Russian Cancer Research Center Rams | Smirnova K.V.,Nn Blokhin Russian Cancer Research Center Rams | Gurtsevitch V.E.,Nn Blokhin Russian Cancer Research Center Rams
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2012

One of the latent proteins encoded by the Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1), plays a key role in developing of EBV-associated human malignancies. Polymorphism of LMP1 protein is its characteristic feature. Some specific mutations in LMP1 genome have previously been detected in different geographic regions, however, the influence of these mutations on functional activity of LMP1 was not still determined. In this study we demonstrated for the first time the significance of individual point mutations among common ones observed in LMP1 and their combination on activation of the inducible form of nitric oxide synthase (iNOS). in addition, the influence of above mutations localized in the CTAR regions of the LMP1 molecule has also been investigated on structural components of the fibroblasts of the Ratlcell line. Source

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